Next Article in Journal
Effect of Photodynamic Antibacterial Chemotherapy Combined with Antibiotics on Gram-Positive and Gram-Negative Bacteria
Next Article in Special Issue
Chenodeoxycholic Acid from Bile Inhibits Influenza A Virus Replication via Blocking Nuclear Export of Viral Ribonucleoprotein Complexes
Previous Article in Journal
A Charge-Transfer Salt Based on Ferrocene/Ferrocenium Pairs and Keggin-Type Polyoxometalates
Previous Article in Special Issue
A Computational Approach for the Prediction of HIV Resistance Based on Amino Acid and Nucleotide Descriptors
Open AccessArticle

Alteration of Intestinal Flora Stimulates Pulmonary microRNAs to Interfere with Host Antiviral Immunity in Influenza

by Peng Pang 1,†, Bin Yu 1,2,†, Yucong Shi 1, Li Deng 1, Huachong Xu 1, Sizhi Wu 1 and Xiaoyin Chen 1,*
1
College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, Guangdong, China
2
College of Integrated Traditional Chinese and Western Medicine, Jining Medical University, Jining 272067, Shandong, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(12), 3151; https://doi.org/10.3390/molecules23123151
Received: 30 October 2018 / Revised: 18 November 2018 / Accepted: 29 November 2018 / Published: 30 November 2018
(This article belongs to the Special Issue Recent Advances in the Development of Antiviral Agents)
The intestinal flora may be an important and modifiable factor that contributes to the immune response in influenza. To investigate the effect of intestinal flora alteration induced by antibiotic interference on microRNA (miRNA) communication in antiviral immunity, BALB/c mice received two weeks of antibiotic treatment before infection with the influenza A virus. The changes in intestinal flora and pulmonary flora were detected and analyzed by 16S ribosomal RNA (rRNA) gene sequencing. The amplification of the influenza virus in the lungs was measured by RT-PCR. The involvement of pulmonary miRNA was explored using miRNA microarray analysis. The results showed that the antibiotics destroyed the symbiotic relationship of the intestinal flora, resulting in a reduction in bacterial diversity, but they did not affect the pulmonary flora. The alteration of intestinal flora affected the expression of pulmonary miRNAs and resulted in an enhancement of pulmonary influenza virus amplification. The conclusion is that alteration of intestinal flora induced by antibiotic interference affected the expression of pulmonary miRNAs to interfere with host antiviral immunity, of which miR-146b and miR-29c might be good resources of resistance to influenza under antibiotic abuse. View Full-Text
Keywords: intestinal flora; microRNAs; influenza; antibiotic abuse; antiviral immunity intestinal flora; microRNAs; influenza; antibiotic abuse; antiviral immunity
Show Figures

Figure 1

MDPI and ACS Style

Pang, P.; Yu, B.; Shi, Y.; Deng, L.; Xu, H.; Wu, S.; Chen, X. Alteration of Intestinal Flora Stimulates Pulmonary microRNAs to Interfere with Host Antiviral Immunity in Influenza. Molecules 2018, 23, 3151.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop