Search Results (423)

This study describes the processing of microneedle (MN) arrays with three different heights of arrowhead (600 µm (A1), 800 µm (A2), and 1000 µm (A3)), pyramid (600 µm (P1), 800 µm (P2), and 1000 µm (P3)), and turret (600 µm (T1), 800 µm (T2), and 1000 µm (T3)) designs using a digital light processing (DLP)-based 3D printing method. The 3D-printed MNs were examined for their morphological characteristics and mechanical performance. Scanning electron microscopy (SEM) imaging confirmed that all of the MNs were fabricated without fracture or bending. Each design exhibited distinct structural characteristics: arrowhead MNs displayed a well-defined morphology with sharp tips, pyramid MNs showed slight layering, and turret MNs, characterized by a wider base and sharp tips, had a smoother surface compared to the other designs. Mechanical tests revealed that the arrowhead MNs carried less load and were more prone to bending, while the pyramid and turret designs provided higher mechanical stability and penetration capacity. The pyramid design (P3) showed the highest mechanical strength, while turret MNs offered a more stable performance despite lower penetration capacity. These findings highlight the critical role of geometric design in optimizing MN performance for effective transdermal drug delivery. Full article

Small-scale wind turbines are becoming increasingly important in renewable energy systems due to their ability to operate in low-wind-speed environments and adapt to various installation locations, especially in areas with energy shortages. This paper presents the design, analysis and development of a Helical Vertical Axis type Wind Turbine (H-VAWT) using uPVC pipe as the blade material, offering a lightweight, low-cost, and corrosion resistant solution. The blade structure is optimized for use in residential and off-grid areas with unstable wind conditions. Structural analysis is conducted in ANSYS, including static load analysis (deformation, equivalent stress, shear stress, maximum stress), torsional and bending stress, and modal analysis to assess mechanical performance and vibrational stability. Three blade designs are initially considered, and the helical model (0–45° twist) is selected based on simulation results. The prototype is successfully fabricated and tested under different wind speeds, showing effective power generation, with favorable results in power output, power coefficient, tip-speed ratio (TSR), and relative velocity. Full article

Immersion deep ultraviolet (DUV) lithography remains an indispensable core technology in advanced integrated circuit manufacturing, particularly when combined with multiple patterning techniques to achieve sub-10 nm feature patterning. However, at advanced technology nodes, dynamic instabilities of DUV light sources—including spectral characteristics (bandwidth fluctuations, and center wavelength drift), coherence variations, and pulse-to-pulse energy instability—can adversely affect imaging contrast, normalized image log-slope (NILS), and critical dimension (CD) uniformity. To quantitatively assess the impact of laser parameter fluctuations on NILS and CD, this work establishes systematic physical models for imaging perturbations caused by multi-parameter laser output instabilities under immersion DUV lithography. Through simulations, we evaluate the influence of laser parameter variations on the imaging fidelity of representative line/space (L/S) and tip-to-line (T2L) structures, thereby validating the proposed perturbation model. Research demonstrates that the spectral attributes (bandwidth fluctuation and center wavelength drift), coherence variations, and pulse energy instability collectively induce non-uniform electric field intensity distribution within photoresist, degrading NILS, and amplifying CD variation, which ultimately compromise pattern fidelity and chip yield. Notably, at advanced nodes, pulse energy fluctuation exerts a significantly greater influence on imaging errors compared to bandwidth and wavelength variations. To satisfy the 10% process window requirement for 45 nm linewidths, pulse energy fluctuations should be rigorously confined within 1%. This research provides theoretical foundations and practical insights for the design of dynamic stability control of light source and process optimization of next-generation DUV light sources. Full article

