Next Article in Journal
Ugonin M, a Helminthostachys zeylanica Constituent, Prevents LPS-Induced Acute Lung Injury through TLR4-Mediated MAPK and NF-κB Signaling Pathways
Previous Article in Journal
Sulfur-Doped Carbon Nitride Polymers for Photocatalytic Degradation of Organic Pollutant and Reduction of Cr(VI)
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(4), 575;

Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens

Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China
Department of Traditional Chinese Medicine, Henan Province People's Hospital, Zhengzhou 450002, Henan, China
Author to whom correspondence should be addressed.
Received: 5 February 2017 / Revised: 29 March 2017 / Accepted: 30 March 2017 / Published: 1 April 2017
Full-Text   |   PDF [2195 KB, uploaded 24 April 2017]   |  


A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite–modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential in the redox process of MT, indicating the great enhancement of electrocatalytic activity toward the oxidation of MT by the composite of GNs and HA. Under the optimized conditions, the oxidation peak currents were related linearly with the concentration of MT, ranging from 2 μM to 3 mM, and the detection limit (S/N = 3) was 1.2 μM. In addition, the proposed electrochemical sensor can be successfully applied in the quantitative determination of MT in Sophora flavescens extract. View Full-Text
Keywords: matrine; voltammetric sensors; Sophora flavescens; electrochemistry; hydroxyapatite matrine; voltammetric sensors; Sophora flavescens; electrochemistry; hydroxyapatite

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Zhang, J.; Wang, Y.; Zheng, W. Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens. Molecules 2017, 22, 575.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top