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Molecules 2014, 19(4), 5205-5218; doi:10.3390/molecules19045205

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

1,2,* , 3
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1,†,*  and 3,†
Received: 11 March 2014 / Revised: 11 April 2014 / Accepted: 15 April 2014 / Published: 23 April 2014
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The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.
Keywords: schistosomiasis; molluscicide; benzoic acid; flavokawain; Piper schistosomiasis; molluscicide; benzoic acid; flavokawain; Piper
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Rapado, L.N.; Freitas, G.C.; Polpo, A.; Rojas-Cardozo, M.; Rincón, J.V.; Scotti, M.T.; Kato, M.J.; Nakano, E.; Yamaguchi, L.F. A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls. Molecules 2014, 19, 5205-5218.

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