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Search Results (185)

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20 pages, 819 KB  
Article
Multiplatform Computing of Transition Probabilities in Os V
by Patrick Palmeri, Saturnin Enzonga Yoca, Exaucé Bokamba Motoumba, Alix Niels, Maxime Brasseur and Pascal Quinet
Atoms 2026, 14(3), 22; https://doi.org/10.3390/atoms14030022 - 11 Mar 2026
Viewed by 279
Abstract
Osmium is an element of the Periodic Table with an atomic number Z equal to 76. In Tokamaks with divertors made of tungsten (Z=74), it is produced in the neutron-induced transmutation of the latter. Therefore one can expect that [...] Read more.
Osmium is an element of the Periodic Table with an atomic number Z equal to 76. In Tokamaks with divertors made of tungsten (Z=74), it is produced in the neutron-induced transmutation of the latter. Therefore one can expect that their sputtering may generate ionic impurities of all possible charge states in the fusion plasma. As a consequence, these could contribute to radiation losses in these controlled nuclear devices. The knowledge of radiative rates in all the spectra of osmium is thus important in this field. In this framework, a multiplatform approach has been used to determine the Os V radiative properties and estimate their accuracy. The transition probabilities have been computed for the 2677 electric dipole (E1) transitions falling in the spectral range from 400 Å to 12,000 Å. Three independent atomic structure models have been considered; one based on the fully relativistic ab initio multiconfiguration Dirac–Hartree–Fock (MCDHF) method and two based on the semi-empirical pseudo-relativistic Hartree–Fock (HFR) method. Full article
(This article belongs to the Section Atomic, Molecular and Nuclear Spectroscopy and Collisions)
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20 pages, 32011 KB  
Article
Settlement Model and State-Induced Demographic Trap: Hybrid Warfare Scenario and Territorial Transmutation in Spain
by Samuel Esteban Rodríguez, Zhaoyang Liu and Júlia Maria Nogueira Silva
Sustainability 2026, 18(3), 1162; https://doi.org/10.3390/su18031162 - 23 Jan 2026
Viewed by 511
Abstract
This study investigates the demographic transformation of Spain’s settlement system from 2000 to the present, driven by intersecting forces of rural depopulation, metropolitan concentration, immigration, and welfare-state dynamics. Building on an integrated theoretical framework that combines Maslow’s hierarchy of needs, demographic accounting, territorial [...] Read more.
This study investigates the demographic transformation of Spain’s settlement system from 2000 to the present, driven by intersecting forces of rural depopulation, metropolitan concentration, immigration, and welfare-state dynamics. Building on an integrated theoretical framework that combines Maslow’s hierarchy of needs, demographic accounting, territorial carrying capacity, and spatial centrality, the research aims to (1) identify the mechanisms governing population redistribution across Spanish municipalities, and (2) simulate future demographic trajectories under current policy regimes. Key findings reveal that all net population growth since 2000 stems exclusively from immigration and its demographic sequelae, while the native Spanish cohort has experienced a net decline of 5.5 million due to negative natural change. The analysis further uncovers a self-reinforcing “demographic trap,” wherein welfare eligibility tied to household size incentivizes higher fertility among economically vulnerable immigrant groups, even as native families delay childbearing due to economic precarity. These dynamics are accelerating a process of “territorial transmutation,” projected to culminate in a shift in de facto governance by 2045. The study concludes that immigration alone cannot reverse rural depopulation or ensure fiscal sustainability without structural reforms to welfare design, territorial incentives, and demographic foresight. Full article
(This article belongs to the Section Health, Well-Being and Sustainability)
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17 pages, 440 KB  
Article
The Systematic Reconfiguration in the Body Cultivation of Daoist Medicine: The Internal Boxing’s Incorporation of the “Desire Transformation” Techniques from the Internal Alchemy Tradition
by Zhanguo Peng, Feifei Yan and Haitao Du
Religions 2026, 17(1), 60; https://doi.org/10.3390/rel17010060 - 5 Jan 2026
Viewed by 1071
Abstract
Internal Boxing (neijiaquan 內家拳) is an advanced form of the Daoist gymnastic exercise of daoyin (導引). However, how it achieves a paradigmatic shift from qi/blood regulation to deep-level transmutation of sexual energy still requires further exploration. Therefore, it is of great [...] Read more.
