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23 pages, 5185 KiB  
Article
Comparative Analysis of the NorSand and HS Small Constitutive Models for Evaluating Static Liquefaction in a Silt Derived from Mine Tailings
by Matias Muñoz-Gaete, Ricardo Gallardo, Edison Atencio, Ricardo Moffat, Pablo F. Parra, Carlos Cacciuttolo and William Araujo
Appl. Sci. 2025, 15(15), 8726; https://doi.org/10.3390/app15158726 (registering DOI) - 7 Aug 2025
Abstract
The representation and assessment of static liquefaction in mine tailings is a significant challenge due to the severe environmental and social damage it can cause. This phenomenon, known for its catastrophic nature, is triggered when the undrained shear strength is exceeded by a [...] Read more.
The representation and assessment of static liquefaction in mine tailings is a significant challenge due to the severe environmental and social damage it can cause. This phenomenon, known for its catastrophic nature, is triggered when the undrained shear strength is exceeded by a static loading stress. In this study, the constitutive models HSS and NS were evaluated to calibrate the experimental curves from an isotropically consolidated undrained (CIU) triaxial test on a low-plasticity silt derived from mine tailings. An axisymmetric model was developed in Plaxis 2D for calibration, followed by a sensitivity analysis of the parameters of both constitutive models, using the RMSE to validate their accuracy. The results indicate that the proposed methodology adequately simulates the experimental curves, achieving an RMSE of 8%. After calibration, a numerical model was implemented to evaluate the propagation of the PFS of a mine tailings storage facility using both models, in terms of excess pore pressures, shear strains, and p’-q diagrams at three control points. The results show that both models are capable of representing the PFS; however, the HSS model reproduces the experimental curves more accurately, establishing itself as an ideal tool for simulating undrained behavior and, consequently, the phenomenon of static liquefaction in mine tailings. Full article
(This article belongs to the Special Issue Mining Engineering: Present and Future Prospectives)
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20 pages, 1729 KiB  
Article
Melatonin During Pre-Maturation and Its Effects on Bovine Oocyte Competence
by Laryssa Ketelyn Lima Pimenta, Nayara Ribeiro Kussano, José Eduardo Vieira Chaves, Hallya Beatriz Sousa Amaral, Maurício Machaim Franco, José Felipe Warmling Sprícigo and Margot Alves Nunes Dode
Antioxidants 2025, 14(8), 969; https://doi.org/10.3390/antiox14080969 (registering DOI) - 7 Aug 2025
Abstract
To minimize the deleterious effects of oxidative stress and improve oocyte competence, we assessed the impact of melatonin during in vitro pre-maturation (pre-IVM) in bovine cumulus–oocyte complexes (COCs). We compared three groups: control (conventional IVM), pre-IVM control (without melatonin), and pre-IVM + MTn [...] Read more.
To minimize the deleterious effects of oxidative stress and improve oocyte competence, we assessed the impact of melatonin during in vitro pre-maturation (pre-IVM) in bovine cumulus–oocyte complexes (COCs). We compared three groups: control (conventional IVM), pre-IVM control (without melatonin), and pre-IVM + MTn (with melatonin). The analyses included levels of reactive oxygen species (ROS), mitochondrial activity, oocyte lipid content, and the expression of genes related to oxidative stress and lipid metabolism in oocytes and cumulus cells. We also examined embryo quality by evaluating kinetics of development and gene expression. The pre-IVM + MTn group exhibited an increase (p ≤ 0.05) in ROS levels and a decrease (p ≤ 0.05) in lipid content, while maintaining mitochondrial activity similar (p > 0.05) to that of the control group. Regarding gene expression, the effect of pre-IVM, independent of melatonin, was characterized by a decrease in FABP3 transcripts in cumulus cells and reductions in GSS and NFE2L2 transcripts in oocytes (p ≤ 0.05). The pre-IVM + MTn group also displayed a decrease (p ≤ 0.05) in CAT and SOD2 transcript levels. In terms of embryonic development, the pre-IVM + MTn group achieved a higher blastocyst rate on D7 (p ≤ 0.05) compared to the control group (30.8% versus 25.8%), but with similar rates (p > 0.05) to the pre-IVM control group (30.8% versus 35.9%). However, there was a decrease in the levels of the PLAC8 transcript. This study indicates that, under the conditions tested, melatonin did not significantly benefit oocyte competence. Full article
(This article belongs to the Section Natural and Synthetic Antioxidants)
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27 pages, 16782 KiB  
Article
Response of Grain Yield to Extreme Precipitation in Major Grain-Producing Areas of China Against the Background of Climate Change—A Case Study of Henan Province
by Keding Sheng, Rui Li, Fengqiuli Zhang, Tongde Chen, Peng Liu, Yanan Hu, Bingyin Li and Zhiyuan Song
Water 2025, 17(15), 2342; https://doi.org/10.3390/w17152342 - 6 Aug 2025
Abstract
Based on the panel data of daily meteorological stations and winter wheat yield in Henan Province from 2000 to 2023, this study comprehensively used the Mann–Kendall trend test, wavelet coherence analysis (WTC), and other methods to reveal the temporal and spatial evolution of [...] Read more.
