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Molecules 2014, 19(5), 5470-5477; doi:10.3390/molecules19055470

Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)

Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria
Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria
Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, D-40225 Dusseldorf, Germany
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Insitute, CH-4002 Basel, Switzerland
Department of Medical Parasitology, University of Basel, CH-4003 Basel, Switzerland
Author to whom correspondence should be addressed.
Received: 18 March 2014 / Revised: 21 April 2014 / Accepted: 22 April 2014 / Published: 25 April 2014
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Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of the crude extract. In this study, two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extract of Zapoteca portoricensis and their chemical structures deduced by one dimensional and two dimensional NMR and mass spectrometry. These compounds were isolated for the first time from this plant, and no report has been found on their previous isolation from the genus Zapoteca. Evaluation of their trypanocidal activity showed that compound 1 exhibited potent activity against Trypanosoma brucei rhodesiense with an IC50 value of 3.63 μM and selectivity index of 25.3.
Keywords: Zapoteca portoricensis; dipeptides; isolation; fabaceae; trypanocidal acitivity Zapoteca portoricensis; dipeptides; isolation; fabaceae; trypanocidal acitivity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nwodo, N.J.; Okoye, F.B.C.; Lai, D.; Debbab, A.; Brun, R.; Proksch, P. Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae). Molecules 2014, 19, 5470-5477.

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