Quinoline System in Design and Synthesis of New Bioactive Agents
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 15 September 2026 | Viewed by 642
Special Issue Editor
Special Issue Information
Dear Colleagues,
The quinoline system occupies a special, privileged place in medicinal chemistry. Quinoline derivatives of both natural and synthetic origin exhibit a broad spectrum of biological activity. They possess anticancer, antimalarial, anti-inflammatory, antibacterial, antiviral, antituberculosis, and analgesic properties. Quinoline-based compounds form important scaffolds in medicinal chemistry, primarily used for the design of anti-infective and anticancer drugs. One strategy used in the design of new drugs is the creation of hybrid systems combining two biologically active molecules. This approach can be an alternative to the combined use of two or more drugs, has a beneficial effect on the pharmacokinetic parameters of the compounds (improved bioavailability), and enables their action at the appropriate target site. Research into the synthesis of hybrid systems containing a quinoline structural fragment (8-hydroxyquinoline, 4-aminoquinoline, 4-quinolone system) and other pharmacophoric systems (drug structural fragments, other heterocyclic systems) is of great importance in the design of new biologically active compounds (potential drugs).
This Special Issue of the journal "Molecules", titled "Quinoline System in Design and Synthesis of New Bioactive Agents", is devoted to the following research topics: (1) synthesis and analysis; (2) natural quinoline derivatives; (3) drug design; (4) biological studies; (5) structure-activity relationship (SAR); (6) in silico studies.
Prof. Dr. Andrzej Zięba
Guest Editor
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Keywords
- quinoline derivatives
- synthesis
- analysis
- biological activity
- ADMET
- SAR
- hybrid systems
- pharmacophore substituents
- medicinal chemistry
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