Search Results (575)

Background and Objectives: Anterior cruciate ligament (ACL) injury rates remain high and have a significant impact on female football players. This study aims to evaluate knee kinematics and lower limb muscle activity in players at risk of ACL injury compared to healthy players through three side-cutting tests. It also investigates how the amplitude of a change in direction influences stabilization parameters. Materials and Methods: A cross-sectional case–control study was conducted with 16 second division female futsal players (23.93 ± 5.16 years), divided into injured (n = 8) and healthy groups (n = 8). Injured players had a history of non-contact knee injury involving valgus collapse, without undergoing surgical intervention. Three change of direction tests, namely the Change of Direction and Acceleration Test (CODAT), Go Back (GOB) test, and Turn (TURN) test, were used for evaluation. The peak and range of knee joint angles and angular velocities across three planes, along with the average rectified and peak envelope EMG signals of the Biceps Femoris (BF), Semitendinosus (ST), Vastus Medialis (VM), and Lateral Gastrocnemius (LG), were recorded during the preparation and load phases. Group differences were analyzed using two-factor mixed-model ANOVA with pairwise comparisons. Statistical significance was set at p < 0.05. Results: Injured players demonstrated lower external tibial rotation angular velocity and a greater range of motion in tibial external rotation compared to healthy players. Additionally, the injured group showed significantly higher average rectified muscle activity in VM and LG both increased by 4% during the load phase. The CODAT and TURN tests elicited higher BF and VM muscle activity, compared to the GOB test. The TURN test also showed greater extension angular velocity in the sagittal plane. Conclusions: The results revealed differences in knee kinematics and muscle activity between players at risk of ACL injury and healthy players, influenced by the amplitude of directional changes. Players altered transverse plane mechanics and increased VM and LG activation during LOAD may reflect a dysfunctional motor pattern, while the greater sagittal plane angular velocity and VM and BF activation from the CODAT and the TURN test highlight their higher potential to replicate ACL injury mechanisms compared to the GOB test. Full article

Background/Objectives: The present study aimed to examine the branching pattern images of the Hepatis Portae Vena (HPV), which is one of the vascular structures of the liver, with Computed Tomography (CT), and to uncover the surgical and radiological importance of the variations. Methods: The HPV branching patterns on CT images of healthy liver of 996 individuals (47.8% male, 52.2% female) between the ages of 20 and 59 were evaluated according to previously determined definitions. The division of the main branch of the HPV into ramus (r.), dexter, and r. sinister and the later division of r. dexter into r. anterior and r. posterior branches were called Type I-a, other main branch variations were called Type II-a, Type III-a, and Type IV-a, and the r. dexter variations were called Type V-b, Type VI-b, Type VII-b, and Type VIII-b. Also, all individuals in the present study were examined under four age groups as 20–29, 30–39, 40–49, 50–59, and the data were analyzed in the SPSS 21 software. Results: Type I-a (73.1%) was detected most frequently in all individuals, but Type VI-b (0.1%) and Type VII-b (0.1%) were detected least frequently. Following Type I-a, Type II-a (10.6%), Type III-a (8.2%), and Type V-b (5.5%) were detected, respectively. No statistically significant differences were detected between gender and age groups in terms of the frequency of HPV types (p > 0.05). Conclusions: We believe that accurate knowledge and definition of HPV anatomy will guide liver surgeries and interventional radiology, which are the cornerstones of the treatment of liver diseases. Full article

Background: We studied in silico models of both organic and inorganic substances. In most cases, these in silico models are used for organic substances only. The following endpoints were taken for the case studies: the octanol–water coefficient (three models), the enthalpies of formation of organometallic compounds, and rat acute toxicity. Methods: The correlation weights were optimized using the Monte Carlo method with two special training and validation sets. The training set was structured into three subsets of active and passive training, as well as a calibration set. The division into these four subsets was carried out using the Las Vegas algorithm. It is assumed that considering groups of different splits into these four subsets is more informative than considering only a single split. Results: Models were built for the octanol–water coefficient for a set containing organic and inorganic substances or for a subset of the original data; other models were developed for a set containing only specially defined inorganic substances for platinum complexes. In addition, models of the enthalpy of formation and for toxicity in rats were built using the same approach for two sets of inorganic substances. Conclusions: A comparison of different methods for the optimization of correlation weights using the Monte Carlo method showed that optimization can be improved using the coefficient of conformism of a correlative prediction (CCCP) or the index of the ideality of correlation (IIC). Optimization with CCCP was the best option for the models of the octanol–water partition coefficient for the set of organic compounds, the octanol–water partition coefficient of the inorganic set, and the enthalpy of formation of the inorganic compounds. However, optimization with IIC was the best option in terms of the toxicity of the inorganic compounds in rats. Full article

