Search Results (2,210)

Introduction: Extrinsic skin damage is often a result of oxidative stress caused by exposure to environmental factors such as ultraviolet (UV) radiation, ozone (O₃), and various pollutants. As a result, topical antioxidants have been evaluated for their effectiveness in mitigating or reversing skin damage caused by environmental factors. Topical antioxidants containing a combination of l-ascorbic acid, tocopherol, and ferulic acid have significantly improved markers of skin health after exposure to environment-induced skin damage. However, research suggests that l-ascorbic acid and tocopherol tend to be relatively unstable, possibly affecting their efficacy against outdoor stressor damage. It has been shown that ferulic acid significantly improves the stability of both l-ascorbic acid and tocopherol, but its long-term stabilization effects on these antioxidants are relatively unknown. Material and Methods: This study evaluated the time-dependent effectiveness of a topical antioxidant mix containing 15% l-ascorbic acid, 1% tocopherol, and 0.5% ferulic acid (AOX) on UV-induced skin damage. Skin biopsies (12 mm, n = 60) were placed in a 6-well plate with medium and incubated at 37 °C and 5% CO₂ overnight. The day after, skin samples were pretreated with 10 µL of differently aged AOX (0-, 6-, 12-, and 36-month-old) and then exposed to different doses of UV light (100, 200, 400 mJ/cm²) daily over four days. AOX formulations were stored in a cool, dry, and dark place at approximately 20–22 °C during the whole study. This study evaluated 4-hydroxynonenal (4-HNE) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) as oxidative damage and skin DNA damage markers, Collagen1 and Filaggrin as skin structure, and IL-8 and Nrf2 as inflammatory and defensive response. Results: UV exposure significantly increased oxidative and inflammatory markers in human skin explants affecting also filaggrin and collagen levels. However, pre-treatment with the antioxidant formulation, particularly in its younger formulations (0-, 6-, and 12-month-old), significantly reduced the damaging effect of UV. Additionally, all antioxidant formulations effectively mitigated UV-induced damage across all doses. Conclusions: Our results indicate that pre-treatment with this formulation consistently reduces UV-induced oxidative damage and DNA damage in human skin explants, regardless of the formulation age and the discoloration state. Although effective, the protective capacity of aged formulations may be reduced only when extreme UV exposure is tested, a condition that is unlikely to occur under typical environmental conditions. These results support ferulic acid as a stabilization agent for topical antioxidant mixtures. Full article

Anticoagulant rodenticides (ARs) are highly effective, but can be of environmental concern due to primary and secondary non-target exposure, with the latter possible being relevant to domestic cats. Therefore, liver residues of ARs and an alternative rodenticide, α-chloralose, were systematically monitored in domestic cats for the first time in the current study. In 2021 and 2022, the carcasses of 99 cats were collected in Slovenia and liver residues were measured by using solid supported liquid–liquid extraction and LC-MS/MS. The results show that 65% of cats carried at least one rodenticide. The second-generation ARs brodifacoum and bromadiolone were most prevalent and found in 53.5 and 25.3% of the samples, respectively. Of first-generation ARs, coumatetralyl was the most prevalent (21.2% of cats). More compounds were detected at high human population density, low farm density and in rural versus intermediate landscapes, but no effect was found for livestock density. Similar trends were found for the presence of brodifacoum, bromadiolone and all rodenticides combined. Farm density was negatively correlated with brodifacoum liver concentration. Individual factors (cat age, sex, outdoor activity) did not matter. The results indicate that a reasonably populated rural landscape, and not the rural or intermediate environment as such, is the main driver of cat exposure to ARs. The risk quotient (RQ) of worst-case acute brodifacoum poisoning was 1506. In summary, a potential environmental problem is globally highlighted for cats that is probably related to secondary exposure to ARs, with a pattern different to that seen in wild predators. Cats are an appropriate sentinel species for assessing rodenticide exposure and endangerment in the environment. Full article

In recent years, radiology has become a key factor in sports clinical decision-making, primarily due to two parallel trends: the need for timely imaging in elite sports and the increase in recreational and weekend exercise-related injuries among individuals who adopt a healthy lifestyle, often in outdoor settings and without structured physical preparation [...] Full article

