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Molecules 2018, 23(3), 614; https://doi.org/10.3390/molecules23030614

Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus

1
State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, China
2
Department of Pharmacology, State Province Key Laboratories of Biomedicine and Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, No. 157, Baojian Road, Nangang District, Harbin 150086, China
*
Authors to whom correspondence should be addressed.
Received: 14 February 2018 / Revised: 7 March 2018 / Accepted: 7 March 2018 / Published: 8 March 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is mediated by multiple signaling pathways. In recent years, the components of Psoralea Fructus (PF) have demonstrated some anti-Alzheimer effects both in vitro and in vivo. To further reveal the active compounds of PF and their mechanisms regulating key targets of AD, in this study, we identified four prenylated compounds from the 70% ethanolic aqueous extract of PF, namely bavachin, bavachinin, bavachalcone, and isobavachalcone. Multi-target bioactivity analysis showed that these compounds could differentially inhibit neuroinflammation, oxidative damage, and key AD-related protein targets, such as amyloid β-peptide 42, β-secretase, glycogen synthase kinase 3β, and acetylcholinesterase. These compounds may generate beneficial effects in AD prevention and treatment. View Full-Text
Keywords: Psoraleae Fructus; Alzheimer’s; bavachin; bavachinin; bavachalcone; isobavachalcone; oxidative damage; neuroinflammation; BV-2 microglia; amyloid β-peptide 42 Psoraleae Fructus; Alzheimer’s; bavachin; bavachinin; bavachalcone; isobavachalcone; oxidative damage; neuroinflammation; BV-2 microglia; amyloid β-peptide 42
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xu, Q.-X.; Hu, Y.; Li, G.-Y.; Xu, W.; Zhang, Y.-T.; Yang, X.-W. Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus. Molecules 2018, 23, 614.

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