Pinus yunnanensis, is an ecologically and economically important tree species in southwestern China. However, its natural renewal is relatively lagging behind, and it is difficult to achieve sustainable development. Apical removal (top-pruning) can eliminate apical dominance, stimulate sprouting, and provide high-quality scions for clonal propagation. Root systems are a critical foundation for sprouting capacity. In this study, one-year-old P. yunnanensis seedlings were subjected to four treatments: removal of 3/4 (H1), 2/4 (H2), or 1/4 (H3) of the seedling height, and a non-topped control group (CK). The objective was to investigate the seedlings’ responses in terms of root morphology, biomass allocation, and allometric growth. The results showed that by May, biomass allocation in the topped treatments increased by 13.37%, 11.01%, and 7.86%, respectively, compared with the control, and also exhibited higher coefficients of variation. Under the H2 treatment, both fine and coarse roots accounted for a higher proportion of total root biomass and displayed stronger water-retention stability. With increased top-pruning intensity and time, root volume, specific root length, root tissue density, and root tip number were the first to respond, indicating the onset of allometric growth. Notably, in May, the growth rate of specific root surface area followed the order: H3 > H1 > CK > H2. These findings suggest that the root system adapts to environmental changes by modulating growth patterns among various indicators to optimize resource allocation and enhance adaptability. Full article

This study aims to enhance total pressure probe performance in transonic axial compressors using passive flow control via circular grooves. Simulations in ANSYS CFX were performed on six probe configurations, one smooth baseline and five with groove depths of 0.1 to 0.5 mm, across Mach numbers 0.3 to 0.86. The 0.1 mm grooved probe showed optimal results, reducing the drag coefficient from 15.23 to 14.33 and the lift from 0.0169 to 0.0042. A spanwise analysis from the hub to tip (55–95%) confirmed improved flow uniformity, while a streamwise analysis (zones 0–2) showed steadier downstream pressure and reduced wake-induced distortion. The 0.1 mm groove also minimized the shock strength and flow separation near blade tips. Results confirm that micro-grooving at 0.1 mm significantly stabilizes measurements and enhances aerodynamic efficiency, offering a practical optimization strategy for high-speed compressor applications. Full article

This review presents a comprehensive overview of metallic abradable coatings and the advanced testing methodologies used to evaluate their performance in gas turbine engines. Abradable materials are engineered to act as sacrificial coatings, enabling minimal blade tip wear while maintaining tight clearances between rotating blades and stationary components. Such functionality is critical in aerospace applications, where engines operate at high rotational speeds and across wide temperature ranges. The review examines the principal factors governing the design and selection of metallic-based abradable coatings, including material composition, thermal stability, and microstructural tailoring through the addition of phase modifiers, porosity formers, and solid lubricants. The performance of various metallic matrix materials is also discussed concerning their operational temperature ranges and wear characteristics. Particular attention is given to abradability evaluation methods, emphasizing the need to replicate engine-representative conditions to capture blade–coating interactions, frictional behavior, and wear mechanisms. This review consolidates advances in material compositions, microstructural engineering, and experimental testing, integrating perspectives from materials science, tribology, and methodology to guide the development of next-generation turbine coatings. It specifically addresses the lack of a unified review linking material design, thermal spray processes, and performance evaluation by summarizing key compositions, microstructures, and testing methods. Full article

This study investigates the potential of porous poly(D,L-lactide) (PDLLA) scaffolds reinforced with graphene oxide (GO) for bone tissue engineering applications. Scaffolds were fabricated using thermally induced phase separation (TIPS) and characterized in terms of morphology, biodegradation, thermal and mechanical properties, and cytocompatibility. The incorporation of GO enhanced both mechanical strength and thermal stability, likely due to hydrogen bonding and electrostatic interactions between GO’s functional groups (carbonyl, carboxyl, epoxide, and hydroxyl) and PDLLA chains. In vitro degradation studies showed that GO accelerated degradation, while scaffolds with higher GO content retained superior mechanical strength. Cytotoxicity assays confirmed the biocompatibility of all scaffold variants, supporting their suitability for biomedical applications. Overall, the findings demonstrate how GO incorporation can modulate scaffold composition and performance. This provides insights for the design of improved systems for bone tissue regeneration. Full article