Most research on domestic dog (Canis familiaris) behavior has focused on pets with restricted movement. However, free-ranging dogs exist in diverse cultural contexts globally, and their interactions with humans are less understood. Tourists can facilitate unrestricted dog movement into wilderness areas, where they may negatively impact wildlife. This study investigated which stimuli—namely, voice, touch, or food—along with inherent factors (age, sex, sociability) motivate free-ranging dogs to follow a human stranger. We measured the distance (up to 600 m) of 129 free-ranging owned and stray dogs from three villages in southern Chile as they followed an experimenter who presented them one of the above stimuli or none (control). To evaluate the effect of dog sociability (i.e., positive versus stress-related or passive behaviors), we performed a 30 s socialization test (standing near the dog without interacting) before presenting a 10 s stimulus twice. We also tracked whether the dog was in the company of other dogs. Each focus dog was video-recorded and tested up to three times over five days. Generalized linear mixed-effects models revealed that the food stimulus significantly influenced dogs’ motivation to follow a stranger, as well as a high proportion of sociable behaviors directed towards humans and the company of other dogs present during the experiment. Juveniles tended to follow a stranger more than adults or seniors, but no effects were found for the dog’s sex, whether an owner was present, the repetition of trials, the location where the study was performed, or for individuals as a random variable. This research highlights that sociability as an inherent factor shapes dog–stranger interactions in free-ranging dogs when food is given. In the context of wildlife conservation, we recommend that managers promote awareness among local communities and tourists to avoid feeding dogs, especially in the context of outdoor activities close to wilderness. Full article

This study investigates the seasonal effectiveness of high-efficiency particulate air (HEPA) purifiers and window-opening behaviors in three London nurseries, using continuous indoor and outdoor PM_2.5 monitoring, window state and air purifier use, and occupant questionnaire data collected from March 2021 to February 2022. Of the approximately 40–50 nurseries contacted, only three agreed to participate. Results show that HEPA purifiers substantially reduced indoor particulate matter (PM_2.5), with the greatest effect observed during the heating season when windows remained closed for longer periods. Seasonal and behavioral analysis indicated more frequent and longer window opening in the non-heating season (windows were open 41.5% of the time on average, compared to 34.2% during the heating season) driven by both ventilation needs and heightened COVID-19 concerns. Predictive modeling identified indoor temperature as the main driver of window opening, while carbon dioxide (CO₂) had a limited effect. In addition, window opening often increased indoor PM_2.5 under prevailing outdoor air quality conditions, with mean concentrations rising from 2.73 µg/m³ (closed) to 3.45 µg/m³ (open), thus reducing the apparent benefit of air purifiers. These findings underscore the complex interplay between mechanical purification and occupant-controlled ventilation, highlighting the need to adapt indoor air quality (IAQ) strategies to both seasonal and behavioral factors in educational settings. Full article

Physical activity, particularly when practiced in natural settings, has well-established benefits for overall health, sleep, and body composition. These effects are especially important for postmenopausal women, although research specifically targeting this population remains limited. The study evaluated a 16-week multicomponent outdoor exercise program (cardiorespiratory, strength, balance, coordination, and flexibility training) in postmenopausal women, consisting of three 60 min sessions per week. Participants were non-randomly assigned to an experimental group (EG, n = 55) and a control group (CG, n = 20). Measurements were taken at baseline and after 16 weeks, including body composition, sleep (duration and quality), and connection with nature. No significant differences were observed between groups at baseline. After the intervention, the EG and CG presented significant differences (p ≤ 0.01) in the rates of change in body mass, fat mass (FM; −9.26% and −1.21%, respectively), and visceral fat level (VFL; −13.46 points and −3.80 points). These differences were also observed for the sleep fragmentation index (p ≤ 0.01), but not for connection with nature. A significant interaction effect (p < 0.01) of time × group was observed for %FM, VFL, and appendicular skeletal muscle mass. Exercise duration had an effect (p = 0.043) on participants’ personal and affective identification with nature, and the time × group × medication interaction significantly influenced sleep efficiency (p = 0.034). The exercise program proved effective in reducing total and central adiposity levels; however, it did not lead to improvements in sleep duration, sleep quality, or connection with nature. Full article

