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Molecules 2018, 23(3), 638; https://doi.org/10.3390/molecules23030638

Recent Advances in Zirconium-89 Chelator Development

Department of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA
These authors contributed equally to this work.
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Received: 11 February 2018 / Revised: 8 March 2018 / Accepted: 9 March 2018 / Published: 12 March 2018
(This article belongs to the Special Issue Current Aspects of Radiopharmaceutical Chemistry)
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Abstract

The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it must be stably bound to a targeting ligand, and the most successfully used 89Zr chelator is desferrioxamine B (DFO), which is commercially available as the iron chelator Desferal®. Despite the prevalence of DFO in 89Zr-immuno-PET applications, the development of new ligands for this radiometal is an active area of research. This review focuses on recent advances in zirconium-89 chelation chemistry and will highlight the rapidly expanding ligand classes that are under investigation as DFO alternatives. View Full-Text
Keywords: zirconium-89; chelator; positron emission tomography zirconium-89; chelator; positron emission tomography
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Bhatt, N.B.; Pandya, D.N.; Wadas, T.J. Recent Advances in Zirconium-89 Chelator Development. Molecules 2018, 23, 638.

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