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Molecules 2016, 21(10), 1389; doi:10.3390/molecules21101389

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases—Part III: In-Silico Molecular Docking Investigations

1
Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA
2
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 16 September 2016 / Revised: 6 October 2016 / Accepted: 12 October 2016 / Published: 19 October 2016

Abstract

Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to cause considerable suffering and death in developing countries. Current treatment options for these parasitic protozoal diseases generally have severe side effects, may be ineffective or unavailable, and resistance is emerging. There is a constant need to discover new chemotherapeutic agents for these parasitic infections, and natural products continue to serve as a potential source. This review presents molecular docking studies of potential phytochemicals that target key protein targets in Leishmania spp., Trypanosoma spp., and Plasmodium spp. View Full-Text
Keywords: Leishmania; Trypanosoma; Plasmodium; natural products drug discovery Leishmania; Trypanosoma; Plasmodium; natural products drug discovery
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Ogungbe, I.V.; Setzer, W.N. The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases—Part III: In-Silico Molecular Docking Investigations. Molecules 2016, 21, 1389.

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