Internal Boxing (neijiaquan 內家拳) is an advanced form of the Daoist gymnastic exercise of daoyin (導引). However, how it achieves a paradigmatic shift from qi/blood regulation to deep-level transmutation of sexual energy still requires further exploration. Therefore, it is of great significance to look into how Internal Boxing inheres and integrates various techniques of “desire transmutation” (zhuanyu 轉欲) from internal alchemy (neidan 內丹), thereby transcending traditional daoyin, bringing about a significant systematic reconfiguration in the model of body cultivation practices in Daoist medicine. The traditional daoyin (i.e., “guiding and stretching”) practice emphasizes the regulation of qi/blood, but it remains limited in accounting for and producing the self-conscious transmutation of sexual energy. In contrast, Internal alchemy provides a different system of theory and techniques, which is centered on the concept of “transmutation of desires”, converting human desires into high-level life energy through a process of interaction between one’s internal spirit (xinshen 心神) and internal breathing (neixi 內息). This study thus examines the ways in which Internal Boxing integrates and reconfigures these techniques within its bodily training regimen. In the core of all these styles is the goal to refine the primordial essence (yuanjing 元精) by transitioning the method to induce the flow of vital energy from breathing to somatic movements. As a result, this study shows that the innovations of Internal Boxing reconfigure the qi/blood regulation model in the traditional daoyin practice, causing a systematic reconfiguration in the transmutation of sexual energy and, further, bridging the gap between daoyin and internal alchemy in both theory and practice. Furthermore, such innovations also develop a holistic view of the human body as marked by an emphasis on the “unity of pre-heaven (xiantian 先天) and post-heaven (houtian 後天) states”, which expands in both depth and breadth the theories of body cultivation practices in Daoist medicine. Full article
14 pages, 1639 KB  
Review
Review of Radiation Embrittlement of Aluminum Alloys Used in Research Reactors
by Ferenc Gillemot, Murthy Kolluri, Ildiko Szenthe, Frideriki Naziris and Lajos Berzy
Materials 2025, 18(22), 5236; https://doi.org/10.3390/ma18225236 - 19 Nov 2025
Cited by 1 | Viewed by 963
Abstract
Research reactors are generally built from aluminum alloys during the last century. Most of the operation times of them already exceed the design lifetime. The original mechanical properties change during service. The radiation embrittlement affects them through three mechanisms: the transmutation of aluminum [...] Read more.
Research reactors are generally built from aluminum alloys during the last century. Most of the operation times of them already exceed the design lifetime. The original mechanical properties change during service. The radiation embrittlement affects them through three mechanisms: the transmutation of aluminum to silicon caused by thermal neutrons, gases (hydrogen, helium) occur by fast neutron transmutation, causing swelling, and matrix defects (dislocations, voids) occur by fast neutron irradiation. This paper summarizes the existing knowledge of the radiation degradation of aluminum alloys. Full article
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18 pages, 3546 KB  
Article
Monte Carlo-Based Simulation of Reactivity and Transmutation in the CEFR Sodium-Cooled Fast Reactor
by Jianquan Liu, Rongbin Shang, Jie Tan, Rui Zhang, Yuqian Meng, Yubo Chen and Lin Li
Appl. Sci. 2025, 15(21), 11534; https://doi.org/10.3390/app152111534 - 28 Oct 2025
Viewed by 820
Abstract
As a representative Generation IV sodium-cooled fast reactor (Gen-IV SFR), neutron physics characteristics studies of the China Experimental Fast Reactor (CEFR) core are crucial for its safety case. In this study, a three-dimensional core model of the CEFR was developed using the Monte [...] Read more.
