Next Article in Journal
Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans
Next Article in Special Issue
Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)
Previous Article in Journal
Anti-Amoebic Properties of Carbonyl Thiourea Derivatives
Previous Article in Special Issue
Antiprotozoal Activities of Millettia richardiana (Fabaceae) from Madagascar
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(4), 5205-5218; doi:10.3390/molecules19045205

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil
Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo, SP, CEP 05508-000, Brazil
Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil
Departamento de Estatística, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Via Washington Luís, km 235, Sao Carlos, SP, Caixa-postal 676, CEP 13565-905, Brazil
Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia
Centro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba, Campus IV, Rua da Mangueira, s/n, Rio Tinto, PB, CEP 5829-7000, Brazil
These authors contributed equally to the organization of this article.
Authors to whom correspondence should be addressed.
Received: 11 March 2014 / Revised: 11 April 2014 / Accepted: 15 April 2014 / Published: 23 April 2014
View Full-Text   |   Download PDF [970 KB, uploaded 18 June 2014]   |  


The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails. View Full-Text
Keywords: schistosomiasis; molluscicide; benzoic acid; flavokawain; Piper schistosomiasis; molluscicide; benzoic acid; flavokawain; Piper

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rapado, L.N.; Freitas, G.C.; Polpo, A.; Rojas-Cardozo, M.; Rincón, J.V.; Scotti, M.T.; Kato, M.J.; Nakano, E.; Yamaguchi, L.F. A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls. Molecules 2014, 19, 5205-5218.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top