Winery wastewater (WWW), if released untreated, poses a serious environmental threat due to its high organic load. In this study, Chlorella vulgaris was cultivated in diluted WWW to assess its suitability as a culture medium. Two outdoor cultivation systems—a 270 L raceway and a 40 L bubble column—were operated over 33 days using synthetic medium (control) and WWW. A flow cytometry (FC) protocol was implemented to monitor key physiological parameters in near-real time, including cell concentration, membrane integrity, chlorophyll content, cell size, and internal complexity. At the end of cultivation, the bubble column yielded the highest cell concentrations: 2.85 × 10⁶ cells/mL (control) and 2.30 × 10⁶ cells/mL (WWW), though with lower proportions of intact cells (25% and 31%, respectively). Raceway cultures showed lower cell concentrations: 1.64 × 10⁶ (control) and 1.54 × 10⁶ cells/mL (WWW), but higher membrane integrity (76% and 36% for control and WWW cultures, respectively). On average, cells grown in the bubble column had a 22% larger radius than those in the raceway, favouring sedimentation. Heterotrophic cells were more abundant in WWW cultures, due to the presence of organic carbon, indicating its potential for use as animal feed. This study demonstrates that FC is a powerful, real-time tool for monitoring microalgae physiology and optimising cultivation in complex effluents like WWW. Full article

While surgical procedure has been considered as the golden standard treatment for spasmodic entropion, Botulinum Neurotoxin A can be indicated in the treatment of spasmodic entropion for fragile elderly patients. This retrospective cohort study included 50 outdoor patients treated for spasmodic entropion, for whom palpebral surgery was recused. The intent of the present study was to describe an alternative outdoor treatment, to detail precisely the Botulinum Neurotoxin (BoNT) treatment pattern, the dosage of BoNT needed, the frequency of re-injection, the efficiency and the complications encountered. Fifty patients, 87.9 years old in average (±14.3) have been injected with BoNT. The average total dosage of BoNT is 7.62 ± 1.38 units of Incobotulinum, 10.2 ± 1.03 units of Onabotulinum and 17.2 ± 1.33 Speywood-units of Abobotulinum. Spasmodic entropion resolved in 3 ± 2 days after the BT injection. The average for re-injection is every 4.25 ± 1.30 months. By adjusting age and total dose, we have not been able to show any statistically significant relationship between time needed for re-injection and type of botulinum toxin A (p = 0.59). Patients with spasmodic entropion have responded significantly to BoNT injection. No systemic complications have been reported in this study. BoNT treatment is safe and effective for fragile elderly patients with spasmodic entropion and can be proposed instead of surgery or while waiting for their procedure. Full article

Thermal resilience is critical for building safety in cold climates during heating outages. This study presents full-scale experimental data from two residential buildings in Poland, tested during the winter of 2024–2025 under both typical and extreme outdoor conditions. The buildings—a lightweight timber-frame structure and a mediumweight masonry structure with ground coupling—were exposed to multi-day heating blackouts, and their thermal responses were monitored at a high temporal resolution. Several resilience indicators were used, including the resistance time (RT), degree of disruption (DoD), and hours of safety threshold (HST). Additionally, two time-based metrics—the time to threshold (T_x) and temperature at X-hours (T(t_x))—were introduced to improve classification in long-duration scenarios. The weighted unmet thermal performance (WUMTP) index was also implemented and validated using experimental data. The results show that thermal mass and ground coupling significantly improved passive resilience, enabling the mediumweight building to maintain temperatures above 15 °C for over 60 h without heating. This study provides new empirical evidence of passive survivability in blackout conditions and supports the development of time-sensitive assessment tools for cold climates. The findings may inform future updates to building codes and retrofit guidelines. Full article

