Next Article in Journal
The Role of microRNA in Head and Neck Cancer: Current Knowledge and Perspectives
Next Article in Special Issue
Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships
Previous Article in Journal
Synthesis and Antifungal Activity of Benzamidine Derivatives Carrying 1,2,3-Triazole Moieties
Previous Article in Special Issue
In-Silico Analyses of Sesquiterpene-Related Compounds on Selected Leishmania Enzyme-Based Targets
Molecules 2014, 19(5), 5692-5703; doi:10.3390/molecules19055692
Article

Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids

1,2
, 3
, 1,2
, 1
, 1
, 1,4
, 5
, 1
, 3
, 1
 and 1,*
Received: 15 March 2014; in revised form: 22 April 2014 / Accepted: 25 April 2014 / Published: 5 May 2014
View Full-Text   |   Download PDF [233 KB, updated 18 June 2014; original version uploaded 18 June 2014]   |   Browse Figure
Abstract: Leishmaniasis is one of the World’s most problematic diseases in developing countries. Traditional medicines to treat leishmaniasis have serious side effects, as well as significant parasite resistance problems. In this work, two alkaloids 1 and 2 were obtained from Corydalis govaniana Wall and seven alkaloids 39, were obtained from Erythrina verna. The structures of the compounds were confirmed by mass spectrometry and 1D- and 2D-NMR spectroscopy. The leishmanicidal activity of compounds 19 against Leishmania amazonensis was tested on promastigote forms and cytotoxicity against J774 (macrophage cell line) was assessed in vitro. Compound 1 showed potent activity (IC50 = 0.18 µg/mL), compared with the standard amphotericin B (IC50 = 0.20 µg/mL). The spirocyclic erythrina-alkaloids showed lower leishmanicidal activity than dibenzoquinolizine type alkaloids.
Keywords: Leishmania amazonensis; spirocyclic erythrina-alkaloids; tetrahydro-protoberberine-type alkaloids; Corydalis govaniana; Erythrina verna Leishmania amazonensis; spirocyclic erythrina-alkaloids; tetrahydro-protoberberine-type alkaloids; Corydalis govaniana; Erythrina verna
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Callejon, D.R.; Riul, T.B.; Feitosa, L.G.P.; Guaratini, T.; Silva, D.B.; Adhikari, A.; Shrestha, R.L.; Marques, L.M.M.; Baruffi, M.D.; Lopes, J.L.C.; Lopes, N.P. Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids. Molecules 2014, 19, 5692-5703.

AMA Style

Callejon DR, Riul TB, Feitosa LGP, Guaratini T, Silva DB, Adhikari A, Shrestha RL, Marques LMM, Baruffi MD, Lopes JLC, Lopes NP. Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids. Molecules. 2014; 19(5):5692-5703.

Chicago/Turabian Style

Callejon, Daniel R.; Riul, Thalita B.; Feitosa, Luis G.P.; Guaratini, Thais; Silva, Denise B.; Adhikari, Achyut; Shrestha, Ram L.; Marques, Lucas M.M.; Baruffi, Marcelo D.; Lopes, João L.C.; Lopes, Norberto P. 2014. "Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids." Molecules 19, no. 5: 5692-5703.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert