The Role of Dietary Antioxidants in Alleviating Oxidative Stress and Inflammation for Enhanced Immunity in Animals

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 July 2026 | Viewed by 664

Special Issue Editors


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Guest Editor
Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Interests: natural antioxidants; synthetic drugs; antioxidant compounds; cellular protective mechanism; cellular functionality; oxidative stress; ROS/RNS; lipid peroxidation; inflammation; ROS/RNS metabolisms; fibrosis; preterm pregnancy; neurodegenerative disease; cancer
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Guest Editor
College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
Interests: nutrition and metabolism (amino acids); oxidative stress and redox biology; gut microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Antioxidants, "The Role of Dietary Antioxidants in Alleviating Oxidative Stress and Inflammation for Enhanced Immunity in Animals”, aims to provide a comprehensive, multidisciplinary overview of the current knowledge in this field.

Over the past 10 years, more and more studies have established the application of dietary antioxidants and their biological actions to eliminate damage from reactive oxygen species (ROS; superoxide (●O2), hydrogen peroxide (H2O2), hydroxyl (●OH) radicals)), reactive nitrogen species (RNS; nitric oxide (●NO)), and oxidative stress, which are associated with the development of subclinical diseases and depressed indicators in farm animals (cows, sheep, goats, swine, pigs, hens, chickens). The application of natural and synthetic (additive) antioxidants (polyphenols, flavonoids, vitamins, trace elements, fatty acids and phytonutrients, etc.; insect meals) as additives in feed, supplements, and foods presents farmers, producers and animal researchers with hope to improve productivity and the quality of animal products (meat, dairy products, eggs). The accumulation of dietary antioxidants in the body tissues and gastrointestinal tract of farm animals can improve the quality and shelf life of meat, milk, and eggs by fully regulating the body's redox homeostasis.
Therefore, a complete understanding of the ways to eliminate radical imbalance and oxidative changes through antioxidant diets in cases of nutritional deficiencies; climate change (drought); parasitic infestation; or animal species genetics, sex, age, etc., can be applied to enhance the health of animals, the quality of their products, and, consequently, human health.

Original scientific articles, short reports, hypotheses, and literature reviews describing the role of antioxidant dietary nutrition in neutralizing free radicals, remedying oxidative-induced disorders, and directly monitoring biological markers will be considered. We encourage the submission of scientific and clinical studies that will contribute to the progress of this complex field and allow us to outline future directions for work.

Potential topics could include the following: antioxidant defense; dietary intervention; bioactive compounds; feeding activities;  prooxidants; stress factors, redox balance; oxidation; ROS/RNS; livestock production; meat, milk and egg quality; health and well-being.

Dr. Yanka D. Karamalakova
Prof. Dr. Jie Yin
Guest Editors

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Keywords

  • antioxidants
  • antioxidant feeding
  • insect meal
  • growth performance
  • digestible energy
  • nutrient digestibility
  • blood biochemistry
  • oxidative stress (OS)
  • lipid peroxidation (MDA)
  • ROS/RNS
  • superoxide dismutase (SOD)
  • catalase (CAT)
  • glutathione (GSH)
  • glutathione peroxidase (GPx)
  • inflammation markers
  • total antioxidant capacity (TAC)
  • meat, milk, eggs quality

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Published Papers (1 paper)

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Research

23 pages, 3627 KB  
Article
Probiotic Combination of Lactiplantibacillus plantarum M1 and Limosilactobacillus reuteri K4 Alleviates Early Weaning-Induced Intestinal Injury in Lambs via Modulation of Oxidative and Inflammatory Pathways
by Qicheng Lu, Peng Zhang, Yujie Niu, Chuying Wang, Fengshuo Zhang, Junli Niu, Weibin Zeng, Cheng Chen and Wenju Zhang
Antioxidants 2026, 15(1), 132; https://doi.org/10.3390/antiox15010132 - 20 Jan 2026
Viewed by 265
Abstract
Early weaning in intensive lamb production improves reproductive efficiency but predisposes lambs to diarrhea, oxidative stress, and intestinal barrier dysfunction, highlighting the need for non-antibiotic strategies to protect gut health. This study evaluated whether a sheep-derived mixed probiotic could alleviate early weaning–induced intestinal [...] Read more.
Early weaning in intensive lamb production improves reproductive efficiency but predisposes lambs to diarrhea, oxidative stress, and intestinal barrier dysfunction, highlighting the need for non-antibiotic strategies to protect gut health. This study evaluated whether a sheep-derived mixed probiotic could alleviate early weaning–induced intestinal injury and clarified its potential molecular mechanisms. Early weaning reduced body weight, average daily gain and feed efficiency, increased diarrhea, decreased plasma and colonic catalase (CAT), glutathione peroxidase (GSH-PX), and superoxide dismutase (SOD) activities, increased malondialdehyde (MDA), elevated interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), reduced interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), increased plasma and mucosal immunoglobulin A, M, and G (IgA, IgM, IgG), and increased colonic lipopolysaccharide (LPS) with reduced diamine oxidase (DAO). Intestinally, EW induced villus atrophy, deeper crypts, lower villus height-to-crypt depth ratios, goblet cell loss, higher histopathological scores, and decreased colonic mucin 2, zonula occludens-1, claudin-1, and occludin. Probiotic supplementation partially reversed these alterations, restoring antioxidant enzyme activities, improving villus architecture and barrier protein expression, and rebalancing cytokine and immunoglobulin profiles. Transcriptomic and network analyses showed that early weaning activated Cytokine–cytokine receptor, NF-κB, TNF and Th17 pathways, whereas probiotics suppressed a weaning-responsive inflammatory gene module, downregulated key hub genes, and enhanced peroxisome proliferator-activated receptor (PPAR) signaling. These results show that supplementing early-weaned lambs with a mixed probiotic generated from sheep is an efficient nutritional strategy to reduce intestinal oxidative and inflammatory damage associated with weaning and to enhance their health and performance. Full article
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