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Nanotechnology Formulations for Antibacterial Free Fatty Acids and Monoglycerides

School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore
Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Molecules 2016, 21(3), 305;
Received: 1 February 2016 / Revised: 17 February 2016 / Accepted: 23 February 2016 / Published: 3 March 2016
PDF [2918 KB, uploaded 3 March 2016]


Free fatty acids and monoglycerides have long been known to possess broad-spectrum antibacterial activity that is based on lytic behavior against bacterial cell membranes. Considering the growing challenges of drug-resistant bacteria and the need for new classes of antibiotics, the wide prevalence, affordable cost, and broad spectrum of fatty acids and monoglycerides make them attractive agents to develop for healthcare and biotechnology applications. The aim of this review is to provide a brief introduction to the history of antimicrobial lipids and their current status and challenges, and to present a detailed discussion of ongoing research efforts to develop nanotechnology formulations of fatty acids and monoglycerides that enable superior in vitro and in vivo performance. Examples of nano-emulsions, liposomes, solid lipid nanoparticles, and controlled release hydrogels are presented in order to highlight the potential that lies ahead for fatty acids and monoglycerides as next-generation antibacterial solutions. Possible application routes and future directions in research and development are also discussed. View Full-Text
Keywords: antimicrobial lipid; fatty acid; monoglyceride; nanotechnology; emulsion; liposome; solid lipid nanoparticle; hydrogel antimicrobial lipid; fatty acid; monoglyceride; nanotechnology; emulsion; liposome; solid lipid nanoparticle; hydrogel

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Jackman, J.A.; Yoon, B.K.; Li, D.; Cho, N.-J. Nanotechnology Formulations for Antibacterial Free Fatty Acids and Monoglycerides. Molecules 2016, 21, 305.

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