Search Results (4,890)

Floods are considered one of the most devastating natural hazards, frequently resulting in substantial loss of lives and widespread damage to infrastructure. In the period of 4–7 September 2023, the region of Thessaly experienced unprecedented rainfall rates due to Storm Daniel, which caused significant flooding and many damages and fatalities. The southeastern areas of Trikala were among the many areas of Thessaly that suffered the effects of these rainfalls. In this research, a flood susceptibility assessment (FSA) of the broader area surrounding the settlement of Megala Kalyvia is carried out through the analytical hierarchy process (AHP) as a multicriteria analysis method, using Geographic Information Systems (GIS). The purpose of this study is to evaluate the prolonged flood susceptibility indicated within the area due to the past floods of 2018, 2020, and 2023. To determine the flood-prone areas, seven factors were used to determine the influence of flood susceptibility, namely distance from rivers and channels, drainage density, distance from confluences of rivers or channels, distance from intersections between channels and roads, land use–land cover, slope, and elevation. The flood susceptibility was classified as very high and high across most parts of the study area. Finally, a comparison was made between the modeled flood susceptibility and the maximum extent of past flood events, focusing on that of 2023. The results confirmed the effectiveness of the flood susceptibility assessment map and highlighted the need to adapt to the changing climate patterns observed in September 2023. Full article

Background/Objectives: The quality of surgical margins has been shown to be a prognostic factor in many sarcoma entities, yet its role in osteosarcoma remains controversial. While previous studies have shown that the outcome was not related to the margin width in bone, the impact of the extraosseous margin width (margin at the soft tissue invasion)—which needs to be close sometimes due to neurovascular structures—needs to be assessed. This study aims to evaluate the influence of soft tissue surgical margins on local recurrence and overall survival in patients with high-grade osteosarcoma. Methods: We conducted a retrospective, single-center study including 75 patients treated for high-grade osteosarcoma. All patients underwent standardized neoadjuvant chemotherapy followed by complete surgical resection. Patients were stratified into three groups based on the histological margin width of the extraosseous parts: group 1 (<1 mm), group 2 (1–5 mm), and group 3 (≥5 mm). Primary endpoints were local recurrence and overall survival (OS), analyzed using Kaplan–Meier estimates, log-rank tests, and Cox regression. Results: Local recurrence occurred in seven patients (9%). Although the overall comparison between the three groups was not statistically significant (p = 0.074), a subgroup analysis revealed a significantly higher recurrence rate in patients with margins < 1 mm compared to those with wider margins (p = 0.024). No significant differences in overall survival (OS) were observed between the groups (p = 0.896). Tumor location, metastatic status, and UICC stage were significant predictors for both endpoints in univariate analysis. However, none of these association were confirmed in multivariate analyses. Conclusions: Very close surgical margins (<1 mm) may increase the risk of local recurrence in high-grade osteosarcoma; however, they do not appear to affect overall survival. Full article

Robotic assembly of electrical connectors enables the automation of high-efficiency production of electronic products. A rigid gripper is adopted as the end-effector by the majority of existing works with a force–torque sensor installed at the wrist, which suffers from very limited perception capability of the manipulated objects. Moreover, the grasping and movement actions, as well as the inconsistency between the robot base and the end-effector frame, tend to result in angular misalignment, usually leading to assembly failure. Bio-inspired by the human finger, we designed a tactile finger in this paper with three characteristics: (1) Compliance: A soft ‘skin’ layer provides passive compliance for plenty of manipulation actions, thus increasing the tolerance for alignment errors. (2) Tactile Perception: Two types of sensing elements are embedded into the soft skin to tactilely sense the involved contact status. (3) Enhanced manipulation force: A rigid fingernail is designed to enhance the manipulation force and enable potential delicate operations. Moreover, a tactile-based alignment algorithm is proposed to search for the optimal orientation angle about the z axis. In the application of U-disk insertion, the three characteristics are validated and a success rate of 100% is achieved, whose generalization capability is also validated through the assembly of three types of electrical connectors. Full article