Background and Objective: Due to the increasing use of imaging and lung cancer screening programs, the rate of detected pulmonary nodules has steadily increased over the past decade. Overall, the diagnosis and management of pulmonary nodules remain challenging. Moreover, no specific guidelines exist for the management of pulmonary nodules in patients with a history of previous malignancy. This study reflects the current management in a real-world setting in a specialized European center. Methods: In this retrospective single-center study, patients with a pulmonary nodule <3 cm referred to the Division of Pulmonology or the Department of Thoracic Surgery at the Medical University of Vienna, Austria, from November 2022 to July 2024, were analyzed. A subgroup analysis of patients with a history of previous malignancy was performed and compared to patients without previous malignancies. Results: In total, 356 patients (48.5% male, median age 67 years [IQR 61–74], 53.7% with a history of previous cancer) with a pulmonary nodule (mean size of 14.8 mm) were enrolled. Bronchoscopy, computed tomography (CT)-guided biopsy, or surgery was performed in 13.2%, 7.3%, and 65.2% of the cases, respectively. The overall malignancy rate was 70.5%. Pulmonary nodules in patients with a prior malignancy were significantly larger (p < 0.001), showed a progression in size (p < 0.001), and were found to be malignant more frequently when compared to patients without previous cancer (p = 0.032). Conclusions: As most patients referred to a specialized center represent a selected group of high-risk patients, the majority of pulmonary nodules were found to be malignant. In patients with a history of previous malignancy, tissue sampling is warranted as the rate of malignancy is high. Full article

Background and Objectives: Vision uses about half of the pathways within the brain, and these anatomical structures are susceptible to injury in concussion. Authors have suggested that subconcussive head impacts, common in soccer, may disrupt visual function. The following study aimed to explore and compare quantitative pupillometry and Vestibular Ocular Motor Screening (VOMS) in female soccer athletes. Materials and Methods: Twenty-six Division 1 female soccer athletes (20.46 ± 2.36 years) received baseline quantitative pupillometry and VOMS measurements. Results: Of the 26 tested athletes, 3 (11.5%) had clinically significant pupillometry findings at baseline. The mean Neurological Pupil Index or NPi, a composite generated from pupillometry, did not vary: 3.9 ± 0.4 (right eye) and 4.0 ± 0.4 (left eye). No difference in NPi was observed compared to the VOMS score (p > 0.05). Kruskal–Wallis H tests were significant in the right eye for constriction percentage (χ²(2) = 17.843, p < 0.001, E² = 0.69) and minimum pupil size (χ²(2) = 7.976, p = 0.019, E² = 0.31). A post hoc Dunn test showed significant differences in constriction percentage and minimum pupil size between low NPi and high NPi groups (p < 0.05). One athlete sustained a concussion. NPi was measured within 24 h and was normal, but VOMS was not (total score = 4). Conclusions: The components of pupillometry need more investigation, and there is a need for agreement on concussion-specific cutoffs for quantitative pupillometry for concussion assessment. The lack of a relationship between quantitative pupillometry and VOMS suggests that these tools evaluate different constructs. Athletes with an NPi < 3.8 had significantly less constriction percentage and larger minimum pupil size than athletes with higher NPi scores. More research should be carried out to determine the usefulness of the NPi score, and perhaps researchers should consider individual pupillometry components. Full article

