Special Issue "Natural Products as Leads or Drugs against Neglected Tropical Diseases"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 15 March 2014
Prof. Dr. Thomas J. Schmidt
Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Corrensstrasse 48, D-48149 Münster, Germany
Interests: natural products; anti-parasitic activity; structure elucidation; spectroscopy; computer-aided structure-activity relationship studies
About one billion people world-wide suffer from at least one of 17 life-threatening diseases currently classified by WHO as Neglected Tropical Diseases (NTDs). These diseases represent a major cause of morbidity, disability and mortality in tropical regions of the world. They are termed “neglected” due to lack of financial investment into research and development of new drugs and almost non-existent public awareness in high-income countries. Being associated with poor socioeconomic and hygienic circumstances, they could also be termed diseases of neglected populations. NTDs comprise infections with pathogens of bacterial (e.g., Leprosy, Trachoma), viral (Dengue fever), helminth (e.g., Schistosomiasis, Filariasis) as well as “protozoan” (African sleeping sickness, Chagas’ disease, Leishmaniasis) origin. In environments where NTDs prevail, Malaria, the most widespread “protozoan” infection—although not currently treated as such by WHO—can also be considered a neglected disease. Notwithstanding recent partial successes in the struggle to eliminate or even eradicate some of these diseases, which have been achieved by WHO’s consequent strategies of disease monitoring, vector control, preventive chemotherapy and others, the development of new, safe and affordable drugs remains an urgent need. Existing pharmacotherapies, especially in case of the “protozoan” parasitoses, suffer from various shortcomings, namely, a high degree of toxicity and unwanted effects, lack of availability and/or problematic application under the life conditions of affected populations, as well as emergence of resistant pathogens, so that the search for new chemical entities showing activity against the NTD-pathogens is a very important field of research.
Nature has provided an innumerable wealth of drugs for the treatment of many serious diseases. Among the natural sources for new bioactive chemicals, terrestrial plants, bacteria and fungi have traditionally played the major roles; however, increasingly over the past few decades, many interesting new active molecules are found in marine life forms. Secondary metabolites from an immense diversity of living organisms thus represent a huge repository of chemical structures which has been and will continue to be a source of new drugs, directly in their native form or after optimization by synthetic medicinal chemistry.
The present Special Issue focuses on such molecules of natural origin that show a promising potential to act against the pathogens responsible for neglected tropical diseases, including Malaria. All aspects related to the discovery and further development of natural products against NTDs will be covered by the issue. It is therefore a pleasure to invite high quality studies, as well as timely review papers, on in vitro and in vivo biological activity, isolation and structure elucidation, synthetic optimization, investigations of the pharmacodynamics and -kinetics, as well as structure-activity relationships of natural products acting against NTDs.
Prof. Dr. Thomas J. Schmidt
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- neglected tropical disease
- natural product
- secondary metabolite
- medicinal chemistry of natural products
- bioactivity testing/screening
- mechanism of action
- chagas disease
- human african trypanosomiasis (Sleeping sickness)
- buruli ulcer (mycobacterium ulcerans infection)
- dracunculiasis (guinea-worm disease)
- foodborne trematodiases
- lymphatic filariasis
- onchocerciasis (river blindness)
- soil transmitted helminthiases
- yaws (endemic treponematoses)
Article: Antileishmanial Lead Structures from Nature: Analysis of Structure-Activity Relationships of a Compound Library Derived from Caffeic Acid Bornyl Ester
Molecules 2014, 19(2), 1394-1410; doi:10.3390/molecules19021394
Received: 23 December 2013; in revised form: 13 January 2014 / Accepted: 13 January 2014 / Published: 27 January 2014| Download PDF Full-text (451 KB) | Download XML Full-text
Article: Synthetic Fosmidomycin Analogues with Altered Chelating Moieties Do Not Inhibit 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum Growth In Vitro
Molecules 2014, 19(2), 2571-2587; doi:10.3390/molecules19022571
Received: 6 February 2014; in revised form: 18 February 2014 / Accepted: 19 February 2014 / Published: 24 February 2014| Download PDF Full-text (387 KB)
Last update: 7 October 2013