Redwood (Sequoia sempervirens (Lamb. ex D. Don) Endl.) is a fast-growing, long-lived conifer native to a narrow coastal zone along the western seaboard of the United States. Redwood can accumulate very high amounts of carbon in plantation settings and continuous cover forestry (CCF) represents a highly profitable option, particularly for small-scale forest growers in the North Island of New Zealand. We evaluated the profitability of conceptual CCF regimes using two case study forests: Blue Mountain (109 ha, Taranaki Region, New Zealand) and Spring Creek (467 ha, Manawatu-Whanganui Region, New Zealand). We ran a strategic harvest scheduling model for both properties and used its results to guide a tactical-spatially explicit model harvesting small 0.7 ha units over a period that spanned 35 to 95 years after planting. The internal rates of return (IRRs) were 9.16 and 10.40% for Blue Mountain and Spring Creek, respectively, exceeding those considered robust for other forest species in New Zealand. The study showed that small owners could benefit from carbon revenue during the first 35 years after planting and then switch to a steady annual income from timber, maintaining a relatively constant carbon stock under a continuous cover forestry regime. Implementing adjacency constraints with a minimum green-up period of five years proved feasible. Although small coupes posed operational problems, which were linked to roading and harvesting, these issues were not insurmountable and could be managed with appropriate operational planning. Full article

Background/Objectives: Understanding the impact of dietary habits in terms of obesity, health outcomes, and functional decline is critical in Europe’s growing elderly population. This study analyzed trends in Mediterranean diet (MD) adherence, obesity prevalence, and grip strength among middle-aged and elderly Europeans using data from the Survey of Health, Ageing and Retirement in Europe (SHARE). Methods: Data from four SHARE waves (2015–2022) across 28 countries were analyzed. Dietary patterns were assessed through food frequency questionnaires classifying participants as MD-adherent or non-adherent where adherent implies daily consumption of fruits and vegetables and occasional (3–6 times/week) intake of eggs, beans, legumes, meat, fish, or poultry (an unvalidated definition of the MD pattern). Handgrip strength, a biomarker of functional capacity, was categorized into low, medium, and high groups. Body mass index (BMI), self-perceived health (SPHUS), chronic disease prevalence, and CASP-12 scores (control, autonomy, self-realization, and pleasure evaluated on the 12-item version) were also evaluated. Statistical analyses included descriptive methods, logistic regressions, and multiple imputations to address missing data. Results: A significant majority (74–77%) consumed fruits and vegetables daily, which is consistent with MD principles; however, the high daily intake of dairy products (>50%) indicates limited adherence to the MD, which advocates for moderate consumption of dairy products. Logistic regression indicated that individuals with two or more chronic diseases were more likely to follow the MD (odds ratio [OR] = 1.21, confidence interval [CI] = 1.11–1.32), as were those individuals who rated their SPHUS as very good/excellent ([OR] = 1.42, [CI] = 1.20–1.69). Medium and high maximal handgrip were also strongly and consistently associated with higher odds of MD adherence (Medium: [OR] = 1.44, [CI] = 1.18–1.74; High: [OR] = 1.27, [CI] = 1.10–1.48). Conclusions: The findings suggest that middle-aged and older adults are more likely to adhere to the MD dietary pattern if they have more than two chronic diseases, are physically active, and have a medium or high handgrip. Although an unvalidated definition of the MD dietary pattern was used, the results highlight the importance of implementing targeted dietary strategies for middle-aged and elderly adults. Full article

Background: Polymerase chain reaction (PCR) is highly sensitive and specific for the rapid diagnosis of invasive fungal disease (IFD) but is not yet widely implemented due to concerns regarding limited standardisation between assays, the lack of commercial options and the absence of clear guidance on interpreting results. Objectives and Methods: This review provides an update on technical and clinical aspects of PCR for the diagnosis of the most pertinent fungal pathogens, including Aspergillus, Candida, Pneumocystis jirovecii, Mucorales spp., and endemic mycoses. Summary: Recent meta-analyses have demonstrated that quantitative PCR (qPCR) offers high sensitivity for diagnosing IFD, surpassing conventional microscopy, culture and most serological tests. The reported specificity of qPCR is likely underestimated due to comparison with imperfect reference standards with variable sensitivity. Although the very low limit of detection of qPCR can generate false positive results due to procedural contamination or patient colonisation (particularly in pulmonary specimens), the rates are comparable to those observed for biomarker testing. When interpreting qPCR results, it is essential to consider the pre-test probability, determined by the patient population, host factors, clinical presentation and risk factors. For patients with low to moderate pre-test probability, the use of sensitive molecular tests, often in conjunction with serological testing or biomarkers, can effectively exclude IFD when all tests return negative results, reducing the need for empirical antifungal therapy. Conversely, for patients with high pre-test probability and clinical features of IFD, qPCR testing on invasive specimens from the site of infection (such as tissue or bronchoalveolar lavage fluid) can confidently rule in the disease. The development of next-generation sequencing methods to detect fungal infection has the potential to enhance the diagnosis of IFD, but standardisation and optimisation are essential, with improved accessibility underpinning clinical utility. Full article

