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Open AccessArticle

Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

by Yu Wang 1, Da-Hong Li 2,3, Zhan-Lin Li 2,3, Yan-Jun Sun 4, Hui-Ming Hua 2,3, Tao Liu 1,* and Jiao Bai 2,3,*
1
Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110122, China
2
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
3
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
4
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Molecules 2016, 21(1), 31; https://doi.org/10.3390/molecules21010031
Received: 29 November 2015 / Revised: 17 December 2015 / Accepted: 21 December 2015 / Published: 28 December 2015
(This article belongs to the Collection Bioactive Compounds)
Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 35. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM. View Full-Text
Keywords: marine-derived fungus; Aspergillus fumigatus; terpenoid; cell growth inhibition marine-derived fungus; Aspergillus fumigatus; terpenoid; cell growth inhibition
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Wang, Y.; Li, D.-H.; Li, Z.-L.; Sun, Y.-J.; Hua, H.-M.; Liu, T.; Bai, J. Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7. Molecules 2016, 21, 31.

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