Search Results (188)

Molecular sensor systems, e.g., implantables and wearables, provide extensive health-related monitoring. Glucose sensor systems have historically prevailed in wearable bioanalysis applications due to their continuous and reliable glucose monitoring, a feat not yet accomplished for other biomarkers. However, the advancement of reagentless detection methodologies may facilitate the creation of molecular sensor systems for multiple analytes. Improving the sensitivity and selectivity of molecular sensor systems is also crucial for biomarker detection under intricate physiological circumstances. The term multidomain molecular sensor systems is utilized to refer, in general, to both biological and chemical sensor systems. This review examines methodologies for enhancing signal amplification, improving selectivity, and facilitating reagentless detection in multidomain molecular sensor devices. The review also analyzes the fundamental components of multidomain molecular sensor systems, including substrate materials, bodily fluids, power, and decision-making units. The review article further investigates how extensive data gathered from multidomain molecular sensor systems, in conjunction with current data processing algorithms, facilitate biomarker detection for precision medicine. Full article

Chronic Coronary Syndrome (CCS) significantly impacts quality of life and increases the risk of adverse cardiovascular events, remaining the leading cause of mortality worldwide. The use of sensor technology in medicine is emerging as a promising approach to enhance the management and monitoring of patients across a wide range of diseases. Recent advancements in engineering and nanotechnology have enabled the development of ultra-small devices capable of collecting data on critical physiological parameters. Several sensors integrated in wearable and implantable devices, instruments for exhaled gas analysis, smart stents and tools capable of real time biochemical analysis have been developed, and some of them have demonstrated to be effective in CCS management. Their application in CCS could provide valuable insights into disease progression, ischemic events, and patient responses to therapy. Moreover, sensor technologies can support the personalization of treatment plans, enable early detection of disease exacerbations, and facilitate prompt interventions, potentially reducing the need for frequent hospital visits and unnecessary invasive diagnostic procedures such as coronary angiography. This review explores sensor integration in CCS care, highlighting technological advances, clinical potential, and implementation challenges. Full article

This study analyzes the recent scientific literature on advanced biocompatible materials for triboelectric nanogenerators (TENGs) in biomedical applications. Focusing on materials like synthetic polymers, carbon-based derivatives, and advanced hybrids, the study interprets findings regarding their triboelectric properties and performance influenced by surface texture and additive manufacturing techniques. Major findings reveal that precise control over surface morphology, enabled by additive manufacturing (AM) is promising for optimizing transferred charge density and maximizing TENG efficiency. The analysis highlights the relevance of these material systems and fabrication strategies for developing self-powered wearable and implantable biomedical devices through enabling biocompatible energy-harvesting components that can operate autonomously without external power, underscoring the need for stringent biocompatibility and performance stability. This work synthesizes current progress, identifying critical material and process design parameters for advancing the field of biocompatible TENGs. Full article

Silk fibroin (SF)-based intelligent wearable systems represent a frontier research direction in artificial intelligence and precision medicine. Their core efficacy stems from the inherent advantages of silk fibroin, including excellent mechanical properties, interfacial compatibility, and tunable structure. This article systematically reviews conductive modification strategies for silk fibroin and its research progress in the smart wearable field. It elaborates on the molecular structural basis of silk fibroin for use in smart wearable devices, critically analyzes five conductive functionalization strategies, compares the advantages, disadvantages, and applicable domains of different modification approaches, and summarizes research achievements in areas such as bioelectrical signal sensing, energy conversion and harvesting, and flexible energy storage. Concurrently, an assessment was conducted focusing on the priority performance characteristics of the materials across diverse application scenarios. Specific emphasis was placed on addressing the long-term functional performance (temporal efficacy) and degradation stability of silk fibroin-based conductive materials exhibiting high biocompatibility in implantable settings. Additionally, the compatibility issues arising between externally applied coatings and the native substrate matrix during conductive modification processes were critically examined. The article also identifies challenges that silk fibroin-based smart wearable devices currently face and suggests potential future development directions, providing theoretical guidance and a technical framework for the functional integration and performance optimization of silk fibroin-based smart wearable devices. Full article

