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Molecules 2018, 23(3), 639; https://doi.org/10.3390/molecules23030639

Prenylated Polyphenols from Broussonetia kazinoki as Inhibitors of Nitric Oxide Production

1,†
,
2,†
and
1,*
1
College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women’s University, Seoul 04310, Korea
2
School of Industrial Bio-Pharmaceutical Science, Semyung University, Jecheon, Chungbuk 27136, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 20 February 2018 / Revised: 7 March 2018 / Accepted: 9 March 2018 / Published: 12 March 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Excessive nitric oxide (NO) production by macrophages has been involved in inflammatory diseases. Seven polyphenols (17) were isolated from Broussonetia kazinoki (B. kazinoki) and investigated as potential inhibitors of NO overproduction in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Among them, four prenylated polyphenols (24 and 6) with a catechol moiety efficiently suppressed the LPS-induced high level of NO with IC50 values of less than 6 µM. The compounds 24 and 6 also attenuated protein and mRNA levels of inducible nitric oxide synthase (iNOS). Moreover, they suppressed the nuclear factor κB (NF-κB) activity by inhibiting the degradation of inhibitory-κB-α (I-κB-α) and the translocation of NF-κB into the nucleus in LPS-activated macrophages. Taken together, these findings suggest that polyphenols from B. kazinoki might be beneficial for treatment of inflammatory diseases. View Full-Text
Keywords: Broussonetia kazinoki; prenylated polyphenols; nitric oxide; inducible nitric oxide synthase; nuclear factor κB Broussonetia kazinoki; prenylated polyphenols; nitric oxide; inducible nitric oxide synthase; nuclear factor κB
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Lee, D.Y.; Lee, H.J.; Ryu, J.-H. Prenylated Polyphenols from Broussonetia kazinoki as Inhibitors of Nitric Oxide Production. Molecules 2018, 23, 639.

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