Recent Advances in Veterinary Pharmacology and Toxicology, 2nd Edition

Abstract submission deadline

30 April 2027

Manuscript submission deadline

30 June 2027

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Topic Information

Dear Colleagues,

Nowadays, veterinary pharmacology and toxicology should be regarded as disciplines contributing to the “One Health” paradigm, reducing risk at the animal–human ecosystem level. The use of antimicrobials plays a crucial role in maintaining the safety, health, and rapid development of the animal husbandry industry. In the past 30 years, the fields of veterinary pharmacology and toxicology have experienced rapid development and achieved a series of important results. For example, in 2015, Chinese scientists from the fields of veterinary pharmacology and toxicology first discovered the colistin resistance gene MCR-1. Currently, the development of new veterinary drugs and the rational use of existing antimicrobial drugs are hot topics in this field, and some progress has been made in these areas in recent years. Therefore, we call on scientists in this field to submit their latest research, including but not limited to that on bacterial resistance, combination therapy, drug toxicology and molecular mechanisms, and new drug development. Through this Topic, we hope to attract more scholars to veterinary pharmacology and toxicology and to promote the exchange and development of these disciplines.

Prof. Dr. Chongshan Dai
Prof. Dr. Jichang Li
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	8.2	14.7	2012	18.7 Days	CHF 2900	Submit
Biomolecules biomolecules	5.6	9.3	2011	16.6 Days	CHF 2700	Submit
International Journal of Molecular Sciences ijms	5.6	10.0	2000	17.5 Days	CHF 2900	Submit
Journal of Fungi jof	4.3	8.7	2015	18.2 Days	CHF 2600	Submit
Journal of Xenobiotics jox	4.6	5.1	2011	14.9 Days	CHF 1600	Submit
Metabolites metabolites	4.5	8.1	2011	12.6 Days	CHF 2700	Submit
Toxics toxics	4.9	7.8	2013	17 Days	CHF 2600	Submit
Veterinary Sciences vetsci	2.7	3.9	2014	16.3 Days	CHF 2100	Submit

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Published Papers (4 papers)

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Journals

All IJMS Antioxidants Biomolecules Veterinary Sciences JoX Metabolites Toxics JoF

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Supplementary material:
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17 pages, 8027 KB  

Open AccessArticle

Nanoparticle Vaccine Based on S1 Domain of Porcine Epidemic Diarrhea Virus Elicits Protective Immune Responses in Mice and Pigs

by Pan Tang, Benqiang Li, Enhui Cui, Jie Tao, Jinghua Cheng, Ying Shi, Li Qi, Lilei Lv and Huili Liu

Biomolecules 2026, 16(8), 1090; https://doi.org/10.3390/biom16081090 - 25 Jul 2026

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Abstract

Porcine epidemic diarrhea virus (PEDV) is a major enteric coronavirus that causes severe economic losses to the global swine industry. Current vaccines suffer from weak immunogenicity, insufficient mucosal immunity, and a short duration of protection. Nanoparticle delivery systems have emerged as a promising [...] Read more.

Porcine epidemic diarrhea virus (PEDV) is a major enteric coronavirus that causes severe economic losses to the global swine industry. Current vaccines suffer from weak immunogenicity, insufficient mucosal immunity, and a short duration of protection. Nanoparticle delivery systems have emerged as a promising strategy for next-generation vaccine development. In the present study, we constructed an S1-Ferritin nanoparticle vaccine using the SpyTag-SpyCatcher modular conjugation system. The morphology, particle size, and uniformity of the nanoparticle vaccine were systematically characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). After two immunizations, the S-Ferritin nanoparticle vaccine elicited potent humoral and cellular immune responses in both mice and piglets. In piglets, at 2 weeks post booster vaccination, PEDV-specific serum IgG endpoint titers peaked at 1:2560, virus-neutralizing antibody titers reached 1:256 against the JS-2/2015 strain, and serum IFN-γ levels reached 274 pg/mL. All these immunological indicators were significantly higher than those observed in the PEDV-inactivated whole-virus vaccine group. Furthermore, challenge tests showed that the S1-Ferritin nanoparticle vaccine provided complete protection against PEDV infection and significantly reduced the severity of diarrhea and intestinal damage in piglets after challenge. These findings suggest that the S1-Ferritin nanoparticle vaccine constitutes a promising candidate against PEDV infection, though our study is only a preliminary step and subsequent field trials in pigs are still required. Full article

(This article belongs to the Topic Recent Advances in Veterinary Pharmacology and Toxicology, 2nd Edition)

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36 pages, 2785 KB  

Open AccessReview

Pyrrolizidine Alkaloid-Induced Hepatotoxicity: A Narrative Review on Molecular Mechanisms and Detoxification Strategies

by Yizhuo Fang, Xiaosong Zhang, Chongshan Dai and Zhihui Hao

Antioxidants 2026, 15(5), 635; https://doi.org/10.3390/antiox15050635 - 16 May 2026

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Abstract

Pyrrolizidine alkaloids (PAs), a category of naturally occurring secondary metabolites, are commonly found in various botanical sources. Accumulating evidence indicates that PAs and their biologically active metabolites can interact with cellular components and trigger a variety of toxic effects in animals and humans. [...] Read more.

