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Open AccessArticle

Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion

1
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain
2
Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain
3
Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid 28007, Spain
4
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, Madrid 28029, Spain
5
Servicio de Medicina Intensiva, Hospital Universitario de Getafe, Getafe, Madrid 28905, Spain
6
Universidad Europea de Madrid, Madrid 28905, Spain
7
Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Granada 18071, Spain
8
Centro de Investigaciones Biomédicas en Red de Enfermedades Cardiovasculares (Ciberec), Madrid 28029, Spain
9
Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, Madrid 28040, Spain
10
Servicio de Neumología, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid 28040, Spain
*
Author to whom correspondence should be addressed.
Both authors contributed equally.
Academic Editors: Celestino Santos-Buelga and Arturo San Feliciano
Molecules 2016, 21(12), 1739; https://doi.org/10.3390/molecules21121739
Received: 6 October 2016 / Revised: 30 November 2016 / Accepted: 7 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Flavonoids: From Structure to Health Issues)
Background: We hypothesized that treatment with quercetin could result in improved hemodynamics, lung inflammatory parameters and mortality in a rat model of hemorrhagic shock. Methods: Rats were anesthetized (80 mg/kg ketamine plus 8 mg/kg xylazine i.p.). The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg/kg) or vehicle were administered during resuscitation. Results: There was a trend for increased survival 84.6% (11/13) in the treated group vs. the shock group 68.4% (13/19, p > 0.05 Kaplan–Meier). Quercetin fully prevented the development of lung edema. The activity of aSMase was increased in the shock group compared to the sham group and the quercetin prevented this effect. However, other inflammatory markers such as myeloperoxidase activity, interleukin-6 in plasma or bronchoalveolar fluid were similar in the sham and shock groups. We found no bacterial DNA in plasma in these animals. Conclusions: Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion. View Full-Text
Keywords: systemic arterial pressure; lung edema; hemorrhage; trauma; reperfusion systemic arterial pressure; lung edema; hemorrhage; trauma; reperfusion
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Chamorro, V.; Pandolfi, R.; Moreno, L.; Barreira, B.; Martínez-Ramas, A.; Morales-Cano, D.; Ruiz-Cabello, J.; Lorente, J.A.; Duarte, J.; Cogolludo, Á.; Alvarez-Sala, J.L.; Perez-Vizcaino, F. Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion. Molecules 2016, 21, 1739.

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