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Molecules 2017, 22(6), 966;

Dichlorotrifluoromethoxyacetic Acid: Preparation and Reactivity

Institut Lavoisier de Versailles (ILV), UMR CNRS 8180, Université de Versailles, 45 avenue des Etats-Unis, 78035 Versailles CEDEX, France
Infectiologie et Santé Publique (ISP), UMR 1282 INRA/Université de Tours (UFR Sciences & Techniques), Parc de Grandmont, 37200 Tours, France
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans’ka Str. 5, 02094 Kyiv, Ukraine
Dedicated to the Memory of Academician Professor Valeriy Kukhar.
Author to whom correspondence should be addressed.
Academic Editor: Thierry Billard
Received: 28 April 2017 / Revised: 6 June 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
Full-Text   |   PDF [720 KB, uploaded 13 June 2017]   |  


We describe the first gram scale preparation of the reagent dichlorotrifluoromethoxyacetic acid. This stable compound is obtained in five steps starting from the cheap diethylene glycol. The reactivity of the sodium salt of this fluorinated acid was also tested and allowed the preparation of new amides. View Full-Text
Keywords: fluorine; trifluoromethoxy; amides fluorine; trifluoromethoxy; amides

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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MDPI and ACS Style

Zriba, R.; Desmarchelier, A.; Cadoret, F.; Bouvet, S.; Barthelemy, A.-L.; Pégot, B.; Diter, P.; Dagousset, G.; Blazejewski, J.-C.; Anselmi, E.; Yagupolskii, Y.; Magnier, E. Dichlorotrifluoromethoxyacetic Acid: Preparation and Reactivity. Molecules 2017, 22, 966.

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