The healthcare industry is witnessing a rapid rise in the adoption of wearable and implantable medical devices, including advanced electrochemical sensors and other smart diagnostic technologies. These devices are increasingly used to enable real-time monitoring of physiological parameters, allowing for faster diagnosis and more personalized care plans. Their growing presence reflects a broader shift toward smart connected healthcare systems aimed at delivering immediate and actionable insights to both patients and medical professionals. At the same time, the healthcare industry is increasingly targeted by cyberattacks, primarily due to the high value of medical information; in addition, the growing integration of ICT technologies into medical devices has introduced new vulnerabilities that were previously absent in this sector. To mitigate these risks, new international guidelines advocate the adoption of best practices for secure software development, emphasizing a security-by-design approach in the design and implementation of such devices. However, the vast and fragmented nature of the information required to effectively support these development processes poses a challenge for the numerous stakeholders involved. In this paper, we demonstrate how key features of the Malware Information Sharing Platform (MISP) can be leveraged to systematically collect and structure vulnerability-related information for medical devices. We propose tailored structures, objects, and taxonomies specific to medical devices, facilitating a standardized data representation that enhances the security-by-design development of these devices. Full article

We report two cases of prolonged “unexpected” asystoles in patients with a wearable cardioverter-defibrillator (WCD) and a subcutaneous implantable cardioverter-defibrillator (ICD), respectively, which were promptly recognized and successfully managed. As these devices are designed to recognize and treat malignant tachyarrhythmias but do not provide pacing capabilities, it is crucial to identify patients with paroxysmal conduction disorders who might require backup pacing. For this reason, it is also important to leverage the monitoring features of both devices and their ability to detect the occurrence of bradyarrhythmias. Full article

Stretchable display technology has rapidly evolved, enabling a new generation of flexible electronics with applications ranging from wearable healthcare and smart textiles to implantable biomedical devices and soft robotics. This review systematically presents recent advances in stretchable displays, focusing on intrinsic stretchable materials, wavy surface engineering, and hybrid integration strategies. The paper highlights critical breakthroughs in device architectures, energy-autonomous systems, durable encapsulation techniques, and the integration of artificial intelligence, which collectively address challenges in mechanical reliability, optical performance, and operational sustainability. Particular emphasis is placed on the development of high-resolution displays that maintain brightness and color fidelity under mechanical strain, and energy harvesting systems that facilitate self-powered operation. Durable encapsulation methods ensuring long-term stability against environmental factors such as moisture and oxygen are also examined. The fusion of stretchable electronics with AI offers transformative opportunities for intelligent sensing and adaptive human–machine interfaces. Despite significant progress, issues related to large-scale manufacturing, device miniaturization, and the trade-offs between stretchability and device performance remain. This review concludes by discussing future research directions aimed at overcoming these challenges and advancing multifunctional, robust, and scalable stretchable display systems poised to revolutionize flexible electronics applications. Full article

The parameters of electromagnetic emissions from the antenna of a wearable radio communication module (parameterizing device functionality) were investigated at different positions near the body where an antenna is located. The specific absorption rate (SAR) coefficient was also investigated as a way of parameterizing the absorption of electromagnetic radiation in the user’s body adjacent to the antenna in various locations. The modeled exposure scenarios concerned a body-worn device with a 2.45 GHz ISM band antenna (used, e.g., for Wi-Fi 2G/Bluetooth applications). The antennas were modeled as follows: (1) located directly on the body (considered to be a model of a disposable, adhesive device) or (2) next to the body (considered to be a model of a classic, reusable, wearable electronic device located inside a plastic housing). Several body sections adjacent to the antenna were considered: head, arm, forearm, and chest (simplified and anatomical body models were used). The numerical models of the exposure scenarios were verified by relevant laboratory tests using physical models. It was found that the use of simplified models of the human body (numerical or physical) may be sufficient when analyzing antenna performance and SAR in a user’s body, such as in studies regarding microwave imaging and sensing, wireless implantable devices, wireless body-area networks or SAR estimation. Full article