Based on the panel data of daily meteorological stations and winter wheat yield in Henan Province from 2000 to 2023, this study comprehensively used the Mann–Kendall trend test, wavelet coherence analysis (WTC), and other methods to reveal the temporal and spatial evolution of extreme precipitation and its multi-scale stress mechanism on grain yield. The results showed the following: (1) Extreme precipitation showed the characteristics of ‘frequent fluctuation-gentle trend-strong spatial heterogeneity’, and the maximum daily precipitation in spring (RX1DAY) showed a significant uplift. The increase in rainstorm events (R95p/R99p) in the southern region during the summer is particularly prominent; at the same time, the number of consecutive drought days (CDDs > 15 d) in the middle of autumn was significantly prolonged. It was also found that 2010 is a significant mutation node. Since then, the synergistic effect of ‘increasing drought days–increasing rainstorm frequency’ has begun to appear, and the short-period coherence of super-strong precipitation (R99p) has risen to more than 0.8. (2) The spatial pattern of winter wheat in Henan is characterized by the three-level differentiation of ‘stable core area, sensitive transition zone and shrinking suburban area’, and the stability of winter wheat has improved but there are still local risks. (3) There is a multi-scale stress mechanism of extreme precipitation on winter wheat yield. The long-period (4–8 years) drought and flood events drive the system risk through a 1–2-year lag effect (short-period (0.5–2 years) medium rainstorm intensity directly impacted the production system). This study proposes a ‘sub-scale governance’ strategy, using a 1–2-year lag window to establish a rainstorm warning mechanism, and optimizing drainage facilities for high-risk areas of floods in the south to improve the climate resilience of the agricultural system against the background of climate change. Full article
(This article belongs to the Special Issue Soil Erosion and Soil and Water Conservation, 2nd Edition)
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20 pages, 5638 KiB  
Article
Influence of Heat Treatment on Precipitate and Microstructure of 38CrMoAl Steel
by Guofang Xu, Shiheng Liang, Bo Chen, Jiangtao Chen, Yabing Zhang, Xiaotan Zuo, Zihan Li, Bo Song and Wei Liu
Materials 2025, 18(15), 3703; https://doi.org/10.3390/ma18153703 - 6 Aug 2025
Abstract
To address the central cracking problem in continuous casting slabs of 38CrMoAl steel, high-temperature tensile tests were performed using a Gleeble-3800 thermal simulator to characterize the hot ductility of the steel within the temperature range of 600–1200 °C. The phase transformation behavior was [...] Read more.
To address the central cracking problem in continuous casting slabs of 38CrMoAl steel, high-temperature tensile tests were performed using a Gleeble-3800 thermal simulator to characterize the hot ductility of the steel within the temperature range of 600–1200 °C. The phase transformation behavior was computationally analyzed via the Thermo-Calc software, while the microstructure, fracture morphology, and precipitate characteristics were systematically investigated using a metallographic microscope (MM), a field-emission scanning electron microscope (FE-SEM), and transmission electron microscopy (TEM). Additionally, the effects of different holding times and cooling rates on the microstructure and precipitates of 38CrMoAl steel were also studied. The results show that the third brittle temperature region of 38CrMoAl steel is 645–1009 °C, and the fracture mechanisms can be classified into three types: (I) in the α single-phase region, the thickness of intergranular proeutectoid ferrite increases with rising temperature, leading to reduced hot ductility; (II) in the γ single-phase region, the average size of precipitates increases while the number density decreases with increasing temperature, thereby improving hot ductility; and (III) in the α + γ two-phase region, the precipitation of proeutectoid ferrite promotes crack propagation and the dense distribution of precipitates at grain boundaries causes stress concentration, further deteriorating hot ductility. Heat treatment experiments indicate that the microstructures of the specimen transformed under water cooling, air cooling, and furnace cooling conditions as follows: martensite + proeutectoid ferrite → bainite + ferrite → ferrite. The average size of precipitates first decreased, then increased, and finally decreased again with increasing holding time, while the number density exhibited the opposite trend. Therefore, when the holding time was the same, reducing the cooling rate could increase the average size of the precipitates and decrease their number density, thereby improving the hot ductility of 38CrMoAl steel. Full article
(This article belongs to the Special Issue Microstructure Engineering of Metals and Alloys, 3rd Edition)
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13 pages, 2040 KiB  
Article
Study on the Shear Characteristics of the Frozen Soil–Concrete Interface at Different Roughness Levels
by Ming Xie, Mengqi Xu, Fangbo Xu, Zhangdong Wang, Lie Yin and Xiangdong Wu
Buildings 2025, 15(15), 2783; https://doi.org/10.3390/buildings15152783 - 6 Aug 2025
Abstract
The shear characteristics of the frozen soil–concrete interface are core parameters in frost heave resistance design in cold-region engineering, and the influence mechanism of interface roughness on these characteristics is not clear. In this study, the regulatory effect of different roughness levels (R-0 [...] Read more.
