Next Article in Journal
Application of Ultra-High-Performance Liquid Chromatography Coupled with LTQ-Orbitrap Mass Spectrometry for the Qualitative and Quantitative Analysis of Polygonum multiflorum Thumb. and Its Processed Products
Next Article in Special Issue
Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
Previous Article in Journal
Mini Review of Phytochemicals and Plant Taxa with Activity as Microbial Biofilm and Quorum Sensing Inhibitors
Previous Article in Special Issue
Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
Open AccessArticle

Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40

1
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
4
Laboratory of State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Molecules 2016, 21(1), 34; https://doi.org/10.3390/molecules21010034
Received: 2 November 2015 / Revised: 18 December 2015 / Accepted: 21 December 2015 / Published: 26 December 2015
(This article belongs to the Collection Bioactive Compounds)
Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge–derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (17) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC50 values of 6.2 ± 0.08 and 8.9 ± 0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC50 value of 3.5 ± 1.3 μM. View Full-Text
Keywords: sponge-derived fungus; asteltoxins; antiviral (H1N1 and H3N2) activity sponge-derived fungus; asteltoxins; antiviral (H1N1 and H3N2) activity
Show Figures

Graphical abstract

MDPI and ACS Style

Tian, Y.-Q.; Lin, X.-P.; Wang, Z.; Zhou, X.-F.; Qin, X.-C.; Kaliyaperumal, K.; Zhang, T.-Y.; Tu, Z.-C.; Liu, Y. Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40. Molecules 2016, 21, 34. https://doi.org/10.3390/molecules21010034

AMA Style

Tian Y-Q, Lin X-P, Wang Z, Zhou X-F, Qin X-C, Kaliyaperumal K, Zhang T-Y, Tu Z-C, Liu Y. Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40. Molecules. 2016; 21(1):34. https://doi.org/10.3390/molecules21010034

Chicago/Turabian Style

Tian, Yong-Qi; Lin, Xiu-Ping; Wang, Zhen; Zhou, Xue-Feng; Qin, Xiao-Chu; Kaliyaperumal, Kumaravel; Zhang, Tian-Yu; Tu, Zheng-Chao; Liu, Yonghong. 2016. "Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40" Molecules 21, no. 1: 34. https://doi.org/10.3390/molecules21010034

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop