Microfluidic Cell Culture, Monitoring and Analysis (CCMA) Systems
A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".
Deadline for manuscript submissions: closed (20 November 2019) | Viewed by 253
Special Issue Editor
Interests: electric impedance; AC-electrokinetics; dielectrophoresis; electrorotation; lab-on-a-chip (LOC); on-chip sensors; microfluidics; electrothermal micro-pumps
Special Issue Information
Dear Colleagues,
Research on microfluidic cell culture, monitoring and analysis (CCMA) systems is of growing importance in the biological, medical and pharmacological sciences. CCMA systems are based on Lab-on-a-Chip (LOC) and Micro Total Analysis Systems (µTAS) technologies. They can be produced by established manufacturing techniques such as photolithography or a variety of polymer technologies. The systems’ key advantage is the reduced consumption of cells and reagents, while a large number of tests can be performed in parallel with a high analytical throughput. CCMA systems call for the integration of actuators, microreaction techniques and sensors such as micropumps or electrical sensors for physical and chemical parameters, as well as for specific metabolites or gene sequences.
Up to now, many systems have been based on 2D cell cultures, cell monitoring by microscopic techniques and analysis by different types of endpoint assays, such as ELISAs or life-death assays. Only a few commercial systems are available for the online monitoring of such physiologically relevant parameters as acidification, respiration, specific substances such as lactate, as well as changes in the electrical impedance of interdigitated electrode structures to detect the proliferation of adherent cells. The integrative or even purely physical nature of the parameters recorded poses foreseeable problems in converting recorded data in a biologically significant way using systems biology approaches. If physiological cell parameters are recorded during long-term cultivation, the systems can be used to reduce the number of animal experiments in medical diagnostics or drug development (cf. 3R principle: replace, reduce, refine).
This special issue presents research work, brief communications and review articles on new developments in the manufacture and application of microfluidic CCMA systems, with particular interest in biological applications and the advancement of new sensors, microfluidic actuators and approaches to the interpretation of sensor readouts.
Prof. Dr. Jan Gimsa
Guest Editor
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Keywords
- Lab-on-a-chip (LOC)
- Micro Total Analysis Systems (µTAS)
- Microfluidic MEMS
- 3R principle
- Absorption, distribution, metabolism, and excretion (ADME)
- On-chip sensors
- pH sensors
- Oxygen sensors
- IDES
- Systems biology
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