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Molecules 2014, 19(4), 4076-4082; https://doi.org/10.3390/molecules19044076

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

1
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
2
Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 21 March 2014 / Accepted: 24 March 2014 / Published: 2 April 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 28 in a single step. View Full-Text
Keywords: chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer chemoselective; alkylation; microwave; adenosine A3; PET; radiotracer
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Shanab, K.; Neudorfer, C.; Holzer, W.; Mitterhauser, M.; Wadsak, W.; Spreitzer, H. A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer. Molecules 2014, 19, 4076-4082.

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