We present a hybrid partial differential equation-agent-based model (PDE-ABM). In our framework, tumor cells secrete tumor angiogenic factor (TAF), while endothelial cells chemotactically migrate and branch in response. Reaction–diffusion PDEs for TAF, oxygen, and cytotoxic drug are coupled to discrete stochastic dynamics of tumor cells and endothelial tip cells, ensuring multiscale integration. Motivated by observed perfusion heterogeneity in tumors and its pharmacokinetic consequences, we conduct a linear stability analysis for a reduced endothelial–TAF reaction–diffusion subsystem and derive an explicit finite-domain threshold for Turing instability. We demonstrate that bidirectional coupling, where endothelial cells both chemotactically migrate along TAF gradients and secrete TAF, is necessary and sufficient to generate spatially periodic vascular clusters and inter-cluster hypoxic regions. These emergent patterns produce heterogeneous drug penetration and resistant niches. Our results identify TAF clearance, chemotactic sensitivity, and endothelial motility as effective levers to homogenize perfusion. The model is two-dimensional and employs simplified kinetics, and we outline necessary extensions to three dimensions and saturable kinetics required for quantitative calibration. The study links reaction–diffusion mechanisms with clinical principles and suggests actionable strategies to mitigate resistance by targeting endothelial–TAF feedback. Full article

Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant challenge, costing annually approximately USD 1.2 billion to the U.S. swine industry due to production losses associated with, but not limited to, reproductive failure, abortion, and high pre-weaning mortality among piglets. PRRSV is endemic, with thirty percent of the U.S. breeding herd experiencing outbreaks annually. The shedding status of animals on a farm is typically assessed using serum or processing fluids from piglets, but tongue tips from deceased animals are emerging as a potential alternative specimen to support farm stability assessment. This study explored the impact of various processing and testing strategies on tongue tips to enhance the sensitivity and specificity of PRRSV detection in sow herds. We collected tongue tips from 20 dead piglets across seven sow farms, testing different pooling strategies (individual testing, and pools of n = 5 or n = 20) and laboratory processing methods (tongue tip fluid—TTF, versus tongue tissue homogenate—TTH). Additionally, we simulated storage and shipping conditions, comparing frozen samples to refrigerated ones tested at intervals of 1, 4, and 7 days post collection. RT-PCR testing revealed higher sensitivity and lower cycle threshold (Ct) values for TTF compared to TTH, suggesting that tongue tips are better tested as TTF rather than TTH for PRRSV detection. Pooling samples reduced diagnostic accuracy. Frozen samples had lower absolute Ct values, and Ct values increased by 0.2 Ct values each day post collection when the sample was kept refrigerated, emphasizing the importance of minimizing shipping delays. Tongue tips are a practical, easy-to-collect specimen that target potentially infected animals (dead piglets), offering valuable insights into swine herd health, but sample processing approaches significantly influence diagnostic outcomes. If tongue tips are used by veterinarians to assess viral presence on a farm, testing the TTF instead of TTH should be prioritized. Storage and shipment conditions should be considered to optimize laboratory results. Full article

As the development of electric tractors progresses, battery systems have become a key component, accounting for a significant portion of the vehicle’s total weight. With rollover accidents remaining a leading cause of fatal injuries in agricultural machinery, the stability of electric tractors is drawing increasing attention. In particular, battery placement may critically affect the overall mass distribution and rollover behavior, highlighting the need for safety-focused design optimization. This study evaluates the static rollover stability of a 55 kW electric tractor by analyzing the effect of battery mounting position and comparing it with a conventional tractor. Three tractor models were considered: an electric tractor with a front-mounted battery, one with a center-mounted battery, and a conventional tractor. Multibody dynamic simulations were conducted using RecurDyn, and a total of 24 orientations, at 15° intervals, were simulated to determine the tipping angles in all directions. The results revealed that battery placement had a significant impact on rollover stability. The front-mounted battery type exhibited up to 30% higher tipping angles than the conventional tractor in the forward pitch direction near 90°, indicating improved stability. In contrast, the center-mounted battery type showed a tipping angle distribution generally similar to that of the conventional tractor, with smaller variations across directions. These findings demonstrate the influence of mass distribution on rollover safety and provide valuable insight for structural design of electric tractors. Full article

