Research on Natural Bioactive Product-Based Pesticidal Agents—3rd Edition

Topic Information

Dear Colleagues,

At present, chemical pesticides remain an effective means to control pests. However, the consequent problems of pest resistance and resurgence, with serious repercussions such as chemical pesticide residues that impact food safety, human health, and the ecological environment, remain. Given that natural bioactive product-based pesticides originate from secondary metabolites of plants, fungi, bacteria, and other natural sources, which are produced under the selective forces driving co-evolution between organisms and the environment (life and non-life), they often experience less or slower resistance development and are more eco-friendly. Therefore, the application of natural bioactive products, which represent a priceless source of green pesticides, has received increasing attention. Conversely, when compared with chemical pesticides—to improve their agricultural properties—using them as lead compounds for structural optimization is highly desirable. Bioactive natural products, as an invaluable source for structural diversity and biological activity, can promote, either directly or indirectly, the discovery of green pesticide candidates. In particular, the study of their mechanisms of action against pests is also important for the development of pesticidal agents. 

Therefore, as a part of this Topic, entitled “Research on Natural Bioactive Product-Based Pesticidal Agents—3rd Edition”, we will present three recent achievements in this field, namely, the isolation and structural elucidation of natural bioactive products (NBPs), structural modification of NBPs, and discovery of the mechanisms of NBPs as pesticidal agents. Original research articles and review articles addressing major issues related to natural bioactive product-based pesticidal agents are welcome.

Prof. Dr. Min Lv
Prof. Dr. Hui Xu
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Agriculture agriculture	4.5	7.8	2011	17.4 Days	CHF 2600	Submit
Agrochemicals agrochemicals	-	11.5	2022	21.9 Days	CHF 1000	Submit
Agronomy agronomy	4.1	7.6	2011	17.7 Days	CHF 2600	Submit
Biology biology	4.3	7.3	2012	14.2 Days	CHF 2700	Submit
Insects insects	3.0	5.3	2010	19.7 Days	CHF 2600	Submit
International Journal of Molecular Sciences ijms	5.6	10.0	2000	17.5 Days	CHF 2900	Submit
Marine Drugs marinedrugs	5.7	11.6	2003	14.2 Days	CHF 2900	Submit
Plants plants	4.7	8.5	2012	14.8 Days	CHF 2700	Submit

Preprints.org is a multidisciplinary platform offering a preprint service designed to facilitate the early sharing of your research. It supports and empowers your research journey from the very beginning.

MDPI Topics is collaborating with Preprints.org and has established a direct connection between MDPI journals and the platform. Authors are encouraged to take advantage of this opportunity by posting their preprints at Preprints.org prior to publication:

1. Share your research immediately: disseminate your ideas prior to publication and establish priority for your work.
2. Safeguard your intellectual contribution: Protect your ideas with a time-stamped preprint that serves as proof of your research timeline.
3. Boost visibility and impact: Increase the reach and influence of your research by making it accessible to a global audience.
4. Gain early feedback: Receive valuable input and insights from peers before submitting to a journal.
5. Ensure broad indexing: Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Related Topic

Published Papers (2 papers)

Order results

Content type Publication Date

Result details

Normal Extended Compact

Journals

All Agrochemicals IJMS Insects Marine Drugs Agriculture Plants Agronomy Biology

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

Error

Oops... you haven't selected anything for export.

Ok

clear

attachment

Supplementary material:
Supplementary File 1 (ZIP, 1394 KB)

11 pages, 3395 KB  

Open AccessArticle

Active Secondary Metabolites from Root-Associated Endophytic Fungus Aspergillus tubingensis ZMGR14 and Their Activities Against Plant Pathogenic Fungi

by Haoyue Liu, Hui Jin, Xiaoyan Yang, Zhongxiang Xu, Jinchun Cheng, Lihong Wang, Zuhua Yan and Bo Qin

Biology 2026, 15(10), 812; https://doi.org/10.3390/biology15100812 - 21 May 2026

Viewed by 432

Abstract

This study aimed to separate and characterize compounds from Aspergillus tubingensis ZMGR14. The antifungal activities of monomer compounds and the ethyl acetate (EtOAc) layer from the fermented liquor of A. tubingensis were isolated, purified and structurally identified. The EtOAc layer from the fermented [...] Read more.

This study aimed to separate and characterize compounds from Aspergillus tubingensis ZMGR14. The antifungal activities of monomer compounds and the ethyl acetate (EtOAc) layer from the fermented liquor of A. tubingensis were isolated, purified and structurally identified. The EtOAc layer from the fermented liquor showed significant antifungal activity against Fusarium oxysporum and Alternaria alternata with IC₅₀ values of 273.8 and 330.7 μg·mL⁻¹, respectively. The EtOAc extract was further purified by column chromatography and recrystallization to yield six compounds. Antifungal trials showed that Cyclo-(L-Pro-D-Leu) (5) exhibited the highest inhibition against A. alternata and F. oxysporum, with an IC₅₀ value of 48.1 and 232.7 μM, respectively, and cyclo-(L-Pro-L-Leu) (6) displayed moderate antifungal activity against Alternaria solani, with an IC₅₀ value of 493.4 μM. The results suggest that the EtOAc extract of ZMGR14 and its bioactive compounds hold promise as environmentally friendly microbial fungicides. Full article

(This article belongs to the Topic Research on Natural Bioactive Product-Based Pesticidal Agents—3rd Edition)

►▼ Show Figures

Graphical abstract

attachment

Supplementary material:
Supplementary File 1 (ZIP, 4380 KB)

13 pages, 2171 KB  

Open AccessArticle

Skeletal Stilbenolignan Enantiomers and Flavonoid Derivatives Against Depression in Mice from Dracaena cochinchinensis Exudates

by Tian-Chang He, Fan Fang, Wei-Fen Li, Wen-Jing Yao, Jing-Jing Qi and Yong-Xian Cheng

Int. J. Mol. Sci. 2026, 27(9), 3966; https://doi.org/10.3390/ijms27093966 - 29 Apr 2026

Viewed by 434

Abstract

A pair of enantiomeric stilbene–lignan hybrids, (−)- and (+)-dracaenolignan A (1), and four new flavonoid derivatives, xuejieins F–I (2–5), were isolated from Dracaena cochinchinensis exudates. Compound 1 features an unprecedented carbon skeleton with a 6/6/5/6-fused ring system [...] Read more.

A pair of enantiomeric stilbene–lignan hybrids, (−)- and (+)-dracaenolignan A (1), and four new flavonoid derivatives, xuejieins F–I (2–5), were isolated from Dracaena cochinchinensis exudates. Compound 1 features an unprecedented carbon skeleton with a 6/6/5/6-fused ring system and four consecutive chiral carbons. Their structures were clarified by spectroscopic data, theoretical NMR calculations, and ECD calculations. Furthermore, a potential biogenetic pathway for 1 is put forward. Biological evaluations inspired by the chemical defense of D. cochinchinensis revealed that (−)-1 significantly alleviates LPS-induced neuroinflammation and depression-like behaviors, suggesting potential antidepressant lead structure. Full article

(This article belongs to the Topic Research on Natural Bioactive Product-Based Pesticidal Agents—3rd Edition)

►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

 

Error

Oops... you haven't selected anything for export.

Ok

clear

Displaying articles 1-2