Next Article in Journal
Recent Advances in Olefin Metathesis
Previous Article in Journal
Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion
Previous Article in Special Issue
Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Molecules 2016, 21(12), 1715;

Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 15 September 2016 / Revised: 26 November 2016 / Accepted: 6 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Stimuli-Responsive Biomaterials in Biomedical Applications)
Full-Text   |   PDF [1852 KB, uploaded 20 December 2016]   |  


Benefiting from the development of nanotechnology, drug delivery systems (DDSs) with stimuli-responsive controlled release function show great potential in clinical anti-tumor applications. By using a DDS, the harsh side effects of traditional anti-cancer drug treatments and damage to normal tissues and organs can be avoided to the greatest extent. An ideal DDS must firstly meet bio-safety standards and secondarily the efficiency-related demands of a large drug payload and controlled release function. This review highlights recent research progress on DDSs with stimuli-responsive characteristics. The first section briefly reviews the nanoscale scaffolds of DDSs, including mesoporous nanoparticles, polymers, metal-organic frameworks (MOFs), quantum dots (QDs) and carbon nanotubes (CNTs). The second section presents the main types of stimuli-responsive mechanisms and classifies these into two categories: intrinsic (pH, redox state, biomolecules) and extrinsic (temperature, light irradiation, magnetic field and ultrasound) ones. Clinical applications of DDS, future challenges and perspectives are also mentioned. View Full-Text
Keywords: drug delivery system; stimuli response; nanotechnology; anti-tumor treatment drug delivery system; stimuli response; nanotechnology; anti-tumor treatment

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ding, C.; Tong, L.; Feng, J.; Fu, J. Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment. Molecules 2016, 21, 1715.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top