Background: Considering the critical role of physical activity (PA) beginning in early childhood education and the demonstrated validity and reliability of contemporary technological measurement tools, this paper aimed to systematically review and analyze studies comparing PA levels in preschool-aged children during weekdays versus weekend days, using objective technological devices, and highlight what factors correlate with children’s PA. Methods: The search strategy was designed based on the PICOS framework. A systematic review was conducted using two databases (PubMed and Web of Science) to identify studies that included preschool children doing PA during weekdays, measured through technological devices, and compared to PA during weekend days. Study quality was evaluated using the MINORS scale. Results: From 1959 articles, 30 documents met the inclusion criteria, encompassing 32,251 preschool children. Conclusions: The results suggest that preschoolers were generally more active on weekdays than weekends, although it could depend more on contextual or individual factors than on the day of the week. In this sense, parental/maternal behavior (sedentary behavior, shared activities during weekend days, parents’ educational level, and parental/maternal screen time) influences children’s PA level, as well as other factors such as gender, morphology, motor competence level, the type of activity (indoor vs. outdoor), age, meeting PA guidelines, and the community transportation environment. Considering these factors, professionals working in preschools or kindergartens, as well as parents/mothers, should consider these factors to foster children’s PA level from early childhood, which could influence children’s lifespan. Full article

Building-integrated photovoltaic (BIPV) windows present a viable path towards carbon neutrality in the building sector. However, conventional BIPV windows, such as semi-transparent photovoltaic (STPV) glazings, still suffer from inadequate thermal insulation, which limits their effectiveness across different climate conditions. To address this issue, the cadmium telluride-based vacuum PV glazing has been developed to enhance the thermal performance of BIPV applications. To fully understand the complex thermal behaviour under real-world operational scenarios, this study introduces a one-dimensional transient heat transfer model that can efficiently capture the time-dependent thermal dynamics of this novel glazing system. Based on the numerical solutions using the explicit finite difference method (FDM), the temperature profile of the vacuum PV glazing can be obtained dynamically. Consequently, the heat gain of the semi-transparent vacuum PV glazing can be calculated under time-varying outdoor and indoor conditions. The validated heat transfer model was applied under four different scenarios, viz. summer daytime, summer nighttime, winter daytime, and winter nighttime, to provide a detailed analysis of the dynamic thermal behaviour, including the temperature variation and the energy flow. The dynamic thermal characteristics of the vacuum PV glazing calculated by the transient heat transfer model demonstrate its excellent thermal insulation and solar control capabilities. Moreover, the thermal performance of vacuum PV glazing was compared with a standard double-pane window under various weather conditions of a typical summer day and a typical winter day. The results indicate that the vacuum PV glazing can effectively minimise both heat gain and heat loss. The fluctuation of the inner surface temperature can be controlled within a limited range away from the set point of the indoor room temperature. Therefore, the vacuum PV glazing contributes to stabilising the temperature of the indoor environment despite the fluctuating solar radiation and periodic outdoor temperature. It is suggested that the vacuum PV glazing has the potential to enhance the climate adaptability of BIPV windows under different climate backgrounds. Full article

We present a lightweight autonomous driving method that uses a low-cost camera, a simple end-to-end convolutional neural network architecture, and smoother driving techniques to achieve energy-efficient vehicle control. Instead of directly constructing a mapping from raw sensory input to the action, our network takes the frame-to-frame visual difference as one of the crucial inputs to produce control commands, including the steering angle and the speed value at each time step. This choice of input allows highlighting the most relevant parts on raw image pairs to decrease the unnecessary visual complexity caused by different road and weather conditions. Additionally, our network achieves the prediction of the vehicle’s upcoming control commands by incorporating a view synthesis component into the model. The view synthesis, as an auxiliary task, aims to infer a novel view for the future from the historical environment transformation cue. By combining both the current and upcoming control commands, our framework achieves driving smoothness, which is highly associated with energy efficiency. We perform experiments on benchmarks to evaluate the reliability under different driving conditions in terms of control accuracy. We deploy a mobile robot outdoors to evaluate the power consumption of different control policies. The quantitative results demonstrate that our method can achieve energy efficiency in the real world. Full article

