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Open AccessArticle

Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry

1
National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
2
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
*
Author to whom correspondence should be addressed.
Academic Editors: Koichi Komatsu and Carsten Bolm
Molecules 2016, 21(8), 989; https://doi.org/10.3390/molecules21080989
Received: 9 June 2016 / Revised: 15 July 2016 / Accepted: 22 July 2016 / Published: 29 July 2016
(This article belongs to the Special Issue Mechanochemistry)
Flavonoids from Sophora flavescens were selectively extracted by mechanochemical-promoted extraction technology (MPET) after using response surface methodology to determine the optimal extraction parameters. The highest yield of 35.17 mg/g was achieved by grinding the roots with Na2CO3 (15%) at 440 rpm/min for 17.0 min and water was used as the sole solvent with a ratio of solvent to solid material of 25 mL/g. Flavonoids prepared by MPET demonstrated relatively higher antioxidant activities in subsequent DPPH and hydroxyl radical scavenging assays. Main constituents in the extracts, including kurarinol, kushenol I/N and kurarinone, were characterized by HPLC-MS/MS, indicating good selective extraction by MPET. Physicochemical property changes of powder during mechanochemical milling were identified by scanning electron microscopy, X-ray powder diffraction, and UV-Vis diffuse-reflectance spectroscopy. Compared with traditional extraction methods, MPET possesses notable advantages of higher selectivity, lower extraction temperature, shorter extraction time, and organic solvent free properties. View Full-Text
Keywords: Sophora flavescens Ait.; flavonoids; mechanochemical-promoted extraction technology; response surface methodology; selectivity Sophora flavescens Ait.; flavonoids; mechanochemical-promoted extraction technology; response surface methodology; selectivity
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MDPI and ACS Style

Zhang, Q.; Yu, J.; Wang, Y.; Su, W. Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry. Molecules 2016, 21, 989.

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