Pyrrolizidine alkaloids (PAs), a category of naturally occurring secondary metabolites, are commonly found in various botanical sources. Accumulating evidence indicates that PAs and their biologically active metabolites can interact with cellular components and trigger a variety of toxic effects in animals and humans. Notably, PAs exhibit significant hepatotoxic potential via nutritional supplements, environmental dissemination, food chain contamination, and broader ecological pollution. In this review, we summarize PA-induced hepatotoxicity in humans and animals and the underlying molecular mechanisms. It involves oxidative stress, mitochondrial dysfunction, apoptosis, ER stress, inflammation, autophagy, and ferroptosis. Several key signaling pathways, such as nuclear factor-erythroid 2 related factor 2 (Nrf2), mitogen-activated protein kinase (MAPK), protein kinase RNA-like endoplasmic reticulum kinase (PERK), toll like receptor 4 (TLR4), nuclear factor kappa-B (NF-κB), transforming growth factor beta (TGF-β), p53, farnesoid X receptor (FXR), and pregnane X receptor (PXR), are also implicated. Furthermore, this review discusses diagnostic approaches, metabolic activation pathways, and detoxification strategies targeting PA-induced liver injury. Collectively, this review provides a comprehensive understanding of the molecular basis of PA hepatotoxicity and underscores the urgent need for improved risk assessment, early diagnosis, and effective detoxification interventions to mitigate PA-related liver diseases in humans and animals. Full article

(This article belongs to the Topic Recent Advances in Veterinary Pharmacology and Toxicology, 2nd Edition)

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22 pages, 7580 KB  

Open AccessArticle

Zearalenone Promotes Hepatic Stellate Cell Activation and Early Profibrotic Tendency in the Liver

by Lige Bao, Yongze Huang, Jiaxin Bao, Yitong Lu, Chunli Chen, Zhiyong Wu and Jichang Li

Biomolecules 2026, 16(5), 644; https://doi.org/10.3390/biom16050644 - 26 Apr 2026

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Abstract

Zearalenone (ZEA) is a mycotoxin widely present in cereals, feeds, and foods, posing a persistent threat to human and animal health. Hepatic fibrosis is a pathological process characterized by excessive extracellular matrix (ECM) deposition. Chronic liver injury caused by sustained oxidative stress can [...] Read more.

Zearalenone (ZEA) is a mycotoxin widely present in cereals, feeds, and foods, posing a persistent threat to human and animal health. Hepatic fibrosis is a pathological process characterized by excessive extracellular matrix (ECM) deposition. Chronic liver injury caused by sustained oxidative stress can initiate the development of early hepatic fibrosis. However, whether liver injury induced by ZEA can trigger hepatic stellate cell (HSC) activation and promote early profibrotic responses remains unclear. The aim of this study was to assess whether ZEA-induced liver injury promotes HSC activation and early profibrotic responses. To address this, we established a BALB/c mouse exposure model and used the murine HSC line (JS-1) for in vitro validation. The results showed that ZEA exposure caused structural damage in hepatic tissue and produced an incomplete bridging pattern of collagen thickening suggestive of an early profibrotic tendency. ZEA shaped a proinflammatory microenvironment by activating the IκBα/NF-κB axis and induced the TGF-β1/Smad2/3 pathway, accompanied by Smad7 suppression, thereby promoting HSC activation and the expression of fibrosis-related genes. ZEA also altered autophagy-related markers in liver tissue and JS-1 cells. Pharmacological inhibition with chloroquine partially attenuated ZEA-induced upregulation of α-SMA and collagen I/III, suggesting that autophagy-related processes may be involved in ZEA-associated HSC activation and early ECM deposition. In summary, ZEA promotes HSC activation and early profibrotic changes in the liver and is associated with inflammatory activation, TGF-β1/Smad signaling, and altered autophagy-related activity. These findings provide a basis for further investigation into the mechanisms underlying ZEA-induced early profibrotic remodeling in the liver. Full article

(This article belongs to the Topic Recent Advances in Veterinary Pharmacology and Toxicology, 2nd Edition)

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31 pages, 1774 KB  

Open AccessReview

A Narrative Review of Ginkgo Biloba Extract: Biological Function, Molecular Mechanisms, and Applications in Animal Production

by Mengfan Yao, Lu Liu, Zhihui Hao, Jianzhong Shen and Chongshan Dai

Antioxidants 2026, 15(2), 251; https://doi.org/10.3390/antiox15020251 - 14 Feb 2026

Cited by 4 | Viewed by 3180

Abstract

Ginkgo biloba extract (GBE), obtained from dried Ginkgo biloba leaves, provides a natural option. GBE supplementation can increase livestock’s productivity through various biological functions, such as combating oxidative stress, reducing inflammation, optimizing gut microbiota, detoxifying intestinal toxins, and regulating immune responses. In this [...] Read more.

Ginkgo biloba extract (GBE), obtained from dried Ginkgo biloba leaves, provides a natural option. GBE supplementation can increase livestock’s productivity through various biological functions, such as combating oxidative stress, reducing inflammation, optimizing gut microbiota, detoxifying intestinal toxins, and regulating immune responses. In this review, we utilized keywords such as “Ginkgo biloba extract” or “Ginkgo biloba extract” and “animal production” or “animal nutrition” to gather research on its various biological functions and the underlying mechanisms from databases such as Web of Science and PubMed, up to December 2025. Then, we systematically summarize the main bioactive components of GBE, its beneficial effects in livestock at different life stages and during different production cycles, and the related molecular pathways. Additionally, safety assessments and the potential applications were also discussed. This review highlights that GBE may be an effective plant-derived feed additive with multiple functions and strong potential to improve animal health, production efficiency, and product quality under intensive farming conditions. We hope that this review can stimulate broader discussions and better develop and utilize GBE as a feed additive in animal production. Full article

(This article belongs to the Topic Recent Advances in Veterinary Pharmacology and Toxicology, 2nd Edition)

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