The shear characteristics of the frozen soil–concrete interface are core parameters in frost heave resistance design in cold-region engineering, and the influence mechanism of interface roughness on these characteristics is not clear. In this study, the regulatory effect of different roughness levels (R-0 to R-4) on the interfacial freezing strength was quantitatively analyzed for the first time through direct shear tests, and the evolution characteristics of the contribution ratio of the ice cementation strength were revealed. The results show that the peak shear strength of the interface increases significantly with the roughness (when the normal stress is 400 kPa and the water content is 14%, the increase in R-4 is 47.7% compared with R-0); the ice cementation strength increases synchronously and its contribution ratio increases with the increase in roughness. Although the absolute value of the residual strength increase is small, the relative amplitude is larger (178.5% increase under the same working conditions). The peak cohesion increased significantly with the roughness (R-0 to R-4 increased by 268.6%), while the residual cohesion decreased. The peak and residual internal friction angle increased slightly with the roughness. The study clarifies the differential influence mechanism of roughness on the interface’s shear parameters and provides a key quantitative basis for the anti-frost heave design of engineering interfaces in cold regions. Full article
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23 pages, 12563 KiB  
Article
Optimization of Grouser–Track Structural Parameters for Enhanced Tractive Performance in Unmanned Amphibious Tracked Vehicles
by Yaoyao Chen, Xiaojun Xu, Wenhao Wang, Xue Gao and Congnan Yang
Actuators 2025, 14(8), 390; https://doi.org/10.3390/act14080390 - 6 Aug 2025
Abstract
This study focuses on optimizing track and grouser structural parameters to enhance UATV drawbar pull, particularly under soft soil conditions. A numerical soil thrust model for single-track shoes was developed based on track–soil interaction mechanics, revealing distinct mechanistic roles: track structural parameters (length/width) [...] Read more.
This study focuses on optimizing track and grouser structural parameters to enhance UATV drawbar pull, particularly under soft soil conditions. A numerical soil thrust model for single-track shoes was developed based on track–soil interaction mechanics, revealing distinct mechanistic roles: track structural parameters (length/width) govern pressure–sinkage relationships at the track base, while grouser structural parameters (height, spacing, V-shaped angle) dominate shear stress–displacement dynamics on grouser shear planes. A novel DEM-MBD coupling simulation framework was established through soil parameter calibration and multi-body dynamics modeling, demonstrating that soil thrust increases with grouser height and V-shaped angle, but decreases with spacing, with grouser height exhibiting the highest sensitivity. A soil bin test validated the numerical model’s accuracy and the coupling method’s efficacy. Parametric optimization via the Whale Optimization Algorithm (WOA) achieved a 55.86% increase in drawbar pull, 40.38% reduction in ground contact pressure and 57.33% improvement in maximum gradability. These advancements substantially improve the tractive performance of UATVs in soft beach terrains. The proposed methodology provides a systematic framework for amphibious vehicle design, integrating numerical modeling, high-fidelity simulation, and experimental validation. Full article
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27 pages, 28656 KiB  
Article
Experimental Study and FEM Analysis on the Strengthening of Masonry Brick Walls Using Expanded Steel Plates and Shotcrete with and Without Glass Fiber Reinforcement
by Zeynep Yaman, Alper Cumhur, Elif Ağcakoca, Muhammet Zeki Özyurt, Muhammed Maraşlı, Mohammad Saber Sadid, Abdulsalam Akrami and Azizullah Rasuly
Buildings 2025, 15(15), 2781; https://doi.org/10.3390/buildings15152781 - 6 Aug 2025
Abstract
In this study, an effective strengthening method was investigated to improve the seismic performance of masonry brick walls. The strengthening method comprised the use of shotcrete, which was applied in both glass fiber-reinforced and unreinforced forms for steel plates and tie rods. Thirteen [...] Read more.
