Next Article in Journal
Ribosome-Inactivating Proteins from Plants: A Historical Overview
Next Article in Special Issue
Enhanced Stilbene Production and Excretion in Vitis vinifera cv Pinot Noir Hairy Root Cultures
Previous Article in Journal
A Method for Determining the Content of Glycoproteins in Biological Samples
Previous Article in Special Issue
Simultaneous Ultra Performance Liquid Chromatography Determination and Antioxidant Activity of Linarin, Luteolin, Chlorogenic Acid and Apigenin in Different Parts of Compositae Species
Open AccessReview

Antiproliferative Effect of Indole Phytoalexins

Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, 040 11 Košice, Slovakia
Department of Human and Clinical Pharmacology, University of Veterinary Medicine and Pharmacy, 040 11 Košice, Slovakia
Department of Animal Breeding, University of Veterinary Medicine and Pharmacy, 040 11 Košice, Slovakia
Author to whom correspondence should be addressed.
Academic Editor: Philippe Jeandet
Molecules 2016, 21(12), 1626;
Received: 18 October 2016 / Revised: 15 November 2016 / Accepted: 22 November 2016 / Published: 26 November 2016
Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant family producing sulfur-containing indole phytoalexins. The mechanisms underlying its anti-cancer properties are unknown. Isolation from cruciferous plants does not provide sufficient quantities of indole phytoalexins and, for biological screening, they are usually obtainable through synthesis. Understanding the molecular mechanism of the action of these substances and their structure-activity relationships is quite important in the development of new analogs with a more favorable profile of biological activities. In this review, we present the key features of indole phytoalexins, mainly their antiproliferative ativities. View Full-Text
Keywords: indole phytoalexins; crucifers; brassinin; antiproliferative; cancer indole phytoalexins; crucifers; brassinin; antiproliferative; cancer
Show Figures

Figure 1

MDPI and ACS Style

Chripkova, M.; Zigo, F.; Mojzis, J. Antiproliferative Effect of Indole Phytoalexins. Molecules 2016, 21, 1626.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop