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Open AccessArticle

Synthesis, Antibacterial, and Anti HepG2 Cell Line Human Hepatocyte Carcinoma Activity of Some New Potentially Benzimidazole-5-(Aryldiazenyl)Thiazole Derivatives

1
Department of Chemistry, faculty of Science, Taif University, Taif 21974, Saudi Arabia
2
Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza 12613, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3285; https://doi.org/10.3390/molecules23123285
Received: 16 November 2018 / Revised: 6 December 2018 / Accepted: 9 December 2018 / Published: 11 December 2018
(This article belongs to the Collection Heterocyclic Compounds)
The paper describes the synthesis and biological evaluation of some new benzimidazole derivatives as potent clinical drugs that are useful in the treatment of some microbial infections and tumor inhibition. The starting compound 2-(bromomethyl)-1H-benzimidazole (1) was prepared, and hence underwent interesting functionalization reactions to afford several series of benzimidazole-5-(aryldiazenyl)thiazole derivatives: 3ac, 7ac, and 8ac. The antibacterial activities of the synthesized compounds were evaluated by calculation of the inhibition zone diameter (mm) and the determination of minimum inhibitory concentration (µg/mL) against selected pathogenic bacteria Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria).Noticeable efficiency was found based on in vitro screening for their antioxidant activity and cytotoxicity effect against the human liver cancer cell line (HepG2) and human hepatocyte carcinoma cells at relatively high concentrations. View Full-Text
Keywords: benzimidazoles; antimicrobial activity; antitumor; HepG2 cell line; pathogenic bacteria benzimidazoles; antimicrobial activity; antitumor; HepG2 cell line; pathogenic bacteria
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MDPI and ACS Style

Khalifa, M.E.; Gobouri, A.A.; Kabli, F.M.; Altalhi, T.A.; Almalki, A.S.A.; Mohamed, M.A. Synthesis, Antibacterial, and Anti HepG2 Cell Line Human Hepatocyte Carcinoma Activity of Some New Potentially Benzimidazole-5-(Aryldiazenyl)Thiazole Derivatives. Molecules 2018, 23, 3285.

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