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Molecules 2015, 20(3), 4180-4203; doi:10.3390/molecules20034180

Natural Products for the Treatment of Trachoma and Chlamydia trachomatis

1
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
2
Centre for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 15 December 2014 / Revised: 11 February 2015 / Accepted: 24 February 2015 / Published: 5 March 2015
View Full-Text   |   Download PDF [7225 KB, uploaded 5 March 2015]   |  

Abstract

The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities. View Full-Text
Keywords: trachoma; Chlamydia trachomatis; natural products; antibacterial trachoma; Chlamydia trachomatis; natural products; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Potroz, M.G.; Cho, N.-J. Natural Products for the Treatment of Trachoma and Chlamydia trachomatis. Molecules 2015, 20, 4180-4203.

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