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Open AccessArticle

New Anticandidous 2-Alkylthio-6-aminobenzothiazoles

1
Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina, SK-842 15 Bratislava, Slovak Republic
2
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Mlynská dolina, SK-842 15 Bratislava, Slovak Republic
*
Author to whom correspondence should be addressed.
Molecules 1997, 2(2), 36-42; https://doi.org/10.3390/feb97p2
Received: 19 October 1996 / Accepted: 26 November 1996 / Published: 25 February 1997
The synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compounds have shown antibacterial activity against Staphylococcus aureus and anticandidous activity against Candida albicans. The optimum structure of the studied compounds has been calculated by quantum chemistry AM1 method. The theoretical values of lipophilicity were calculated for all alkenyl substituents. View Full-Text
Keywords: 2-Alkenylthio-6-aminobenzothiazoles; anticandidous; antibacterial; AM1 calculations; lipophilicity 2-Alkenylthio-6-aminobenzothiazoles; anticandidous; antibacterial; AM1 calculations; lipophilicity
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Sidóová, E.; Loos, D.; Bujdáková, H.; Kallová, J. New Anticandidous 2-Alkylthio-6-aminobenzothiazoles. Molecules 1997, 2, 36-42.

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