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Open AccessArticle

Effect of Photodynamic Antibacterial Chemotherapy Combined with Antibiotics on Gram-Positive and Gram-Negative Bacteria

Department of Chemical Engineering, Biotechnology and Materials, Ariel University, Ariel 4070000, Israel
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 117977 Moscow, Russia
Clinical Microbiology Laboratory, Meir Medical Center, Kfar Saba 4428164, Israel
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3152;
Received: 30 October 2018 / Revised: 23 November 2018 / Accepted: 27 November 2018 / Published: 30 November 2018
(This article belongs to the Section Medicinal Chemistry)
The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitive and resistant strains of P. aeruginosa were eradicated by Rose Bengal under illumination and by sulfanilamide but were not inhibited by new sulfanilamide derivatives. No increase in sensitivity of P. aeruginosa cells to sulfanilamide was observed upon a combination of Rose Bengal and sulfanilamide under illumination. All tested S. aureus strains (MSSA and MRSA) were effectively inhibited by PACT. When treated with sub-MIC concentrations of Rose Bengal under illumination, the minimum inhibitory concentrations (MIC) of methicillin decreased significantly for MSSA and MRSA strains. In some cases, antibiotic sensitivity of resistant strains can be restored by combining antibiotics with PACT. View Full-Text
Keywords: antibiotic resistance; Rose Bengal; PACT; sulfanilamide derivatives antibiotic resistance; Rose Bengal; PACT; sulfanilamide derivatives
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Ilizirov, Y.; Formanovsky, A.; Mikhura, I.; Paitan, Y.; Nakonechny, F.; Nisnevitch, M. Effect of Photodynamic Antibacterial Chemotherapy Combined with Antibiotics on Gram-Positive and Gram-Negative Bacteria. Molecules 2018, 23, 3152.

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