Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 March 2026) | Viewed by 31650
Special Issue Editor
Interests: gut-brain axis; neuroimmune disease; GI-associated plasmacytoid dendritic cells; Alzheimer’s disease; myalgic encephalomyelitis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue, “Advances of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness of unknown etiology, characterized by multiple physical symptoms and comorbid conditions. Symptoms often reported by those with ME/CFS include unexplained fatigue that lasts for more than six months, post-exertional malaise, neurocognitive problems, unrefreshing sleep, and gastrointestinal issues. Clinical laboratory findings often include inflammatory sequelae, metabolic disturbances, self-reactive antibodies, and immune cell abnormalities. Although many who suffer from ME/CFS report that they developed the condition following a “flu-like” illness from which they never fully recovered, an etiological agent has not been reproducibly identified. Likewise, many individuals infected by the SARS-CoV-2 virus often never fully recover and present with symptoms that significantly overlap with those of ME/CFS. This syndrome is typically referred to as long COVID-19 or post-acute sequelae of SARS COV-2 infection. In this Special Issue, which addresses the advances in research regarding myalgic encephalomyelitis/chronic fatigue syndrome, we aim to publish original research papers and reviews that focus on the involvement of the immune system in ME/CFS. Reports that leverage commonalities between ME/CFS and long COVID-19 to identify the mechanisms behind immune abnormalities are highly encouraged.
Dr. Vincent C. Lombardi
Guest Editor
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Keywords
- ME/CFS
- PASC
- long COVID-19
- inflammation
- innate immunity
- adaptive immunity
- mast cell activation
- post-infection syndrome
- metabolism
- autoantibodies
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