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Molecules 2018, 23(1), 150; https://doi.org/10.3390/molecules23010150

Arnica Tincture Cures Cutaneous Leishmaniasis in Golden Hamsters

1
PECET-School of Medicine, University of Antioquia, Calle 70 # 52-21, 0500100 Medellin, Colombia
2
Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus-Corrensstrasse 48, D-48149 Münster, Germany
*
Author to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 9 January 2018 / Accepted: 11 January 2018 / Published: 12 January 2018
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Abstract

In search for potential therapeutic alternatives to existing treatments for cutaneous Leishmaniasis, we have investigated the effect of Arnica tincture Ph. Eur. (a 70% hydroethanolic tincture prepared from flowerheads of Arnica montana L.) on the lesions caused by infection with Leishmania braziliensis in a model with golden hamsters. The animals were treated topically with a daily single dose of the preparation for 28 days. Subsequently, the healing process was monitored by recording the lesion size in intervals of 15 days up to day 90. As a result, Arnica tincture fully cured three out of five hamsters while one animal showed an improvement and another one suffered from a relapse. This result was slightly better than that obtained with the positive control, meglumine antimonate, which cured two of five hamsters while the other three showed a relapse after 90 days. This result encourages us to further investigate the potential of Arnica tincture in the treatment of cutaneous Leishmaniasis. View Full-Text
Keywords: Arnica montana L.; cutaneous Leishmaniasis; neglected tropical disease Arnica montana L.; cutaneous Leishmaniasis; neglected tropical disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Robledo, S.M.; Vélez, I.D.; Schmidt, T.J. Arnica Tincture Cures Cutaneous Leishmaniasis in Golden Hamsters. Molecules 2018, 23, 150.

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