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Life
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Antimicrobial Innovations
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Antimicrobial Innovations

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: 15 July 2026 | Viewed by 5407

Special Issue Editors

Dr. Pere Puigbò

E-Mail Website
Guest Editor
Department of Animal and Food Science, Autonomous University of Barcelona, 08193 Cerdanyola del Vallès, Spain
Interests: biology; evolution; microbial genomics; computational biology
Special Issues, Collections and Topics in MDPI journals
Dr. Miho Nakamura

E-Mail Website
Guest Editor
Medicity Research Laboratory, University of Turku, 20014 Turku, Finland
Interests: biomedicine; cell biology; biomaterials

Special Issue Information

Dear Colleagues,

Antimicrobial innovations include the development and application of new strategies, compounds, and technologies to prevent and control the growth of harmful microorganisms. With the rise of antimicrobial resistance, these innovations are essential to protect people’s health, extend products’ shelf life, and reduce reliance on traditional antibiotics. This Special Issue welcomes articles proposing antimicrobial innovations including biopreservatives, plant-based extracts, peptides, nanomaterials, and bacteriophages, each offering unique benefits in combating microbial threats and the spread of antimicrobial resistance. Topics of interest may include, but are not limited to, innovations enhancing safety and quality through novel biopreservation techniques, delivery systems, and advanced biomaterials.

Dr. Pere Puigbò
Dr. Miho Nakamura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • biopreservation
  • lactic acid bacteria
  • bacteriocins
  • bacteriophages
  • natural antimicrobials
  • antimicrobial peptides
  • foodborne pathogens
  • antimicrobial biomaterials
  • race for the surface
  • microbial growth models
  • food safety

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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12 pages, 276 KB  
Article
Predominance of Gram-Negative Pathogens and Treatment Complexity in Peritoneal Dialysis-Associated Peritonitis: A Single-Center Experience
by Daniela Marinescu, Laurențiu Augustus Barbu, Tiberiu-Ștefăniță Țenea-Cojan, Daniela-Teodora Maria, Sorin-Ioan Zaharie, Răzvan Alexandru Marinescu, Valeriu Șurlin, Ana-Maria Ciurea and Anca-Elena Duduveche
Life 2026, 16(4), 558; https://doi.org/10.3390/life16040558 - 29 Mar 2026
Viewed by 279
Abstract
Background: Peritoneal dialysis-associated peritonitis (PDAP) remains a major complication of peritoneal dialysis and an important cause of technique failure. Increasing evidence suggests marked inter-center variability in PDAP microbiology, with a growing contribution of Gram-negative pathogens in some settings. Methods: We performed a single-center, [...] Read more.
Background: Peritoneal dialysis-associated peritonitis (PDAP) remains a major complication of peritoneal dialysis and an important cause of technique failure. Increasing evidence suggests marked inter-center variability in PDAP microbiology, with a growing contribution of Gram-negative pathogens in some settings. Methods: We performed a single-center, retrospective observational study of adult peritoneal dialysis patients with PDAP treated between January 2020 and December 2024. Episodes were defined according to International Society for Peritoneal Dialysis criteria. Clinical, microbiological, and antimicrobial treatment data were analyzed, with particular focus on relapsing peritonitis and treatment complexity. Results: Thirty-three patients were included (median age 59 years; 51.5% male). Gram-negative organisms were the most frequent causative agents (48.5%), followed by Gram-positive bacteria (21.2%), fungal pathogens (6.1%), and culture-negative episodes (6.1%). Relapsing or recurrent peritonitis occurred in 12.1% of cases and was significantly associated with increased antimicrobial treatment complexity, with all relapsing episodes requiring three or more antimicrobial agents (p = 0.02). Conclusions: Gram-negative pathogens predominated in this single-center PDAP cohort and showed trends toward greater antimicrobial treatment complexity and a higher burden of relapsing episodes; however, these findings should be interpreted cautiously due to the limited sample size and lack of statistical significance. These findings nevertheless support the need for center-specific microbiological surveillance and individualized management strategies in peritoneal dialysis-associated peritonitis. Full article
(This article belongs to the Special Issue Antimicrobial Innovations)

Review

Jump to: Research

15 pages, 1153 KB  
Review
Use of Live Biopreservatives and Bacteriophages to Enhance the Safety of Meat Products
by Cristina Rodríguez-Marca, Cristina Domenech-Coca, Miho Nakamura, Nàdia Ortega-Olivé and Pere Puigbò
Life 2025, 15(2), 197; https://doi.org/10.3390/life15020197 - 28 Jan 2025
Cited by 6 | Viewed by 4403
Abstract
Critical health considerations for both raw and processed meats include addressing bacterial spoilage and ensuring safety. Nitrites and nitrates are widely used in the meat industry to enhance color and flavor and extend shelf life. However, health concerns linked to their use make [...] Read more.
Critical health considerations for both raw and processed meats include addressing bacterial spoilage and ensuring safety. Nitrites and nitrates are widely used in the meat industry to enhance color and flavor and extend shelf life. However, health concerns linked to their use make reducing nitrites and nitrates in meat production a significant challenge with potential benefits for both the food industry and consumer health. This challenge has been addressed with the use of biopreservatives, i.e., substances extracted from natural sources or produced by fermentation that can enhance food quality and safety. In this article, we assess the use of live biopreservatives (LBs), defined here as microorganisms that produce antimicrobial substances that can be used to preserve and extend the shelf life of food. Moreover, the potential synergistic effects of LBs with bacteriophages and biodegradable food packaging for meat is also explored. This innovative combination offers a comprehensive approach to meat preservation, enhancing both microbial control and sustainability. Overall, the inclusion of LBs extends the shelf life of meat products through bacteriostatic mechanisms, whereas bacteriophages offer direct (lytic) action against pathogens. Enhancing meat preservation and safety with mixed microbe-mediated strategies requires deeper empirical and theoretical insights and further revision of laws and ethical considerations. Full article
(This article belongs to the Special Issue Antimicrobial Innovations)
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