Hydrological regionalization is a useful step in hydrological modeling and prediction. The regionalization is not always straightforward, however, due to the lack of long-term hydrological data and the complex multi-scale variability features embedded in the data. This study examines the multiscale soil moisture variability for the simulated data on a grid cell base obtained from a large-scale hydrological model, and clusters the grid-cell based soil moisture data using wavelet-based multiscale entropy and principal component analysis, over the Xijiang River basin in South China, for the period of 2002–2010. The effective regionalization, for 169 grid cells with the special resolution of 0.5° × 0.5°, produced homogeneous groups based on the pattern of wavelet-based entropy information. Four distinct modes explain 80.14% of the total embedded variability of the transformed wavelet power across different timescales. Moreover, the possible implications of the regionalization results for local hydrological applications, such as parameter estimation for an ungagged catchment and designing a uniform prediction strategy for a sub-area in a large-scale basin, are discussed.
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