As a representative Generation IV sodium-cooled fast reactor (Gen-IV SFR), neutron physics characteristics studies of the China Experimental Fast Reactor (CEFR) core are crucial for its safety case. In this study, a three-dimensional core model of the CEFR was developed using the Monte Carlo-based MCNP5 code, with its reliability validated through five neutronics benchmark experiments. Based on this model, the fundamental neutronics characteristics of minor actinide (MA) transmutation in the sodium-cooled fast reactor were investigated. The results demonstrate that as the minor actinide (MA) loading fraction in the core increases from 0% to 8%, the effective multiplication factor (Keff) exhibits a significantly nonlinear decrease, accompanied by a corresponding reduction in neutron flux, necessitating increased fuel enrichment to maintain core criticality. Opposite impacts on reactivity are observed for different MA nuclides: 237Np, 241Am, 243Am and mixed MA reduce Keff, whereas 244Cm and particularly 245Cm significantly enhance Keff. The reactivity change rate sharply decreased from −1242.5 to −312.7 pcm/wt%, clearly demonstrating saturation effects in MA neutron absorption. Crucially, reactivity remained deeply negative across all operational scenarios, with safety requirements being satisfied even at maximum MA loading levels, confirming the inherent safety of the proposed approach. Full article
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17 pages, 505 KB  
Article
On Doubly-Generalized-Transmuted Distributions
by Barry C. Arnold, Yolanda M. Gómez, Diego I. Gallardo and Héctor W. Gómez
Symmetry 2025, 17(10), 1606; https://doi.org/10.3390/sym17101606 - 27 Sep 2025
Cited by 1 | Viewed by 518
Abstract
Many parametric models can be enriched by introducing additional parameters through transmutation, mixing, or compounding techniques. In this paper, we develop the framework of doubly generalized transmutation models (DGTMs), obtained by the repeated application of rank transmutation maps and their generalizations. We show [...] Read more.
Many parametric models can be enriched by introducing additional parameters through transmutation, mixing, or compounding techniques. In this paper, we develop the framework of doubly generalized transmutation models (DGTMs), obtained by the repeated application of rank transmutation maps and their generalizations. We show that several flexible families already available in the literature can be reinterpreted as instances of double or multiple transmutation, thus unifying apparently disparate constructions under a common perspective. A key feature of DGTMs is their ability to flexibly control symmetry through parameterization, enabling more accurate modeling of asymmetric or heavy-tailed phenomena. We also discuss the potential extension of these models to the bivariate case. In addition, we introduce the gentransmuted R package, Version 1.0, which provides routines for data generation, parameter estimation, and model comparison for generalized transmutation models. Two real data applications illustrate the practical advantages of this approach, highlighting improved model fit relative to classical alternatives. Our results underscore the value of transmutation-based methods as a systematic tool for generating flexible probability distributions and advancing their computational implementation. Full article
(This article belongs to the Special Issue Mathematics: Feature Papers 2025)
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15 pages, 2035 KB  
Article
Real-Time Technique for Semiconductor Material Parameter Measurement Under Continuous Neutron Irradiation with High Integral Fluence
by Ivan S. Vasil’evskii, Aleksey N. Klochkov, Pavel V. Nekrasov, Aleksander N. Vinichenko, Nikolay I. Kargin, Almas Yskakov, Maksim V. Bulavin, Aleksey V. Galushko, Askhat Bekbayev, Bagdaulet Mukhametuly, Elmira Myrzabekova, Nurdaulet Shegebayev, Dana Kulikbayeva, Rassim Nurulin, Aru Nurkasova and Ruslan Baitugulov
Electronics 2025, 14(19), 3802; https://doi.org/10.3390/electronics14193802 - 25 Sep 2025
Viewed by 967
Abstract
The degradation of the electronic properties of semiconductor materials and electronic devices under neutron irradiation is a critical issue for the development of electronic systems intended for use in nuclear and thermonuclear energy facilities. This study presents a methodology for real-time measurement of [...] Read more.