Increasing temperatures associated with climate change will lead to (periodic) temperature-induced reductions in food intake in human and other mammal populations. Human adults, however, are both tolerant and resilient to periodic nutritional deficits, and the associated health effects should be limited. Intermittent nutritional deficits may also cause growth restriction in developing foetuses and young children, which potentially affects their food intake in later life. Therefore, temperature-induced hypophagia can be hypothesised to manifest as later compensatory responses with multiple concomitant (or extended) lags of varying temporal dimensions. We examined the relationship between calorie intake and ambient outdoor temperatures for a time series covering past decades (FAO data for 1961–2013) in 80 countries to determine if humans alter their food intake in response to elevated temperatures. We included eleven different temporal “windows of exposure” of varying lag. These windows considered current and recent exposure, just as lagged effects allowed for a consideration of past effects on mothers, their children, and childhood exposure. It was hypothesised that one of these could provide a basis for predicting future changes in human calorie intake in response to climate change. Our analyses showed no apparent association with temperatures in ten of the eleven hypotheses/models. The remaining hypothesis suggests that current calorie intake is linked to decadal mean temperatures with a lag of approximately three decades, pointing to an impact on mothers and their (developing) children. The impact of an increase in mean temperature varies with temperature amplitudes, and negative impacts are only found in countries with low temperature amplitudes (warmer countries), albeit the impact on calorie intake caused by a 2–3 °C change in temperatures or temperature amplitudes is generally modest. However, in considering calorie intake, we only address quantities of food (with unspecified quality), which insufficiently reflect the full range of nutritional challenges associated with increasing temperatures. Understanding climate-driven changes in human food intake requires global interdisciplinary collaboration across public health, environmental science, and policy. Full article

The superhydrophobic coatings for outdoor use need to be exposed to sunlight for a long time; therefore, their UV-aging resistances are crucial in practical applications. In this study, the primary product of titanium dioxide (P-TiO₂) was used as the raw material. Nano-silica (SiO₂) was coated onto the surface of P-TiO₂ by the acid precipitation method to prepare P-TiO₂-SiO₂ composite particles. Then, they were modified and sprayed simply to obtain a superhydrophobic P-TiO₂-SiO₂/HDTMS coating. The results indicated that amorphous nano-SiO₂ was coated on the P-TiO₂ surface, forming a micro–nano binary structure, which was the essential structure to form superhydrophobic coatings. Additionally, the UV-aging property of P-TiO₂ was significantly enhanced after being coated with SiO₂. After continuous UV irradiation for 30 days, the color difference (ΔE*) and yellowing index (Δb*) values of the coating prepared with P-TiO₂-SiO₂ increased from 0 to 0.75 and 0.23, respectively. In contrast, the ΔE* and Δb* of the coating prepared with P-TiO₂ increased from 0 to 1.68 and 0.74, respectively. It was clear that the yellowing degree of the P-TiO₂-SiO₂ coating was lower than that of P-TiO₂, and its UV-aging resistance was significantly improved. After modification with HDTMS, the P-TiO₂-SiO₂ coating formed a superhydrophobic P-TiO₂-SiO₂/HDTMS coating. The water contact angle (WCA) and water slide angle (WSA) on the surface of the coating were 154.9° and 1.3°, respectively. Furthermore, the coating demonstrated excellent UV-aging resistance. After continuous UV irradiation for 45 days, the WCA on the coating surface remained above 150°. Under the same conditions, the WCAs of the P-TiO₂/HDTMS coating decreased from more than 150° to 15.3°. This indicated that the retention of surface hydrophobicity of the P-TiO₂-SiO₂/HDTMS coating was longer than that of P-TiO₂/HDTMS, and the P-TiO₂-SiO₂/HDTMS coating’s UV-aging resistance was greater. The superhydrophobic P-TiO₂-SiO₂/HDTMS self-cleaning coating reported in this study exhibited outstanding UV-aging resistance, and it had the potential for long-term outdoor use. Full article

In this paper, we investigate the target-approaching control problem for a discrete-time first-order vehicle system where the target area is modeled as a static circular region. In the absence of absolute bearing or position information, we propose a simple local controller that relies solely on range measurements to the target obtained at two consecutive sampling instants. Specifically, if the measured distance decreases between two successive samples, the vehicle maintains a constant velocity; otherwise, it rotates its velocity vector by an angle of $\pi /2$ in the clockwise direction. This control strategy guarantees convergence to the target region, ensuring that the vehicle’s velocity direction remains unchanged in the best-case scenario and is adjusted at most three times in the worst case. The effectiveness of the proposed method is theoretically established and further validated through outdoor experiments with a mobile vehicle. Full article