Current passive anti-rollover systems exhibit inadequate adaptability to complex operational environments. Additionally, due to unidentified critical factors driving rollover incidents during landing, the design of active anti-tipping systems for airdrop remains constrained. Given the foregoing circumstances, this paper divides the landing impact process of the vehicle into the airbag cushioning stage and the rigid collision stage. In the airbag cushioning stage, a vertical impact test bench and a fluid–structure interaction (FSI) model is built up to obtain the terminal impact velocity when the airbag’s touching down speed is set as around 8 m/s. An oblique impact test bench and a dynamic model are proposed to investigate the influence of terminal sideslip angles and impact velocities on the vehicle’s roll/pitch stability during the rigid collision phase. Experimental and numerical analyses reveal that the peak overload during the airbag cushioning stage reaches approximately 11 g while the terminal impact velocity in this stage is around 2 m/s. In the rigid collision stage, higher initial descent velocities amplify the peak roll angles and significantly compromise the roll stability. Notably, adjusting the terminal sideslip angle from 90° to 0°/180° triples the critical horizontal velocity threshold from 5.3 m/s to 14.7 m/s which markedly enhances the vehicle’s stability. To address this, an active sideslip angle control system activated at a 250 m altitude is developed to align the vehicle’s horizontal velocity vector with its longitudinal axis to nearly 0°/180° and thus improves the roll/pitch stability. This study establishes a technical foundation for the design of a highly reliable anti-rollover device for the airdrop vehicle. Full article

This study presents detailed microstructural observations of the mouthparts and sensory organs of adult cicadomorphan species, obtained using scanning electron microscopy (SEM). Despite microstructural variation, the overall morphology of the mouthparts, comprising a three-segmented labium and a bundle of interlocking stylets (maxillae and mandibles), is highly conserved across species, supporting its evolutionary significance in sap feeding from floem, xylem, or epidermis cells. Variations in the number and shape of mandibular stylet barbs likely reflect adaptations to different host plant tissues. The presence of an identical dual interlocking system between the maxillary stylets, which is found consistently across taxa, enhances functional stability during feeding and indicates a conserved mechanism among cicadomorphans. The species studied exhibit two distinct types of salivary canal closure: hooked and T-shaped. The latter potentially represents a state linked to specialised feeding strategies, such as sap xylem feeding. On the labial tip, there are different shapes of the anterior sensory fields. This area hosts a complex array of sensilla of different numbers, including gustatory (sensilla peg, PS1 and PS2, basiconica, BS3, double basiconica, DB), olfactory (finger–like, FLS) and thermo-hygroreceptive (sensillum dome-shaped, DS, and coeloconicum, CS) types, which facilitate host detection and feeding site selection. In the posterior sensory field, sensilla contact-chemosensory (sensilla basiconica, BS1 and BS2, and sensillum trichoideum, TS) are present. Mechanosensilla chaetica (CH1–CH3) are widely distributed on the last labial segment and may contribute to labium positioning. These findings emphasise the presence of both conserved and specialised morphological traits reflecting evolutionary and ecological diversification within Cicadomorpha. Full article

