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Molecules 2017, 22(9), 1514; doi:10.3390/molecules22091514

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

1
Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya
2
Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI)—Walter Reed Project, Kisumu and Nairobi, P.O. Box 54-40100, Kisumu, Kenya
3
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.O. Box 999078, China
4
Department of Chemistry and Molecular Biology, University of Gothenburg, SE-40530 Gothenburg, Sweden
5
Swedish NMR Centre, University of Gothenburg, P.O. Box 465, SE-40530 Gothenburg, Sweden
*
Authors to whom correspondence should be addressed.
Received: 28 July 2017 / Revised: 28 August 2017 / Accepted: 6 September 2017 / Published: 10 September 2017
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Abstract

Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (511), were isolated from the CH2Cl2/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC50 1.7 ± 0.1 μM, with relatively low cytotoxicity, IC50 > 21 μM, against four cell-lines. View Full-Text
Keywords: Tephrosia purpurea subsp. leptostachya; stem; flavone; antiplasmodial; cytotoxicity Tephrosia purpurea subsp. leptostachya; stem; flavone; antiplasmodial; cytotoxicity
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MDPI and ACS Style

Atilaw, Y.; Muiva-Mutisya, L.; Ndakala, A.; Akala, H.M.; Yeda, R.; Wu, Y.J.; Coghi, P.; Wong, V.K.W.; Erdélyi, M.; Yenesew, A. Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya. Molecules 2017, 22, 1514.

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