Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry
AbstractFlavonoids from Sophora flavescens were selectively extracted by mechanochemical-promoted extraction technology (MPET) after using response surface methodology to determine the optimal extraction parameters. The highest yield of 35.17 mg/g was achieved by grinding the roots with Na2CO3 (15%) at 440 rpm/min for 17.0 min and water was used as the sole solvent with a ratio of solvent to solid material of 25 mL/g. Flavonoids prepared by MPET demonstrated relatively higher antioxidant activities in subsequent DPPH and hydroxyl radical scavenging assays. Main constituents in the extracts, including kurarinol, kushenol I/N and kurarinone, were characterized by HPLC-MS/MS, indicating good selective extraction by MPET. Physicochemical property changes of powder during mechanochemical milling were identified by scanning electron microscopy, X-ray powder diffraction, and UV-Vis diffuse-reflectance spectroscopy. Compared with traditional extraction methods, MPET possesses notable advantages of higher selectivity, lower extraction temperature, shorter extraction time, and organic solvent free properties. View Full-Text
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Zhang, Q.; Yu, J.; Wang, Y.; Su, W. Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry. Molecules 2016, 21, 989.
Zhang Q, Yu J, Wang Y, Su W. Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry. Molecules. 2016; 21(8):989.Chicago/Turabian Style
Zhang, Qihong; Yu, Jingbo; Wang, Yingyao; Su, Weike. 2016. "Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry." Molecules 21, no. 8: 989.
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