Currently, Japan’s fishing industry is facing a severe decline in its workforce. As a response, fishing mechanization using small underwater robots is promoted. These robots offer advantages due to their compact size, although their operating time is limited. A major source of this limited operating time is posture stabilization, which requires continuous thruster use and rapidly drains the battery. To reduce power consumption, anchoring the robot to the seabed with anchors is proposed. However, due to neutral buoyancy, the available thrust is limited, making penetration into the seabed difficult and reducing stability. To address this, we focus on composite-shaped anchors and vibration. The anchors combine a conical tip and a cylindrical shaft to achieve both penetrability and holding force. However, a trade-off exists between these functions depending on the tip angle; anchors with larger angles provide better holding capacity but lower penetrability. To overcome this limitation, vibration is applied to reduce soil resistance and facilitate anchor penetration. While vibration is known to aid penetration in saturated soft soils, the effect of tip angle under such conditions remains unclear. This study aims to clarify the optimal tip angle for achieving sufficient penetration and holding performance under vibratory conditions. Experiments in underwater saturated soft soil showed that vibration improves both penetration and holding. This effect was strong in anchors with tip angles optimized for holding force. These findings support the development of energy-efficient anchoring systems for autonomous underwater operations in soft seabed environments. Full article

In global cold regions and seasonal frozen soil areas, frost heave failure of rock slopes severely endangers infrastructure safety, particularly along China’s Sichuan–Tibet and Qinghai–Tibet Railways. To address this, a meshless numerical model based on the smoothed particle hydrodynamics (SPH) method was developed to simulate progressive frost heave and fracture of water-saturated fissured rock masses—its novelty lies in avoiding grid distortion and artificial crack path assumptions of FEM as well as complex parameter calibration of DEM by integrating the maximum tensile stress criterion (with a binary fracture marker for particle failure), thermodynamic phase change theory (classifying fissure water into water, ice-water mixed, and ice particles), and the equivalent thermal expansion coefficient method to quantify frost heave force. Systematic simulations of fissure parameters (inclination angle, length, number, and row number) revealed that these factors significantly shape failure modes: longer fissures and more rows shift failure from strip-like to tree-like/network-like, more fissures accelerate crack coalescence, and larger inclination angles converge stress to fissure tips. This study clarifies key mechanisms and provides a theoretical/numerical reference for cold region rock slope stability control. Full article

Water contamination by heavy metals, particularly lead, derived from industrialization, climate change, and urbanization, represents a critical risk to human health and the environment. Several agricultural biomass residues have demonstrated efficacy as contaminant adsorbents. In this context, the study aimed to evaluate the potential of sugarcane tip (ST) waste biomass treated by hydrothermal carbonization (HTC) to produce hydrochar as an adsorbent material for Pb²⁺ in aqueous solutions. Samples were synthesized from the waste biomass at temperatures of 180 °C, 215 °C, and 250 °C, with a constant pressure of 6 MPa. Aqueous solutions of Pb²⁺ were prepared at concentrations of 10, 25, 50, 75, and 100 mg/L. Each solution was stirred at 1 g of hydrochar at 150 rpm, 25 °C, and pH 5 for 15 to 120 min. The solutions were filtered and stored at 4 °C for flame atomic absorption spectrophotometry analysis. In all cases, equilibrium was reached rapidly—within 15 min or less—as indicated by the stabilization of q_t values over time. At an initial concentration of 100 mg L⁻¹, the highest equilibrium uptake was observed for the hydrochar synthesized at ST HTC 180 °C (4.90 mg g⁻¹), followed by 4.58 mg g⁻¹ and 4.52 mg g⁻¹ for ST HTC 215 °C and ST HTC 250 °C, respectively. For the ST HTC 180 °C, the Sips model provided the best correlation with the experimental data, exhibiting a high maximum capacity (q_max = 240.8 mg g⁻¹; K_s = 0.007; n = 1.09; R² = 0.975), which reinforces the heterogeneous nature of the material’s surface. Hydrothermal synthesis increased the amount of acidic active sites in the ST HTC 180 °C material from 1.3950 to 3.8543 meq g⁻¹, which may influence the electrical charge of the Pb²⁺ adsorption process. HTC-treated sugarcane tip biomass represents a promising alternative for the synthesis of adsorbent materials, contributing to water remediation and promoting the circular economy by sustainably utilizing agricultural waste. Full article