Background/Objectives: The global population of individuals aged ≥ 80 years is rapidly growing, leading to an increasing incidence of cancer diagnoses in this age group. While stereotactic body radiotherapy (SBRT) has proven effective in treating pulmonary oligometastases, patients over 80 remain underrepresented in clinical analyses. This study aimed to evaluate clinical outcomes and toxicity of SBRT for pulmonary oligometastases in octogenarians. Methods: This retrospective, single-centre analysis included 34 patients aged ≥ 80 years treated with SBRT for histologically confirmed pulmonary oligometastases between 2010 and 2024. Results: A total of 46 pulmonary metastases were treated with curative intent using fractionation schemes of 3 × 15 Gy, 6 × 8 Gy, or 10 × 6 Gy. Median biologically effective dose (BED10) was 112.5 Gy. Follow-up included regular CT imaging and toxicity assessment according to CTCAE. With a median follow-up of 22.6 months, 1-, 2-, and 3-year local control (LC) rates were 95.2%, 95.2%, and 90.2%, respectively. Median overall survival (OS) was 46.6 months, with 1-, 2-, and 3-year OS rates of 78.4%, 71.4%, and 59.5%. Progression-free survival (PFS) at 1, 2, and 3 years was 63.4%, 51.6%, and 47.3%, respectively. No grade ≥ 3 toxicities were observed. Grade 2 pneumonitis and dermatitis occurred in 2.9% each and were well managed. Asymptomatic rib fractures were detected in 5.9% of patients. No significant predictors for LC, PFS, or OS were identified in univariate analysis. Conclusions: SBRT for pulmonary oligometastases in patients ≥ 80 years is feasible, safe, and effective. High local control, favourable cancer-specific survival, and minimal toxicity support its use as a curative-intent treatment in this growing patient population. These findings contribute important site- and age-specific evidence and support the inclusion of very elderly patients in future prospective SBRT trials. Full article

Hydraulic shear has been widely accepted as one of the essential factors modulating phytoplankton growth. Previous experimental studies of algal growth have been conducted at the macroscopic level, and direct observation at the cell scale has been lacking. In this study, an algal-cell dynamic continuous observation platform (ACDCOP) is proposed with a parallel-plate flow chamber (PPFC) to capture cellular growth images which are then used as input to a computer vision algorithm featuring a pre-trained backpropagation neural network to quantitatively evaluate the volumes and volumetric growth rates of individual cells. The platform was applied to investigate the growth of Scenedesmus quadricauda cells under different hydraulic shear stress conditions. The results indicated that the threshold shear stress for the development of Scenedesmus quadricauda cells was 270 µL min⁻¹ (5.62 × 10⁻⁵ m² s⁻³). Cellular growth was inhibited at very low and very high intensities of hydraulic shear. Among all the experimental groups, the longest growth period for a cell, from attachment to PPFC to cell division, was 5.7 days. Cells with larger initial volumes produced larger volumes at division. The proposed platform could provide a novel approach for algal research by enabling direct observation of algal growth at the cell scale, and could potentially be applied to investigate the impacts of various environmental stressors such as nutrient, temperature, and light on cellular growth in different algal species. Full article

Introduction. Singapore had previously embraced at least two types of pre-participation questionnaires for those intending to take up or enhance their level of physical activity (PA). Concern over the usefulness of and difficulty in understanding these questions led to the design of a Singapore Physical Activity Readiness Questionnaire (SPARQ). The primary objective of this study was to review the level of difficulty in understanding the seven SPARQ questions. Secondary objectives included the rate of identifying individuals as unfit for PA and to seek public feedback on this tool. Method. A public, cross-sectional survey on the SPARQ was carried out, obtaining participants’ bio-characteristics, having them completing the SPARQ and then providing feedback on the individual questions. Results. Of the 1136 who completed the survey, 35.7% would have required referral to a medical practitioner for further evaluation before the intended PA. Significant difficulty was experienced with one question, moderate difficulty with four and only slight difficulty with the remaining two. The length of the questions and use of technical terms were matters of concern. Suggestions were provided by the participants on possible amendments to the questions. Conclusions. The very high acceptance rate of the SPARQ will need to be tempered with modifications to the questions to enhance ease of understanding and use by members of the public. Full article