In this study, an effective strengthening method was investigated to improve the seismic performance of masonry brick walls. The strengthening method comprised the use of shotcrete, which was applied in both glass fiber-reinforced and unreinforced forms for steel plates and tie rods. Thirteen wall specimens constructed with vertical perforated masonry block bricks were tested under diagonal compression in accordance with ASTM E519 (2010). Reinforcement plates with different thicknesses (1.5 mm, 2 mm, and 3 mm) were anchored using 6 mm diameter tie rods. A specially designed steel frame and an experimental loading program with controlled deformation increments were employed to simulate the effects of reinforced concrete beam frame system on walls under the effect of diagonal loads caused by seismic loads. In addition, numerical simulations were conducted using three-dimensional finite element models in Abaqus Explicit software to validate the experimental results. The findings demonstrated that increasing the number of tie rods enhanced the shear strength and overall behavior of the walls. Steel plates effectively absorbed tensile stresses and limited crack propagation, while the fiber reinforcement in the shotcrete further improved wall strength and ductility. Overall, the proposed strengthening techniques provided significant improvements in the seismic resistance and energy absorption capacity of masonry walls, offering practical and reliable solutions to enhance the safety and durability of existing masonry structures. Full article
(This article belongs to the Special Issue Advanced Research on Concrete Materials in Construction)
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25 pages, 6471 KiB  
Article
Rheological Evaluation of Ultra-High-Performance Concrete as a Rehabilitation Alternative for Pavement Overlays
by Hermes Vacca, Yezid A. Alvarado, Daniel M. Ruiz and Andres M. Nuñez
Materials 2025, 18(15), 3700; https://doi.org/10.3390/ma18153700 - 6 Aug 2025
Abstract
This study evaluates the rheological behavior and mechanical performance of Ultra-High-Performance Fiber-Reinforced Concrete (UHPFRC) mixes with varying superplasticizer dosages, aiming to optimize their use in pavement rehabilitation overlays on sloped surfaces. A reference self-compacting UHPFRC mix was modified by reducing the superplasticizer-to-binder ratio [...] Read more.
This study evaluates the rheological behavior and mechanical performance of Ultra-High-Performance Fiber-Reinforced Concrete (UHPFRC) mixes with varying superplasticizer dosages, aiming to optimize their use in pavement rehabilitation overlays on sloped surfaces. A reference self-compacting UHPFRC mix was modified by reducing the superplasticizer-to-binder ratio in incremental steps, and the resulting mixes were assessed through rheometry, mini-Slump, and Abrams cone tests. Key rheological parameters—static and dynamic yield stress, plastic viscosity, and thixotropy—were determined using the modified Bingham model. The results showed that reducing superplasticizer content increased yield stress and viscosity, enhancing thixotropic behavior while maintaining ultra-high compressive (≥130 MPa) and flexural strength (≥20 MPa) at 28 days. A predictive model was validated to estimate the critical yield stress needed for overlays on slopes. Among the evaluated formulations, the SP-2 mix met the stability and performance criteria and was successfully tested in a prototype overlay, demonstrating its viability for field application. This research confirms the potential of rheology-tailored UHPFRC as a high-performance solution for durable and stable pavement overlays in demanding geometric conditions. Full article
(This article belongs to the Special Issue Advances in Material Characterization and Pavement Modeling)
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14 pages, 4016 KiB  
Article
Failure Mechanism of Pre-Stressed CFRP Beam Under Laser Ablation
by Yuting Zhao, Ruokun Zhang and Zhuhua Tan
Polymers 2025, 17(15), 2153; https://doi.org/10.3390/polym17152153 - 6 Aug 2025
Abstract
This paper focuses on the failure mechanism of a pre-stressed CFRP cantilever beam under laser ablation. During testing, a mass was applied to the CFRP cantilever beam to achieve a pre-stressed state, and the laser power densities varied from 500 to 1500 W·cm [...] Read more.