The degradation of the electronic properties of semiconductor materials and electronic devices under neutron irradiation is a critical issue for the development of electronic systems intended for use in nuclear and thermonuclear energy facilities. This study presents a methodology for real-time measurement of the electrical parameters of semiconductor structures during neutron irradiation in a high-flux reactor environment. A specially designed irradiation fixture with an electrical measurement system was developed and implemented at the WWR-K research reactor. The system enables simultaneous measurement of electrical conductivity and the Hall effect, with automatic temperature control and remote data acquisition. The sealed fixture, equipped with radiation-resistant wiring and a temperature control, allows for continuous measurement of remote material properties at neutron fluences exceeding 1018 cm−2, eliminating the limitations associated with post-irradiation handling of radioactive samples. The technique was successfully applied to the two different InGaAs-based heterostructures, revealing distinct mechanisms of radiation-induced modification: degradation of mobility and carrier concentration in the InGaAs quantum well structure on GaAs substrate, and transmutation-induced doping effects in the heterostructure on InP substrate. The developed methodology provides a reliable platform for evaluating radiation resistance and optimizing materials for magnetic sensors and electronic components designed for high-radiation environments. Full article
(This article belongs to the Special Issue Radiation Effects on Advanced Electronic Devices and Circuits)
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16 pages, 3147 KB  
Article
A Note on Multi-Index Mittag-Leffler Functions and Parametric Laguerre-Type Exponentials
by Hari Mohan Srivastava, Diego Caratelli and Paolo Emilio Ricci
Axioms 2025, 14(9), 705; https://doi.org/10.3390/axioms14090705 - 18 Sep 2025
Cited by 1 | Viewed by 882
Abstract
This paper explores the eigenfunctions of specific Laguerre-type parametric operators to develop multi-parametric models, which are associated with a class of the generalized Mittag-Leffler type functions, for dynamical systems and population dynamics. By leveraging these multi-parametric approaches, we introduce new concepts in number [...] Read more.
This paper explores the eigenfunctions of specific Laguerre-type parametric operators to develop multi-parametric models, which are associated with a class of the generalized Mittag-Leffler type functions, for dynamical systems and population dynamics. By leveraging these multi-parametric approaches, we introduce new concepts in number theory, specifically those involving multi-parametric Bernoulli and Euler numbers, along with other related polynomials. Several numerical examples, which are generated by using the computer algebra program Mathematica© (Version 14.3), demonstrate the effectiveness of the models that we have presented and analyzed in this paper. Full article
(This article belongs to the Special Issue Special Functions and Related Topics, 2nd Edition)
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27 pages, 1578 KB  
Article
Tapio-Z Decoupling of the Valuation of Energy Sources, CO2 Emissions, and GDP Growth in the United States and China Using a Fuzzy Logic Model
by Rabnawaz Khan and Weiqing Zhuang
Energies 2025, 18(15), 4188; https://doi.org/10.3390/en18154188 - 7 Aug 2025
Cited by 1 | Viewed by 1356
Abstract
Our contemporary society is powered by fossil fuels, which results in environmental catastrophes. The combustion of these materials results in the release of CO2, which accelerates the progression of climate change and its catastrophic consequences. The environmental repercussions of fossil fuel [...] Read more.
