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Molecules 2018, 23(3), 603; https://doi.org/10.3390/molecules23030603

One-Step Preparation of Phenyl Boron-Modified Magnetic Mesoporous Silica for Selective Enrichment of cis-Diol-Containing Substances

1
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
2
School of Chemical Engineering, Qinghai University, Xining 810016, China
3
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
*
Authors to whom correspondence should be addressed.
Received: 1 February 2018 / Revised: 2 March 2018 / Accepted: 2 March 2018 / Published: 7 March 2018
(This article belongs to the Section Analytical Chemistry)
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Abstract

For enrichment and separation of cis-diol-containing compounds from biomatrix, a new type of magnetic nanoparticles named MS-48-PBSC, whichwas facilely prepared in a one-step heterogeneous reaction. The morphology results demonstrated that the MS-48-PBSC was a spherical nanomaterial containing a core of silica-coated magnetic particle with a diameter of about 200 nm, and a cover layer of mesoporous silica with a thickness of approximate 50 nm. The characterization results showed that MS-48-PBSC presented a pore size of 4.2 nm, a surface area of 548 m2·g−1, and a pore volume of 0.30 cm3·g−1. The MS-48-PBSC also exhibited magnetism of 42 emu·g−1 that contributed to the easy separation of magnetic nanomaterial within 30 s from the matrix with the aid of the external magnetic field. In addition, the MS-48-PBSC exhibited high adsorption capacity for adenosine, xanthosine, uridine, sialic acid, and teicoplanin with 0.60, 0.51, 0.42, 0.75, and 1.26 mg/g, respectively, and showed a high selectivity for the cis-diol structure compounds, relative to interferences of bovine serum albumin, guanine, uric acid, and xanthine. The recoveries of adenosine, xanthosine, uridine, sialic acid, and teicoplanin were 71.8–114.1% with relative standard deviation (RSD) ≤ 8.6%, and the enrichment factors of them were 8–11. MS-48-PBSC exhibited quick separation capability from matrix, high adsorption capacity and size exclusion for bovine serum albumin, which could meet the requirements of separation and enrichment for substances with a cis-diol structure. View Full-Text
Keywords: magnetic solid-phase extraction; one-step preparation; phenylboronic acid; cis-diol-containing substance; selective enrichment magnetic solid-phase extraction; one-step preparation; phenylboronic acid; cis-diol-containing substance; selective enrichment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Fu, H.; Hu, J.; Zhang, M.; Wang, Y.; Zhang, H.; Hu, P. One-Step Preparation of Phenyl Boron-Modified Magnetic Mesoporous Silica for Selective Enrichment of cis-Diol-Containing Substances. Molecules 2018, 23, 603.

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