Molecules 2014, 19(4), 5205-5218; doi:10.3390/molecules19045205
Article

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Received: 11 March 2014; in revised form: 11 April 2014 / Accepted: 15 April 2014 / Published: 23 April 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.
Keywords: schistosomiasis; molluscicide; benzoic acid; flavokawain; Piper
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MDPI and ACS Style

Rapado, L.N.; Freitas, G.C.; Polpo, A.; Rojas-Cardozo, M.; Rincón, J.V.; Scotti, M.T.; Kato, M.J.; Nakano, E.; Yamaguchi, L.F. A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls. Molecules 2014, 19, 5205-5218.

AMA Style

Rapado LN, Freitas GC, Polpo A, Rojas-Cardozo M, Rincón JV, Scotti MT, Kato MJ, Nakano E, Yamaguchi LF. A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls. Molecules. 2014; 19(4):5205-5218.

Chicago/Turabian Style

Rapado, Ludmila N.; Freitas, Giovana C.; Polpo, Adriano; Rojas-Cardozo, Maritza; Rincón, Javier V.; Scotti, Marcus T.; Kato, Massuo J.; Nakano, Eliana; Yamaguchi, Lydia F. 2014. "A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls." Molecules 19, no. 4: 5205-5218.

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