Our contemporary society is powered by fossil fuels, which results in environmental catastrophes. The combustion of these materials results in the release of CO2, which accelerates the progression of climate change and its catastrophic consequences. The environmental repercussions of fossil fuel extraction have been highlighted through research into alternative energy sources. This inquiry uses the Tapio-Z decoupling approach to assess energy inputs and emissions. Furthermore, the fuzzy logic model is used to inspect the economic growth of the USA and China, as well as the impact of environmental factors, energy sources, and utilization, through decoupling effects from 1994 to 2023. The findings are substantiated by the individual perspectives of the environmental factors regarding decoupling, which ultimately lead to the acquisition of valuable results. We anticipate a substantial reduction in the total volume of CO2 emissions in both the USA and China. Compared to China, the USA shows a significant increase in CO2 emissions due to its reliance on fossil fuels. It is evident that a comprehensive transition to renewable resources and a broad range of technology is required to mitigate CO2 emissions in high-energy zones. In their pursuit of sustainability, these two nations are making remarkable strides. The percentage change in CO2 emissions indicates that effective changes in economic growth, energy input, and energy utilization, particularly sustainable energy, transmute energy output, as does the sustained implementation of robust environmental protection policies. The percentage change in CO2 emissions indicates a remarkable transformation in energy input, energy consumption, and economic growth. This transition has been most visible in the areas of energy transformation, sustainability, and the maintenance of strong environmental protection measures. Full article
(This article belongs to the Special Issue Energy Transition and Environmental Sustainability: 3rd Edition)
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12 pages, 2376 KB  
Article
Investigating Helium-Induced Thermal Conductivity Degradation in Fusion-Relevant Copper: A Molecular Dynamics Approach
by Xu Yu, Hanlong Wang and Hai Huang
Materials 2025, 18(15), 3702; https://doi.org/10.3390/ma18153702 - 6 Aug 2025
Cited by 2 | Viewed by 1081
Abstract
Copper alloys are critical heat sink materials for fusion reactor divertors due to their high thermal conductivity (TC) and strength, yet their performance under extreme particle bombardment and heat fluxes in future tokamaks requires enhancement. While neutron-induced transmutation helium affects the properties of [...] Read more.
Copper alloys are critical heat sink materials for fusion reactor divertors due to their high thermal conductivity (TC) and strength, yet their performance under extreme particle bombardment and heat fluxes in future tokamaks requires enhancement. While neutron-induced transmutation helium affects the properties of copper, the atomistic mechanisms linking helium bubble size to thermal transport remain unclear. This study employs non-equilibrium molecular dynamics (NEMD) simulations to isolate the effect of bubble diameter (10, 20, 30, 40 Å) on TC in copper, maintaining a constant He-to-vacancy ratio of 2.5. Results demonstrate that larger bubbles significantly impair TC. This reduction correlates with increased Kapitza thermal resistance and pronounced lattice distortion from outward helium diffusion, intensifying phonon scattering. Phonon density of states (PDOS) analysis reveals diminished low-frequency peaks and an elevated high-frequency peak for bubbles >30 Å, confirming phonon confinement and localized vibrational modes. The PDOS overlap factor decreases with bubble size, directly linking microstructural evolution to thermal resistance. These findings elucidate the size-dependent mechanisms of helium bubble impacts on thermal transport in copper divertor materials. Full article
(This article belongs to the Special Issue Advances in Computation and Modeling of Materials Mechanics)
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27 pages, 1491 KB  
Article
Spent Nuclear Fuel—Waste to Resource, Part 1: Effects of Post-Reactor Cooling Time and Novel Partitioning Strategies in Advanced Reprocessing on Highly Active Waste Volumes in Gen III(+) UOx Fuel Systems
by Alistair F. Holdsworth, Edmund Ireland and Harry Eccles
J. Nucl. Eng. 2025, 6(3), 29; https://doi.org/10.3390/jne6030029 - 5 Aug 2025
Cited by 3 | Viewed by 3068
Abstract
Some of nuclear power’s primary detractors are the unique environmental challenges and impacts of radioactive wastes generated during fuel cycle operations. Key benefits of spent fuel reprocessing (SFR) are reductions in primary high active waste (HAW) masses, volumes, and lengths of radiotoxicity at [...] Read more.
