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Molecules 2016, 21(8), 1045; doi:10.3390/molecules21081045

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba
Parasitology Department, Institute of Tropical Medicine “Pedro Kouri” Marianao 13, Havana 10400, Cuba
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 June 2016 / Revised: 1 August 2016 / Accepted: 5 August 2016 / Published: 10 August 2016
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Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity. View Full-Text
Keywords: Trametes versicolor; trametenolic acid B; antileishmanial activity Trametes versicolor; trametenolic acid B; antileishmanial activity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Leliebre-Lara, V.; Monzote Fidalgo, L.; Pferschy-Wenzig, E.-M.; Kunert, O.; Nogueiras Lima, C.; Bauer, R. In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden). Molecules 2016, 21, 1045.

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