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Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery
Open AccessReview

Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
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Academic Editor: Diego Muñoz-Torrero
Molecules 2016, 21(12), 1715; https://doi.org/10.3390/molecules21121715
Received: 15 September 2016 / Revised: 26 November 2016 / Accepted: 6 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Stimuli-Responsive Biomaterials in Biomedical Applications)
Benefiting from the development of nanotechnology, drug delivery systems (DDSs) with stimuli-responsive controlled release function show great potential in clinical anti-tumor applications. By using a DDS, the harsh side effects of traditional anti-cancer drug treatments and damage to normal tissues and organs can be avoided to the greatest extent. An ideal DDS must firstly meet bio-safety standards and secondarily the efficiency-related demands of a large drug payload and controlled release function. This review highlights recent research progress on DDSs with stimuli-responsive characteristics. The first section briefly reviews the nanoscale scaffolds of DDSs, including mesoporous nanoparticles, polymers, metal-organic frameworks (MOFs), quantum dots (QDs) and carbon nanotubes (CNTs). The second section presents the main types of stimuli-responsive mechanisms and classifies these into two categories: intrinsic (pH, redox state, biomolecules) and extrinsic (temperature, light irradiation, magnetic field and ultrasound) ones. Clinical applications of DDS, future challenges and perspectives are also mentioned. View Full-Text
Keywords: drug delivery system; stimuli response; nanotechnology; anti-tumor treatment drug delivery system; stimuli response; nanotechnology; anti-tumor treatment
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MDPI and ACS Style

Ding, C.; Tong, L.; Feng, J.; Fu, J. Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment. Molecules 2016, 21, 1715.

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