Some of nuclear power’s primary detractors are the unique environmental challenges and impacts of radioactive wastes generated during fuel cycle operations. Key benefits of spent fuel reprocessing (SFR) are reductions in primary high active waste (HAW) masses, volumes, and lengths of radiotoxicity at the expense of secondary waste generation and high capital and operational costs. By employing advanced waste management and resource recovery concepts in SFR beyond the existing standard PUREX process, such as minor actinide and fission product partitioning, these challenges could be mitigated, alongside further reductions in HAW volumes, masses, and duration of radiotoxicity. This work assesses various current and proposed SFR and fuel cycle options as base cases, with further options for fission product partitioning of the high heat radionuclides (HHRs), rare earths, and platinum group metals investigated. A focus on primary waste outputs and the additional energy that could be generated by the reprocessing of high-burnup PWR fuel from Gen III(+) reactors using a simple fuel cycle model is used; the effects of 5- and 10-year spent fuel cooling times before reprocessing are explored. We demonstrate that longer cooling times are preferable in all cases except where short-lived isotope recovery may be desired, and that the partitioning of high-heat fission products (Cs and Sr) could allow for the reclassification of traditional raffinates to intermediate level waste. Highly active waste volume reductions approaching 50% vs. PUREX raffinate could be achieved in single-target partitioning of the inactive and low-activity rare earth elements, and the need for geological disposal could potentially be mitigated completely if HHRs are separated and utilised. Full article
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23 pages, 2231 KB  
Review
Advanced Nuclear Reactors—Challenges Related to the Reprocessing of Spent Nuclear Fuel
by Katarzyna Kiegiel, Tomasz Smoliński and Irena Herdzik-Koniecko
Energies 2025, 18(15), 4080; https://doi.org/10.3390/en18154080 - 1 Aug 2025
Cited by 6 | Viewed by 6146
Abstract
Nuclear energy can help stop climate change by generating large amounts of emission-free electricity. Nuclear reactor designs are continually being developed to be more fuel efficient, safer, easier to construct, and to produce less nuclear waste. The term advanced nuclear reactors refers either [...] Read more.
Nuclear energy can help stop climate change by generating large amounts of emission-free electricity. Nuclear reactor designs are continually being developed to be more fuel efficient, safer, easier to construct, and to produce less nuclear waste. The term advanced nuclear reactors refers either to Generation III+ and Generation IV or small modular reactors. Every reactor is associated with the nuclear fuel cycle that must be economically viable and competitive. An important matter is optimization of fissile materials used in reactor and/or reprocessing of spent fuel and reuse. Currently operating reactors use the open cycle or partially closed cycle. Generation IV reactors are intended to play a significant role in reaching a fully closed cycle. At the same time, we can observe the growing interest in development of small modular reactors worldwide. SMRs can adopt either fuel cycle; they can be flexible depending on their design and fuel type. Spent nuclear fuel management should be an integral part of the development of new reactors. The proper management methods of the radioactive waste and spent fuel should be considered at an early stage of construction. The aim of this paper is to highlight the challenges related to reprocessing of new forms of nuclear fuel. Full article
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19 pages, 3813 KB  
Article
Dual Policy–Market Orchestration: New R&D Institutions Bridging Innovation and Entrepreneurship
by Yinhai Fang and Xinping Qiu
Adm. Sci. 2025, 15(8), 289; https://doi.org/10.3390/admsci15080289 - 24 Jul 2025
Cited by 1 | Viewed by 1833
Abstract
This study investigates how new R&D institutions mediate policy–market disjunctures to foster integrated innovation and entrepreneurship ecosystems. Employing a longitudinal case analysis (2013–2023) of the Jiangsu Industrial Technology Research Institute (JITRI), we delineate a three-phase evolutionary process: (1) an initial government-dominated phase, stimulating [...] Read more.
