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Molecules 2018, 23(12), 3157; https://doi.org/10.3390/molecules23123157

Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring

1
Institute of Photonics and Optoelectronics, and Department of Electrical Engineering, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan
2
Institute of Micro/Nano Photonic Materials and Application, School of Physics and Electronics, Henan University, Kaifeng 475004, China
3
Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi’an Jiaotong University, No.28, Xianning West Road, Xi’an 710049, Shanxi, China
*
Author to whom correspondence should be addressed.
Academic Editor: Joan Estelrich
Received: 30 October 2018 / Revised: 27 November 2018 / Accepted: 30 November 2018 / Published: 30 November 2018
(This article belongs to the Special Issue Photothermal Agents in Therapy)
Full-Text   |   PDF [9259 KB, uploaded 30 November 2018]   |  

Abstract

The methods of cell perforation and preheating are used for increasing cell uptake efficiencies of gold nanorings (NRIs), which have the localized surface plasmon resonance wavelength around 1064 nm, and photosensitizer, AlPcS, and hence enhancing the cell damage efficiency through the photothermal (PT) and photodynamic (PD) effects. The perforation and preheating effects are generated by illuminating a defocused 1064-nm femtosecond (fs) laser and a defocused 1064-nm continuous (cw) laser, respectively. Cell damage is produced by illuminating cell samples with a focused 1064-nm cw laser through the PT effect, a focused 1064-nm fs laser through both PT and PD effects, and a focused 660-nm cw laser through the PD effect. Under various conditions with and without cell wash before laser illumination, through either perforation or preheating process, cell uptake and hence cell damage efficiencies can be enhanced. Under our experimental conditions, perforation can be more effective at enhancing cell uptake and damage when compared with preheating. View Full-Text
Keywords: cell perforation; cell preheating; surface plasmon resonance; photothermal therapy; photodynamic therapy cell perforation; cell preheating; surface plasmon resonance; photothermal therapy; photodynamic therapy
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Hsiao, J.-H.; He, Y.; Yu, J.-H.; Tseng, P.-H.; Hua, W.-H.; Low, M.C.; Tsai, Y.-H.; Cai, C.-J.; Hsieh, C.-C.; Kiang, Y.-W.; Yang, C.-C.; Zhang, Z. Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring. Molecules 2018, 23, 3157.

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