Molecules 2018, 23(3), 672; https://doi.org/10.3390/molecules23030672
Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2
Carolina De la Guardia 1,2
, David E. Stephens 3, Hang T. Dang 3, Mario Quijada 1, Oleg V. Larionov 3 and Ricardo Lleonart 1,*
, David E. Stephens 3, Hang T. Dang 3, Mario Quijada 1, Oleg V. Larionov 3 and Ricardo Lleonart 1,*
1
Institute of Scientific Research and High Technology Services (INDICASAT AIP), PO 0843-01103 City of Panama, Panama
2
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, Andhra Pradesh, India
3
Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA
*
Author to whom correspondence should be addressed.
Received: 19 February 2018 / Revised: 13 March 2018 / Accepted: 15 March 2018 / Published: 16 March 2018
(This article belongs to the Section Chemical Biology)
Abstract
Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis and antiviral activity evaluation of two compounds based on the quinoline scaffold, which has shown potential for the development of molecules with various biological activities. Two of the tested compounds showed dose-dependent inhibition of dengue virus serotype 2 in the low and sub micromolar range. The compounds 1 and 2 were also able to impair the accumulation of the viral envelope glycoprotein in infected cells, while showing no sign of direct virucidal activity and acting possibly through a mechanism involving the early stages of the infection. The results are congruent with previously reported data showing the potential of quinoline derivatives as a promising scaffold for the development of new antivirals against this important virus. View Full-TextKeywords:
dengue virus; quinolines; antiviral
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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De la Guardia, C.; Stephens, D.E.; Dang, H.T.; Quijada, M.; Larionov, O.V.; Lleonart, R. Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2. Molecules 2018, 23, 672.
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