This study employs text mining techniques to conduct a systematic quantitative analysis of cybersecurity-related scientific publications and technological research. It aims to break through the limitations of traditional unidirectional evolutionary research, reveal the knowledge evolution rules between scientific theories and technical practices in this field, and provide valuable references and decision-making support for optimizing the collaborative innovation ecosystem. Firstly, we took academic papers and patent research on cybersecurity from 2005 to 2024 as the research objects and divided them into ten stages according to the time series. Subsequently, we identified scientific and technological topics and formed science–technology topics to assess their similarity. Then, we selected 3040 pairs of collaborative topic pairs and categorized them into three distinct groups: weak, moderate, and strong correlation. Finally, we constructed a science–technology topic association evolution atlas and analyzed the types of evolutionary pathways of topic associations and their mechanisms of action accordingly. The results demonstrate five evolutionary patterns in science–technology topic associations: division, merging, inheritance, co-occurrence, and independent development. Additionally, the science–technology topics demonstrate a high degree of collaboration, exhibiting a collaborative effect of “initial accumulation–fluctuating differentiation–deep collaboration”. Meanwhile, the correlation evolution of strongly related science–technology topics presents a symmetrical effect of “technology–science–technology” and “science–technology/technology–science”. Full article

Background/Objectives: Routinely, clinicians planning the mechanics of orthodontic treatment for their patients do not take into account the inclinations of canine and lateral teeth. This is due to a lack of solid evidence in the area. Additionally, sound data is lacking on differences between tooth inclinations in patients presenting class II, subdivision 1 and class II, subdivision 2 relationships. This study is meant to investigate this matter. Methods: To conduct this study, cephalograms of 83 patients scheduled for orthodontic treatment were retrospectively selected from the records of the Department of Orthodontics at Wroclaw Medical University and analyzed. Patients were divided into three groups (class I, class II subdivision 1, class II subdivision 2). Inclinations of the long axes of canine and lateral teeth were measured in relation to the palatal plane. Results: We established that there exist statistically significant differences in inclination for some of the teeth assessed. Conclusions: Multiple correlations were found between tooth inclination and some cephalometric measurements, particularly the SNB angle. The canines and upper premolars undergo a natural distal tilt to compensate for the mandible’s retruded position. Clinicians planning treatment for skeletal class II patients should formulate treatment plans involving the distal tipping of lateral teeth with great care, as such patients may already exhibit distal inclinations of the lateral teeth. Patients with skeletal class II, division 2 may present greater demands in terms of proper orthodontic treatment mechanics compared to class II, division 1 patients. Full article

Background/Objectives: A previous study evaluating convex facial profiles at rest demonstrated that combined orthodontic and orthognathic surgical treatment is more effective in enhancing facial aesthetics compared to orthodontic camouflage alone. The present follow-up study aimed to reassess these findings by incorporating both profile and frontal facial views in the aesthetic evaluation. Methods: This retrospective cohort study sample included 36 consecutively selected patients with convex facial profiles and Class II Division 1 malocclusion. Two groups of 18 non-growing patients with similar characteristics were compared. Group A was treated with orthodontics and orthognathic surgery, whereas Group B was treated with orthodontics exclusively. Pre- and post-treatment profile and frontal facial photographs were simultaneously presented to orthodontists, oral and maxillofacial surgeons, convex profile patients, and laypeople, asking them to assess changes in facial appearance. Results: Significant positive changes in facial appearance were perceived for Group A, in contrast to no changes for Group B, with a difference of 17/100 visual analogue scale (VAS) units. The rater groups demonstrated a high degree of consistency (ICC > 0.88). Multivariate analysis revealed significant differences in perceived changes between the two treatment groups (F = 14.63, p < 0.001, Pillai’s Trace = 0.36, and partial η² = 0.36), with no significant effects from the rater group (p > 0.05). Similar results are evident when only profile photos were rated (p > 0.05). Conclusions: The combined orthodontic and orthognathic surgery approach effectively enhances facial appearance in convex profile cases, whereas orthodontic treatment alone does not result in significant changes. These findings should be clearly communicated during patient consultations and considered in treatment planning. Full article