This study investigates how new R&D institutions mediate policy–market disjunctures to foster integrated innovation and entrepreneurship ecosystems. Employing a longitudinal case analysis (2013–2023) of the Jiangsu Industrial Technology Research Institute (JITRI), we delineate a three-phase evolutionary process: (1) an initial government-dominated phase, stimulating foundational capability development through contract R&D; (2) a subsequent marketization phase, enabling systemic resource integration via co-creation centers and global networks; and (3) a culminating synergy phase, where policy–market alignment facilitates ecosystem optimization through crowdsourced R&D and cross-domain collaboration. Three core mechanisms underpin this adaptation: policy–market coupling (providing external momentum), endogenous capability development (absorption to innovation), and dynamic resource orchestration (acquisition to optimization). JITRI’s hybrid governance model demonstrates that stage-contingent interventions—specifically, policy anchoring in early stages followed by market-responsive resource allocation—effectively transmute inherent tensions into productive synergies. These findings yield implementable frameworks for structuring innovative ecosystems and underscore the necessity for comparative studies to establish broader theoretical generalizability. Full article
(This article belongs to the Section International Entrepreneurship)
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31 pages, 1168 KB  
Article
A Seasonal Transmuted Geometric INAR Process: Modeling and Applications in Count Time Series
by Aishwarya Ghodake, Manik Awale, Hassan S. Bakouch, Gadir Alomair and Amira F. Daghestani
Mathematics 2025, 13(15), 2334; https://doi.org/10.3390/math13152334 - 22 Jul 2025
Viewed by 1023
Abstract
In this paper, the authors introduce the transmuted geometric integer-valued autoregressive model with periodicity, designed specifically to analyze epidemiological and public health time series data. The model uses a transmuted geometric distribution as a marginal distribution of the process. It also captures varying [...] Read more.
In this paper, the authors introduce the transmuted geometric integer-valued autoregressive model with periodicity, designed specifically to analyze epidemiological and public health time series data. The model uses a transmuted geometric distribution as a marginal distribution of the process. It also captures varying tail behaviors seen in disease case counts and health data. Key statistical properties of the process, such as conditional mean, conditional variance, etc., are derived, along with estimation techniques like conditional least squares and conditional maximum likelihood. The ability to provide k-step-ahead forecasts makes this approach valuable for identifying disease trends and planning interventions. Monte Carlo simulation studies confirm the accuracy and reliability of the estimation methods. The effectiveness of the proposed model is analyzed using three real-world public health datasets: weekly reported cases of Legionnaires’ disease, syphilis, and dengue fever. Full article
(This article belongs to the Special Issue Applied Statistics in Real-World Problems)
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17 pages, 2829 KB  
Article
Apparatus and Experiments Towards Fully Automated Medical Isotope Production Using an Ion Beam Accelerator
by Abdulaziz Yahya M. Hussain, Aliaksandr Baidak, Ananya Choudhury, Andy Smith, Carl Andrews, Eliza Wojcik, Liam Brown, Matthew Nancekievill, Samir De Moraes Shubeita, Tim A. D. Smith, Volkan Yasakci and Frederick Currell
Instruments 2025, 9(3), 18; https://doi.org/10.3390/instruments9030018 - 18 Jul 2025
Viewed by 1556
Abstract
Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated [...] Read more.
Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated system for the agile and reliable production of radiopharmaceuticals. The system performs transmutations, dissolution, and separation for a range of radioisotopes. Steps in the production of 89Zr-oxalate are used as an exemplar to illustrate its use. Three-dimensional (3D) printing was exploited to design and manufacture a target holder able to include solid targets, in this case an 89Y foil. Spot welding was used to attach 89Y to a refractory tantalum (Ta) substrate. A commercially available CPU chiller was repurposed to efficiently cool the metal target. Furthermore, a commercial resin (ZR Resin) and compact peristaltic pumps were employed in a compact (10 × 10 × 10 cm3) chemical separation unit that operates automatically via computer-controlled software. Additionally, a standalone 3D-printed unit was designed with three automated functionalities: photolabelling, vortex mixing, and controlled heating. All components of the assembly, except for the target holder, are housed inside a commercially available hot cell, ensuring safe and efficient operation in a controlled environment. This paper details the design, construction, and modelling of the entire assembly, emphasising its innovative integration and operational efficiency for widespread radiopharmaceutical automation. Full article
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