Maternal and child health during pregnancy is an important issue in global public health, and the classification accuracy of fetal cardiotocography (CTG), as a key tool for monitoring fetal health during pregnancy, is directly related to the effectiveness of early diagnosis and intervention. Due to the serious category imbalance problem of CTG data, traditional models find it challenging to take into account a small number of categories of samples, increasing the risk of leakage and misdiagnosis. To solve this problem, this paper proposes a two-step innovation: firstly, we design a method of adaptive adjustment of misclassification loss function weights (MAAL), which dynamically identifies and increases the focus on misclassified samples based on misclassification rates. Secondly, a primary and secondary correction network model (MAC-NET) is constructed to carry out secondary correction for the misclassified samples of the primary model. Experimental results show that the method proposed in this paper achieves 99.39% accuracy on the UCI publicly available fetal health dataset, and also obtains excellent performance on other domain imbalance datasets. This demonstrates that the model is not only effective in alleviating the problem of category imbalance, but also has very high clinical utility. Full article

Modern Western societies are “aging” at a very high rate, and more and more people require assistance and care. Old age has different faces, which is due to genetic conditions, as well as the different contexts and lifestyles of people. To ensure good adaptation of seniors, it is important to determine the conditions for “successful aging”. Therefore, the purpose of the conducted study was to determine the importance of selected predictors, including the level of religiosity, assessment of health, and the intensity of motivational needs of seniors—students of the University of the Third Age—for the level of their well-being. A total of 115 people were surveyed, including 93 women and 21 men who were students in the first year of the Third Age University at the Pontifical University of John Paul II in Krakow. The surveyed seniors represented an autonomous type of religiosity, a high level of realization of the needs of self-determination, namely autonomy and competence, declared an average assessment of the state of their health, and revealed an increased level of eudaimonic well-being. Predictors of the level of well-being of the surveyed seniors turned out to be the variables religious experience, need for autonomy and competence, and health status, as assessed by the seniors. Full article

The Yangtze River Delta urban agglomeration, characterized by high population density, an advanced transportation system, and a concentration of industrial activity, is one of the regions severely affected by O₃ pollution in central and eastern China. Using data collected from 251 monitoring stations between 2015 and 2025, this paper analyzed the spatio-temporal variation of 8 h O₃ concentrations and instances of exceedance. On the basis of exploring the influence of meteorological factors on regional 8 h O₃ concentration, the potential source contribution areas of pollutants under the exceedance condition were investigated using the HYSPLIT model. The results indicate a rapid increase in the 8 h O₃ concentration at a rate of 0.91 ± 0.98 μg·m⁻³·a⁻¹, with the average number of days exceeding concentration standards reaching 41.05 in the Yangtze River Delta urban agglomeration. Spatially, the 8 h O₃ concentrations were higher in coastal areas and lower in inland regions, as well as elevated in plains compared to hilly terrains. This distribution was significantly distinct from the concentration growth trend characterized by higher levels in the northwest and lower levels in the southeast. Furthermore, it diverged from the spatial characteristics where exceedances primarily occurred in the heavily industrialized northeastern region and the lightly industrialized central region, indicating that the growth and exceedance of 8 h O₃ concentrations were influenced by disparate factors. Local human activities have intensified the emissions of ozone precursor substances, which could be the key driving factor for the significant increase in regional 8 h O₃ concentrations. In the context of high temperatures and low humidity, this has contributed to elevated levels of 8 h O₃ concentrations. When wind speeds were below 2.5 m·s⁻¹, the proportion of 8 h O₃ concentrations exceeding the standards was nearly 0 under almost calm wind conditions, and it showed an increasing trend with rising wind speeds, indicating that the potential precursor sources that caused high O₃ concentrations originated occasionally from inland regions, with very limited presence within the study area. This observation implies that the main cause of exceedances was the transport effect of pollution from outside the region. Therefore, it is recommended that the Yangtze River Delta urban agglomeration adopt economic and technological compensation mechanisms within and between regions to reduce the emission intensity of precursor substances in potential source areas, thereby effectively controlling O₃ concentrations and improving public living conditions and quality of life. Full article

