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Molecules 2014, 19(7), 10546-10562; doi:10.3390/molecules190710546

Hologram QSAR Studies of Antiprotozoal Activities of Sesquiterpene Lactones

1
Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Lineu Prestes, 580, 05508-000 São Paulo, Brazil
2
Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, Pharma Campus, Corrensstraße 48, D-48149 Münster, Germany
*
Author to whom correspondence should be addressed.
Received: 4 April 2014 / Revised: 8 July 2014 / Accepted: 9 July 2014 / Published: 18 July 2014
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Abstract

Infectious diseases such as trypanosomiasis and leishmaniasis are considered neglected tropical diseases due the lack for many years of research and development into new drug treatments besides the high incidence of mortality and the lack of current safe and effective drug therapies. Natural products such as sesquiterpene lactones have shown activity against T. brucei and L. donovani, the parasites responsible for these neglected diseases. To evaluate structure activity relationships, HQSAR models were constructed to relate a series of 40 sesquiterpene lactones (STLs) with activity against T. brucei, T. cruzi, L. donovani and P. falciparum and also with their cytotoxicity. All constructed models showed good internal (leave-one-out q2 values ranging from 0.637 to 0.775) and external validation coefficients (r2test values ranging from 0.653 to 0.944). From HQSAR contribution maps, several differences between the most and least potent compounds were found. The fragment contribution of PLS-generated models confirmed the results of previous QSAR studies that the presence of α,β-unsatured carbonyl groups is fundamental to biological activity. QSAR models for the activity of these compounds against T. cruzi, L. donovani and P. falciparum are reported here for the first time. The constructed HQSAR models are suitable to predict the activity of untested STLs. View Full-Text
Keywords: HQSAR; sesquiterpene lactones; Trypanosoma brucei; Trypanosoma cruzi; Leishmania donovani; Plasmodium falciparum; antiprotozoal activity; fragment-based drug design HQSAR; sesquiterpene lactones; Trypanosoma brucei; Trypanosoma cruzi; Leishmania donovani; Plasmodium falciparum; antiprotozoal activity; fragment-based drug design
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MDPI and ACS Style

Trossini, G.H.G.; Maltarollo, V.G.; Schmidt, T.J. Hologram QSAR Studies of Antiprotozoal Activities of Sesquiterpene Lactones. Molecules 2014, 19, 10546-10562.

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