We studied the Japanese dialect by calculating aggregated PMI Levenshtein distances among local Japanese dialects using data from 2400 locations and 141 items from the Linguistic Atlas of Japan Database (LAJDB). Through factor analysis, we found the latent linguistic variables underlying the aggregated distances. We found two factors, the first of which reflects a division into five groups, and the second of which reflects the long-standing East/West cultural contrast in mainland Japan, also known as the AB division. In the latter division, the eastern group includes the Okinawa islands. We paid special attention to the Tokyo dialect, which is associated with Standard Japanese. In a second factor analysis, only distances to the Tokyo dialect were considered. Although the patterns represented by the four factors vary, they consistently show that dialects geographically closer to Tokyo are more similar to the Tokyo dialect. Additionally, the first three factors reflected the similarity of the Hokkaido varieties to Tokyo’s local dialect. The results of the factor analyses were linked back to the individual variation patterns of the 141 items. A more precise analysis of Tokyo’s position within the Japanese dialect continuum revealed that it is situated within a region of local dialects characterized by relatively small average linguistic distances to other dialects. This area includes the more central area of mainland Japan and Hokkaido. When the influence of geographical distance is filtered out, only the local dialects of Hokkaido remain as dialects with the smallest average distance to other local dialects. Additionally, we observed that dialects geographically close to Tokyo are most closely related to it. However, when we again use distances that are controlled for geographical distance, the local dialects on Hokkaido stand out as being very related to the Tokyo dialect. This probably indicates that the Tokyo dialect has had a relatively large influence on Hokkaido. Full article

Antimicrobial resistance (AMR) is a critical public health issue in Bangladesh, where antibiotic use is widespread but often unregulated. This nationwide cross-sectional study (2017–2020) analyzed data from 26 public and private laboratories across all divisions of the country. Standardized data on antimicrobial susceptibility testing (AST) were collected, curated, and analyzed using WHONET, QAAPT, and R software to assess resistance patterns in 232,329 bacterial isolates from various clinical specimens. Escherichia coli was the most common pathogen (32.5%), followed by Klebsiella sp. (15.5%) and Pseudomonas sp. (10.6%). Urine specimens comprised 50.3% of the tested samples, while blood and soft tissue/body fluids accounted for 12.1% and 24.8%, respectively. Patients aged 55 years and older represented the largest group (36.3%), highlighting their vulnerability to drug-resistant infections. Resistance to third-generation cephalosporins was alarmingly high in Escherichia coli (62.9% resistant to ceftriaxone), whereas carbapenem resistance remained relatively low (5.3% and 6.8% to imipenem and meropenem, respectively). Klebsiella sp. showed widespread resistance, though carbapenems remained relatively effective (imipenem resistance 20.3%, meropenem 21.7%). In contrast, Salmonella sp. remained largely sensitive to third-generation cephalosporins. However, 42% of Staphylococcus aureus isolates were methicillin-resistant (MRSA). This study underscores the urgent need for improved antibiotic stewardship, enhanced diagnostic capacity, and strengthened AMR surveillance to preserve treatment options in Bangladesh. Full article

This scoping review examines the state of academic knowledge around gender and its role in Indigenous/traditional knowledge for food sustainability in Tonga, Samoa, Solomon Islands and Fiji. The different roles played by all genders—men, women and non-binary—in the Pacific Islands can contribute to climate adaptation and knowledge preservation for sustainable food production. The gender lens is especially relevant given the fact that women’s knowledge has, in recent years, been disregarded and marginalised as a consequence of colonial influences and increasing reliance on imported foods. We analysed 14 studies published in English between 2015 and 2024—six from refereed journal articles and eight from grey literature. Three themes emerged linking agriculture, gender and traditional knowledge, as follows: (1) there is a gendered division of labour and culturally defined roles between women and men, although the roles played by non-binary groups remain unclear; (2) intergenerational traditional knowledge transmission has declined; (3) climate change adaptation could be reinforced through passing on traditional knowledge. The findings demonstrate that gendered knowledge is distinct and complementary, and this knowledge should be integrated into Pacific agricultural production to achieve resilient and sustainable farming in the face of climate change. Full article

Chromosomal instability in Alzheimer’s disease (AD) neurons has been previously reported. This pilot study aimed to establish a quantitative technique for assessing X chromosome centromere signals using fluorescence in situ hybridization (FISH). Hippocampal brain tissue was collected at autopsy from sporadic AD patients and age- and gender-matched controls. FISH was utilized to detect and measure the intensity of hybridization signals for X chromosome centromeres in the interphase nuclei of hippocampal brain cells. The premature centromere division (PCD) phenomenon, marked by a close bipartite signal appearing as two separated FISH spots, was examined to see if the hybridized DNA amount in each spot matched the expected centromere DNA amount. The technique effectively distinguished between PCD+ and PCD− signals. The average PCD frequency of the X chromosome in the AD group was 7 ± 1%, compared with 3.2 ± 0.84% in the controls. This quantitative approach supports qualitative analyses of FISH centromere spots, reinforcing findings of chromosomal instability in AD. The presence of a double signal at the centromere of a single X chromosome indicates re-entered cell cycles, DNA replication, and PCD in hippocampal neurons. This technique provides a reliable method for identifying PCD + signals and contributes to understanding chromosomal instability in AD. Full article