Bioelectronics for wearable and implantable biomedical devices has attracted significant attention due to its potential for continuous health monitoring, early disease diagnosis, and real-time therapeutic interventions. Among the various materials explored for bioelectronic applications, hydrogels derived from natural biopolymers have emerged as highly promising candidates, owing to their inherent biocompatibility, mechanical compliance akin to biological tissues, and tunable structural properties. This review provides a comprehensive overview of recent advancements in the design and application of protein-based hydrogels, including gelatin, collagen, silk fibroin, and gluten, as well as carbohydrate-based hydrogels such as chitosan, cellulose, alginate, and starch. Particular emphasis is placed on elucidating their intrinsic material characteristics, modification strategies to improve electrical and mechanical performance, and their applicability for bioelectronic interfaces. The review further explores their diverse applications in physiological and biochemical signal sensing, bioelectric signal recording, and electrical stimulation. Finally, current challenges and future perspectives are discussed to guide the ongoing innovation of hydrogel-based systems for next-generation bioelectronic technologies. Full article

The rapid development of wearable electronics requires multifunctional, transient electronic devices to reduce the ecological footprint and ensure data security. Unfortunately, existing transient electronic materials need to be degraded in chemical solvents or body fluids. Here, we report green luminescent, water-soluble, and biocompatible piezoelectric nanofibers developed by electrospinning green carbon quantum dots (G-CQDs), mulberry silk fibroin (SF), and polyvinyl alcohol (PVA). The introduction of G-CQDs significantly enhances the piezoelectric output of silk fibroin-based fiber materials. Meanwhile, the silk fibroin-based hybrid fibers maintain the photoluminescent response of G-CQDs without sacrificing valuable biocompatibility. Notably, the piezoelectric output of a G-CQD/PVA/SF fiber-based nanogenerator is more than three times higher than that of a PVA/SF fiber-based nanogenerator. This is one of the highest levels of state-of-the-art piezoelectric devices based on biological organic materials. As a proof of concept, in the actual scenario of a rope skipping exercise, the G-CQD/PVA/SF fiber-based nanogenerator is further employed as a self-powered wearable sensor for real-time sensing of athletic motions. It demonstrates high portability, good flexibility, and stable piezoresponse for smart sports applications. This class of water-disposable, piezo/photoactive biological materials could be compelling building blocks for applications in a new generation of versatile, transient, wearable/implantable devices. Full article

Ultra-reliable low-latency communication (URLLC) is a cornerstone of beyond 5G and future 6G networks, particularly for mission-critical applications such as the healthcare Internet of Things. In applications such as remote surgery, emergency services, and real-time health monitoring, it is imperative to ensure stringent latency and reliability requirements. However, the energy constraints of wearable and implantable medical devices pose stringent challenges to conventional URLLC methods. This paper proposes an energy-aware URLLC framework that dynamically prioritizes healthcare traffic to optimize transmission energy and reliability. The framework integrates a priority-aware packet scheduler, adaptive transmission control, and edge-enabled reliability management. Extensive Monte Carlo simulations are carried out on various network loads and varying edge computing delays to evaluate performance metrics, like latency, throughput, reliability score, energy consumption, delay violation rate, and Jain’s fairness index. Results illustrate that the suggested technique achieves lower latency, energy consumption, and delay violation rates and higher throughput and reliability scores, sacrificing Jain’s fairness index graciously at peak network overload. This study is a potential research lead for green URLLC in healthcare IoT systems to come. Full article

This work presents a current-controlled CMOS ring oscillator (CCRO) optimized for ultra-low-voltage applications in next-generation energy-constrained systems. Leveraging bulk voltage tuning in 22 nm FDSOI differential inverter stages, the topology enables frequency adjustment while operating MOSFETs in the subthreshold region—critical for minimizing power in sub-1 V environments. Simulations at 0.4 V supply demonstrate robust performance: a three-stage oscillator achieves a 537–800 MHz tuning range with bias current (I_BIAS) modulation from 30–130 nA, while a four-stage configuration spans 388–587 MHz. At 70 nA I_BIAS, the three-stage design delivers a nominal frequency of 666.8 MHz with just 10.23 µW power dissipation, underscoring its suitability for ultra-low-power IoT and biomedical applications. The oscillator’s linear frequency sensitivity (2.63 MHz/nA) allows precise, dynamic control over performance–power tradeoffs. To address diverse application needs, the design integrates three tunability mechanisms: programmable capacitor arrays for coarse frequency adjustments, configurable stage counts (three- or four-stage topologies), and supply voltage scaling. This multi-modal approach extends the operational range to 1 MHz–1 GHz, ensuring compatibility with low-speed sensor interfaces and high-speed edge-computing tasks. The CCRO’s subthreshold operation at 0.4 V—coupled with nanoampere-level current consumption—makes it uniquely suited for battery-less systems, wearable health monitors, and implantable medical devices where energy efficiency and adaptive clocking are paramount. By eliminating traditional voltage-controlled oscillators’ complexity, this topology offers a compact, scalable solution for emerging ultra-low-power technologies. Full article

