Next Article in Journal
Catalytic Oxidation of Phenol and 2,4-Dichlorophenol by Using Horseradish Peroxidase Immobilized on Graphene Oxide/Fe3O4
Next Article in Special Issue
Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate
Previous Article in Journal
Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats
Previous Article in Special Issue
In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessCommunication
Molecules 2016, 21(8), 1045; doi:10.3390/molecules21081045

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

1
Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba
2
Parasitology Department, Institute of Tropical Medicine “Pedro Kouri” Marianao 13, Havana 10400, Cuba
3
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
4
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 June 2016 / Revised: 1 August 2016 / Accepted: 5 August 2016 / Published: 10 August 2016
View Full-Text   |   Download PDF [387 KB, uploaded 10 August 2016]   |  

Abstract

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity. View Full-Text
Keywords: Trametes versicolor; trametenolic acid B; antileishmanial activity Trametes versicolor; trametenolic acid B; antileishmanial activity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leliebre-Lara, V.; Monzote Fidalgo, L.; Pferschy-Wenzig, E.-M.; Kunert, O.; Nogueiras Lima, C.; Bauer, R. In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden). Molecules 2016, 21, 1045.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top