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Molecules 2018, 23(5), 1060; https://doi.org/10.3390/molecules23051060

Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple

1
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process/Laboratory of Agro-products Quality Safety Risk Assessment, Ministry of Agriculture, Beijing 100193, China
2
Functional and Evolutionary Entomology, Gembloux Agro-Bio-Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium
3
Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University (BTBU), Beijing 100048, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Jacek Namieśnik and Justyna Płotka-Wasylka
Received: 3 April 2018 / Revised: 20 April 2018 / Accepted: 29 April 2018 / Published: 2 May 2018
(This article belongs to the Special Issue Recent Advances in Studies of Food and Beverages)
Full-Text   |   PDF [2448 KB, uploaded 3 May 2018]   |  

Abstract

Ultra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-performance convergence chromatography coupled with tandem mass spectrometry, which shows that stereoisomer recoveries determined for various apple parts ranged from 78.3% to 119.9%, with the relative standard deviations being lower than 14.0%. The half-lives of (−)-cyflumetofen and (+)-cyflumetofen obtained under 5-fold applied dosage equal to 22.13 and 22.23 days, respectively. For 1.5-fold applied dosage, the respective values were determined as 22.42 and 23.64 days, i.e., the degradation of (−)-cyflumetofen was insignificantly favored over that of its enantiomer. Importantly, cyflumetofen was unevenly distributed in apples, with its relative contents in apple peel, peduncle, and pomace equal to 50%, 22%, and 16%, respectively. The proposed method can be used to efficiently separate and quantify chiral pesticide with advantages of a shorter analysis time, greater sensitivity, and better environmental compatibility. Additionally, the consumption of apples with residue of cyflumetofen did not pose a health risk to the population if the cyflumetofen applied under satisfactory agricultural practices after the long-term dietary risk assessment. View Full-Text
Keywords: chiral cyflumetofen; enantioselective degradation; distribution; ultra-performance convergence chromatography; dietary risk assessment chiral cyflumetofen; enantioselective degradation; distribution; ultra-performance convergence chromatography; dietary risk assessment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Guo, J.; Li, M.; Liu, Y.; Wang, F.; Kong, Z.; Sun, Y.; Lu, J.; Jin, N.; Huang, Y.; Liu, J.; Francis, F.; Fan, B. Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple. Molecules 2018, 23, 1060.

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