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Molecules 2016, 21(4), 457;

Antimicrobial Diterpenoids of Wedelia trilobata (L.) Hitchc

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
Shanxi Zhendong Pharmaceutical Co., Ltd., Changzhi 047100, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 March 2016 / Revised: 28 March 2016 / Accepted: 30 March 2016 / Published: 7 April 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
Full-Text   |   PDF [1240 KB, uploaded 7 April 2016]   |  


Continued interest in the metabolites of Wedelia trilobata (L.) Hitchc, a notoriously invasive weed in South China, led to the isolation of twenty-six ent-kaurane diterpenoids, including seven new ones 1–7. Their structures and relative configuration were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR experiments. The antimicrobial activities of all isolated diterpenoids were evaluated against a panel of bacteria and fungi. View Full-Text
Keywords: invasive weed; Wedelia trilobata; ent-kaurane diterpenoids; antimicrobial invasive weed; Wedelia trilobata; ent-kaurane diterpenoids; antimicrobial

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Li, S.-F.; Ding, J.-Y.; Li, Y.-T.; Hao, X.-J.; Li, S.-L. Antimicrobial Diterpenoids of Wedelia trilobata (L.) Hitchc. Molecules 2016, 21, 457.

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