Background: To the best of the authors’ knowledge, the different injury mechanisms of the hamstring muscle group have not been defined in detail in men’s professional football. For this reason, the main aim of this study is to determine the mechanisms and contextual patterns associated with hamstring muscle group injuries in professional male football players in competition, using a systematic video analysis method. Methods: Video recordings of official matches from two consecutive seasons (2017/18 and 2018/19) of the Spanish First Division of Football (LaLiga^TM) were used for this research. The process to determine the moment of injury was carried out by two independent evaluators using an ad hoc observation tool and, subsequently, all relevant data were collected to detail the specific patterns of injury events observed. Results: In total, 78 cases of hamstring injuries were included for the final analysis of specific patterns. The most outstanding results were that, (1) although the sprint-related pattern (SP) is predominate (54%; 42 cases), the combined pattern 2 (COMB2) is another mechanism that appears frequently (26%; 20 cases), (2) within the SP, curved runs show a greater number of cases (52% of SP; 22 cases), (3) the majority of the injuries occur without contact (83%; 65 cases) and with the presence of the ball (88%; 69 cases), and finally, (4) the most injured positions were fullbacks/wingbacks (28%; 22 cases), central defenders (27%; 21 cases), and wingers/wide midfielders (23%; 18 cases). Conclusions: The SP remains the most frequent pattern in hamstring injuries; however, the present study presents other mechanisms that are also quite common and should be considered, such as curvilinear runs in SP and COMB2. Full article

The pleuromutilin derivative, the compound PL-W, was synthesized by introducing a 4-fluorophenyl group at the C21 position and selected for comprehensive antibacterial evaluation. PL-W demonstrated notable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.03125 µg/mL, which is significantly lower than that of tiamulin (0.5 µg/mL). Crystal violet (CV) staining revealed that it inhibited MRSA biofilm formation and electron microscopy revealed that it disrupted bacterial cell division and, possibly, the synthesis of essential cell wall proteins. In both in vivo models, PL-W exhibited excellent performance. In the Galleria mellonella infection model, treatment with different concentrations of PL-W increased the survival rate from 20% to 90% and significantly reduced the bacterial load. In the mouse model of MRSA pneumonia, a 10 mg/kg dose of PL-W increased the survival rate to 70%, decreased the bacterial load in the lungs, and alleviated inflammatory damage. Molecular docking studies indicated that PL-W had a similar docking pose and comparable binding affinity to that of lefamulin, with hydrogen bond interactions that are crucial for binding to the peptidyl transferase center (PTC). Moreover, it demonstrated no significant reduction in cell viability in HepG2 and HEK293 cells, even at high concentrations (≤50 µg/mL). Overall, PL-W shows significant potential as a novel anti-MRSA agent owing to its potent in vitro and in vivo activities and low cytotoxicity. Full article

The rapid urbanization of the world has brought significant environmental, social, and economic challenges to human society. To build a sustainable county, there are many limiting factors, such as the environment, financial resources, and population. Based on this, the purpose of this study is to investigate how countries can empower their development through a sustainable design path for parks with the participation of all. The core of public participation in co-construction lies in the interactive relationship between the government, society, citizens, and many other groups. That is, “co-construction, co-governance, and sharing” is the basic content of the new pattern of social governance from the perspective of the park city; at its core is joint participation, division of labor, and cooperation. Using qualitative research methods, Kaiyuan, a county in Yunnan Province, was selected as a case study, focusing on the Phoenix Ecological Park and Happiness Lawn; citizens and managers were interviewed to explore paths for sustainable design in the counties. The contribution of this study is a research model of sustainable design for county parks with the participation of all the people. The study found that public participation should consider multiple co-constructions and formulate a sound sustainable design path from three dimensions: counties, managers, and citizens. Combined with the local characteristics of counties, the government has called on enterprises, organizations, and citizens to participate together in improving the quality of life and happiness of county residents. The results can be further verified in other counties. Full article