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Nutritional and Health Value of Natural Products From Medicinal Plants on Human Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 July 2025) | Viewed by 674

Special Issue Editor

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Interests: gut microbiota; application and research and development of traditional Chinese medicine in the disease prevention and control of human and animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products (NPs) isolated from medicinal plants, such as polysaccharides, flavonoids, saponins, alkaloids, and others, are widely used to treat human diseases or maintain health. NPs are regarded as therapeutic agents, functional additives, or health products, as they may serve as drug candidates, lead compounds for drug design, or foods. Plant-derived therapeutics have several advantages, such as wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Numerous studies have reported the efficacy of NPs from medicinal plants in ameliorating several human diseases, such as cancers, inflammation, fibrosis, cardiovascular, and infections. Moreover, many in vitro and in vivo studies have exposed the multiple molecular mechanisms of NPs’ pharmacological benefits. The submission of studies on the treatment effects and mechanisms of extracts from medicinal plants on humans will be welcome.

The purpose of this Special Issue is to collect original research articles, short communications, and reviews containing new perspectives and discoveries of the functional and pharmacological effects of natural products, including the molecular mechanisms and therapeutic effects of natural products in human epidemiological studies and new insights towards the role of natural products in maintaining and promoting human health, with the ultimate aim of improving health outcomes for patients worldwide. For this upcoming Nutrients Special Issue, we also recommend that submissions include placebo-controlled clinical studies of medicinal plant extracts, biochemical characterization, and potency assessments using scientifically analytical methods.

Dr. Yi Wu
Guest Editor

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Keywords

  • natural products and extracts
  • medicinal and food plants
  • biological activities
  • human health
  • molecular mechanisms

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Published Papers (1 paper)

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Research

14 pages, 1303 KB  
Article
Non-Targeted Metabolomic Analysis of Ethanol Extract of Propolis and Its Anti-Inflammatory Effects in LPS-Induced BV2 Microglial Cells via the TLR4 Signaling Pathway
by Xiaolan Xu, Chunxia Li, Yuxuan Zhu, Shuangshuang Zhao, Fangjing Wu, Qian He, Lizhen Wei, Xinle Duan and Jianghong Li
Nutrients 2025, 17(17), 2831; https://doi.org/10.3390/nu17172831 - 30 Aug 2025
Viewed by 158
Abstract
Propolis contains abundant flavonoid and phenolic compounds, whose composition and concentration vary significantly in different geographical origins, thereby affecting its bioactive properties including anti-inflammatory, antioxidant, and antimicrobial activities. In this study, the flavonoid and phenolic content in the ethanol extract of propolis (EEP) [...] Read more.
Propolis contains abundant flavonoid and phenolic compounds, whose composition and concentration vary significantly in different geographical origins, thereby affecting its bioactive properties including anti-inflammatory, antioxidant, and antimicrobial activities. In this study, the flavonoid and phenolic content in the ethanol extract of propolis (EEP) from Henan (HN) and Shandong (SD) provinces was quantitatively analyzed, and the results showed that concentrations of both bioactive components in HN were slightly higher than those in SD. The non-targeted metabolomics technology was further employed to analyze the components of EEP, and a total of 10683 metabolites were detected. In the comparison between the samples of HN and SD, there were a total of 1436 differential metabolites, with 553 decreased and 883 increased in the HN sample. Among them, there were 205 differential metabolites related to flavonoids and phenols, with 108 decreased and 97 increased in the HN sample. However, a greater number of carboxylic acids and derivatives, fatty derivatives and organooxygen metabolites were found at higher relative levels in the HN sample. As a result, the EEP of the HN sample was selected to investigate its inhibitory effect on inflammation in lipopolysaccharide (LPS)-induced BV2 microglia cells. The results showed that LPS promoted the M1 polarization of BV2 microglia. However, treatment with EEP at concentrations of 10 µg/mL, 5 µg/mL, and 2.5 µg/mL could partially restore the cell morphology to its non-activated state. Meanwhile, LPS stimulation increased the protein levels of IL-1β, IL-6 and TNF-α significantly, as well as the relative gene expression levels of IL-1β, IL-6, TNF-α, COX-2, iNOS and TLR4. After treatment with the EEP, the expression levels of these three proteins and six genes were significantly decreased. These findings revealed that EEP effectively inhibited the M1 polarization of LPS-induced BV2 cells and decreased the expression of inflammatory factors, indicating its potential as a therapeutic agent for neuroinflammation. Full article
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