Electroactive polymers (EAPs) have emerged as versatile materials for self-powered actuators and biosensors, revolutionizing biomedical diagnostics and healthcare technologies. These materials harness various energy harvesting mechanisms, including piezoelectricity, triboelectricity, and ionic conductivity, to enable real-time, energy-efficient, and autonomous sensing and actuation without external power sources. This review explores recent advancements in EAP-based self-powered systems, focusing on their applications in biosensing, soft robotics, and biomedical actuation. The integration of nanomaterials, flexible electronics, and wireless communication technologies has significantly enhanced their sensitivity, durability, and multifunctionality, making them ideal for next-generation wearable and implantable medical devices. Additionally, this review discusses key challenges, including material stability, biocompatibility, and optimization strategies for enhanced performance. Future perspectives on the clinical translation of EAP-based actuators and biosensors are also highlighted, emphasizing their potential to transform smart healthcare and bioelectronic applications. Full article

The currently used electrical energy devices for portable applications are in limited life and need of frequent recharging, it is a big bottleneck for wireless and transportation systems. The scientific community is motivated to find innovative and efficient devices to convert environmental energy into useful forms. Nanogenerator can mitigate this issue by harvesting ambient energy of different forms into useful electrical energy. Particularly flexible nanogenerators can efficiently convert ambient mechanical energy into electrical energy which can be fruitfully used for self-powered sensors and electronic appliances. Zinc oxide is an interesting photosensitive and piezoelectric material that is expected to play a vital role in the synergetic harvesting of environmental thermal, sound, mechanical, and solar energies. As ZnO can be synthesized using easy methods and materials at low cost, the conversion efficiencies of solar and other energy forms can increase considerably. ZnO is a versatile material with interesting semiconducting, optical, and piezoelectric properties; it can be used advantageously to harvest more than one type of ambient energy. The coupled semiconducting and piezoelectric properties of ZnO are attractive for fabricating nanogenerators capable of harvesting both ambient optical and mechanical energies simultaneously. These nanolevel conversion devices are much required to power remote and implantable devices without the need for additional power sources. The present review briefly discusses the principles and mechanisms of different energy harvesting abilities of ZnO nanorods and their composites by consolidating available literature. In addition, the developments taking place in nanogenerators of different kinds—such as photovoltaic, piezoelectric, pyroelectric, and triboelectrics for self-powered technology—and their progress in hybrid energy harvesting application is reviewed. Full article

Orthopedics is undergoing a transformative shift driven by personalized medical technologies that enhance precision, efficiency, and patient outcomes. Virtual surgical planning, robotic assistance, and real-time 3D navigation have revolutionized procedures like total knee arthroplasty and hip replacement, offering unparalleled accuracy and reducing recovery times. Integrating artificial intelligence, advanced imaging, and 3D-printed patient-specific implants further elevates surgical precision, minimizes intraoperative complications, and supports individualized care. In sports orthopedics, wearable sensors and motion analysis technologies are revolutionizing diagnostics, injury prevention, and rehabilitation, enabling real-time decision-making and improved patient safety. Health-tracking devices are advancing recovery and supporting preventative care, transforming athletic performance management. Concurrently, breakthroughs in biologics, biomaterials, and bioprinting are reshaping treatments for cartilage defects, ligament injuries, osteoporosis, and meniscal damage. These innovations are poised to establish new benchmarks for regenerative medicine in orthopedics. By combining cutting-edge technologies with interdisciplinary collaboration, the field is redefining surgical standards, optimizing patient care, and paving the way for a highly personalized and efficient future. Full article