Despite advances in surgery, chemotherapy, and radiation treatments for pancreatic ductal adenocarcinoma (PDAC), 5-year survival rates remain at nearly 11%. Cholangiocarcinoma, while not as severe, also possesses similar survival rates. Fewer than 20% of patients are surgical candidates at time of diagnosis; therefore, it is imperative that alternative therapies are effective for non-surgical patients. There are several thermal ablative techniques, including radiofrequency ablation (RFA), high-intensity focused ultrasound (HIFU), microwave ablation (MWA), alcohol ablation, stereotactic body radiotherapy (SBRT), cryoablation, irreversible electroporation (IRE), biliary intraluminal brachytherapy, and biliary photodynamic therapy (PDT). Emerging literature in animal models and human patients has demonstrated that endoscopic ultrasound (EUS)-guided RFA (EUS-RFA) prevents tumor progression through coagulative necrosis, protein denaturation, and activation of anticancer immunity in local and distant tumor tissue (abscopal effect). RFA treatment has been shown to not only reduce tumor-associated immunosuppressive cells but also increase functional T cells in distant tumor cells not treated with RFA. The remarkable ability to reduce tumor progression and promote tumor microenvironment (TME) remodeling makes RFA a very promising non-surgical therapy technique that has the potential to reduce mortality in this patient population. EUS-RFA offers superior precision and safety compared to other ablation techniques for pancreatic and biliary cancers, due to real-time imaging capabilities and minimally invasive nature. Future research should focus on optimizing RFA protocols, exploring combination therapies with chemotherapy or immunotherapy, and expanding its use in patients with metastatic disease. This review article will explore the current data and underlying pathophysiology of EUS-RFA while also highlighting the role of ablative therapies as a whole in immune activation response. Full article

Polymer flooding is a widely used enhanced oil recovery (EOR) method for improving energy efficiency and reducing the carbon footprint of oil production. Optimizing polymer concentration is critical for maximizing recovery while minimizing economic and environmental costs. Here, we present a systematic experimental study which shows that even very low concentrations of polymers yield relatively high recovery rates at adverse mobility ratios (230 cP oil). A series of core flood experiments were conducted on Bentheimer sandstone rock, with polymer concentrations ranging from 40 ppm (1.35 cP) to 600 ppm (10.0 cP). Beyond a mobility ratio threshold, increasing polymer concentration did not significantly enhance recovery. This plateau in performance was attributed to the persistence of viscous fingering and oil crossflow into pre-established water channels. The study suggests that low concentrations of polymer may mobilize oil at high mobility ratios by making use of the pre-established water channels as transport paths for the oil and that the rheology of the polymer enhances this effect. These findings enable reductions in the polymer concentration in fields with adverse mobility ratios, leading to substantial reductions in chemical usage, energy consumption, and environmental impact of the extraction process. Full article

Background: Personalized medicine in axial spondyloarthritis (axSpA) requires accurate tools to assess inflammation and tailor disease monitoring. The role of traditional biomarkers such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) remains controversial due to limited sensitivity and variability across disease profiles. Objective: To compare the performance of ESR and CRP in different clinical scenarios of axSpA, including disease activity, functional impact, severity, disease duration, and exposure to biologic therapy. Methods: We conducted a cross-sectional analysis of 330 patients with axSpA. Correlations among ESR, CRP, and composite disease indices were evaluated. The discriminatory capacity of each biomarker for relevant clinical thresholds was analyzed using ROC curves and optimal cut-offs identified by the Youden index. Results: ESR showed broader correlations with disease impact and activity scores than CRP. While both markers had low sensitivity overall, they were highly specific for identifying patients with very high disease activity in select scenarios. ESR ≥ 8.5 mm/h and CRP ≥ 1.88 mg/dL were strongly discriminatory in patients not exposed to biologics. CRP ≥ 0.56 mg/dL showed good performance in early disease. Conclusions: Both ESR and CRP provide complementary insights into disease activity in axSpA. ESR may offer a broader reflection of disease burden beyond inflammation. These results support a more personalized biomarker strategy in real-world axSpA management, adapted to patient profile and treatment context. Full article