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Molecules 2014, 19(12), 21276-21290; doi:10.3390/molecules191221276

Insecticidal Activities of Bark, Leaf and Seed Extracts of Zanthoxylum heitzii against the African Malaria Vector Anopheles gambiae

1
Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, P.O. Box 5003, Ås 1432, Norway
2
Department of Entomology, Faculty of Agriculture, Kasetsart University, 50 Ngam Wong Wan Rd, Ladyaow, Chatuchak, Bangkok 10900, Thailand
3
Institut de Recherche pour le Développement (IRD), Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (IRD 224-CNRS 5290 UM1-UM2), Montpellier Cedex 5 34394, France
4
National Polytechnic High School, Marien Ngouabi University, BP 69, Brazzaville, Congo
5
School of Pharmacy, Department of Pharmaceutical Chemistry, Section Pharmacognosy, University of Oslo, P.O. Box 1068 Blindern, Oslo 0316, Norway
*
Author to whom correspondence should be addressed.
Received: 16 October 2014 / Revised: 5 December 2014 / Accepted: 9 December 2014 / Published: 17 December 2014
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Abstract

The olon tree, Zanthoxylum heitzii (syn. Fagara heitzii) is commonly found in the central-west African forests. In the Republic of Congo (Congo-Brazzaville) its bark is anecdotally reported to provide human protection against fleas. Here we assess the insecticidal activities of Z. heitzii stem bark, seed and leaf extracts against Anopheles gambiae s.s, the main malaria vector in Africa. Extracts were obtained by Accelerated Solvent Extraction (ASE) using solvents of different polarity and by classical Soxhlet extraction using hexane as solvent. The insecticidal effects of the crude extracts were evaluated using topical applications of insecticides on mosquitoes of a susceptible reference strain (Kisumu [Kis]), a strain homozygous for the L1014F kdr mutation (kdrKis), and a strain homozygous for the G119S Ace1R allele (AcerKis). The insecticidal activities were measured using LD50 and LD95 and active extracts were characterized by NMR spectroscopy and HPLC chromatography. Results show that the ASE hexane stem bark extract was the most effective compound against An. gambiae (LD50 = 102 ng/mg female), but was not as effective as common synthetic insecticides. Overall, there was no significant difference between the responses of the three mosquito strains to Z. heitzii extracts, indicating no cross resistance with conventional pesticides. View Full-Text
Keywords: Zanthoxylum heitzii; Anopheles; malaria; bark extract; insecticide Zanthoxylum heitzii; Anopheles; malaria; bark extract; insecticide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Overgaard, H.J.; Sirisopa, P.; Mikolo, B.; Malterud, K.E.; Wangensteen, H.; Zou, Y.-F.; Paulsen, B.S.; Massamba, D.; Duchon, S.; Corbel, V.; Chandre, F. Insecticidal Activities of Bark, Leaf and Seed Extracts of Zanthoxylum heitzii against the African Malaria Vector Anopheles gambiae. Molecules 2014, 19, 21276-21290.

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