A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls
AbstractThe search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.
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Rapado, L.N.; Freitas, G.C.; Polpo, A.; Rojas-Cardozo, M.; Rincón, J.V.; Scotti, M.T.; Kato, M.J.; Nakano, E.; Yamaguchi, L.F. A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls. Molecules 2014, 19, 5205-5218.
Rapado LN, Freitas GC, Polpo A, Rojas-Cardozo M, Rincón JV, Scotti MT, Kato MJ, Nakano E, Yamaguchi LF. A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls. Molecules. 2014; 19(4):5205-5218.Chicago/Turabian Style
Rapado, Ludmila N.; Freitas, Giovana C.; Polpo, Adriano; Rojas-Cardozo, Maritza; Rincón, Javier V.; Scotti, Marcus T.; Kato, Massuo J.; Nakano, Eliana; Yamaguchi, Lydia F. 2014. "A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls." Molecules 19, no. 4: 5205-5218.