This paper focuses on the failure mechanism of a pre-stressed CFRP cantilever beam under laser ablation. During testing, a mass was applied to the CFRP cantilever beam to achieve a pre-stressed state, and the laser power densities varied from 500 to 1500 W·cm−2. Corresponding scanning electron microscope (SEM) tests were also performed on the ablation zone and fracture surface to analyze the failure mechanism. The results showed that the CFRP beam failed in compression at the bottom surface, which was due to a decrease in local stiffness and strength caused by heat softening, rather than by ablation damage on the top surface. The failure time decreased from 19.64 s to 6.52 s as the power density (500–1500 W·cm−2) and pre-stress loading (300–750 N·cm) increased, indicating that pre-stress loading has a more significant influence on the failure time of CFRP beams compared to power density. Full article
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16 pages, 3450 KiB  
Article
Comparative In Vitro Analysis of Composite Resins Used in Clear Aligner Attachments
by Francesca Gazzani, Denise Bellisario, Chiara Pavoni, Loredana Santo, Paola Cozza and Roberta Lione
Appl. Sci. 2025, 15(15), 8698; https://doi.org/10.3390/app15158698 (registering DOI) - 6 Aug 2025
Abstract
Background: Attachments are essential components in clear aligner therapy, enhancing retention and improving the predictability of tooth movements. Mechanical and wear properties of the composite resins used for attachment reproduction are critical to maintaining their integrity and shape over time. This study aimed [...] Read more.
Background: Attachments are essential components in clear aligner therapy, enhancing retention and improving the predictability of tooth movements. Mechanical and wear properties of the composite resins used for attachment reproduction are critical to maintaining their integrity and shape over time. This study aimed to evaluate and compare the mechanical properties, thermal behavior, and wear performance of the hybrid composite Aligner Connect (AC) and the flowable resin (Connect Flow, CF). Methods: Twenty samples (ten AC and ten CF) were reproduced. All specimens underwent differential scanning calorimetry (DSC), combustion analysis, flat instrumented indentation, compression stress relaxation tests, and tribological analysis. A 3D wear profile reconstruction was performed to assess wear surfaces. Results: DSC and combustion analyses revealed distinct thermal transitions, with CF showing significantly lower Tg values (103.8 °C/81.4 °C) than AC (110.8 °C/89.6 °C) and lower residual mass after combustion (23% vs. 61%), reflecting reduced filler content and greater polymer mobility. AC exhibited superior mechanical properties, with higher maximum load (585.9 ± 22.36 N) and elastic modulus (231.5 ± 9.1 MPa) than CF (290.2 ± 5.52 N; 156 ± 10.5 MPa). Stress relaxation decrease was less pronounced in AC (18 ± 4%) than in CF (20 ± 4%). AC also showed a significantly higher friction coefficient (0.62 ± 0.060) than CF (0.55 ± 0.095), along with greater wear volume (0.012 ± 0.0055 mm3 vs. 0.0070 ± 0.0083 mm3) and maximum depth (36.88 ± 3.642 µm vs. 17.91 ± 3.387 µm). Surface roughness before wear was higher for AC (Ra, 0.577 ± 0.035 µm; Rt, 4.369 ± 0.521 µm) than for CF (Ra, 0.337 ± 0.070 µm; Rt, 2.862 ± 0.549 µm). After wear tests, roughness values converged (Ra, 0.247 ± 0.036 µm for AC; Ra, 0.236 ± 0.019 µm for CF) indicating smoothened and similar surfaces for both composites. Conclusions: The hybrid nanocomposite demonstrated greater properties in terms of stiffness, load-bearing capacity, and structural integrity when compared with flowable resin. Its use may ensure more durable attachment integrity and improved aligner–tooth interface performance over time. Full article
(This article belongs to the Special Issue Innovative Materials and Technologies in Orthodontics)
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22 pages, 25395 KiB  
Article
Hot Deformation and Predictive Modelling of β-Ti-15Mo Alloy: Linking Flow Stress, ω-Phase Evolution, and Thermomechanical Behaviour
by Arthur de Bribean Guerra, Alberto Moreira Jorge Junior, Guilherme Yuuki Koga and Claudemiro Bolfarini
Metals 2025, 15(8), 877; https://doi.org/10.3390/met15080877 (registering DOI) - 6 Aug 2025
Abstract
This study investigates the hot deformation behaviour and flow stress prediction of metastable β-Ti-15Mo alloy, a promising material for biomedical applications requiring strength–modulus optimisation and thermomechanical tunability. Isothermal compression tests were performed within the temperature range of 923–1173 K and at strain rates [...] Read more.
This study investigates the hot deformation behaviour and flow stress prediction of metastable β-Ti-15Mo alloy, a promising material for biomedical applications requiring strength–modulus optimisation and thermomechanical tunability. Isothermal compression tests were performed within the temperature range of 923–1173 K and at strain rates of 0.17, 1.72, and 17.2 s1 to assess the material’s response under industrially relevant hot working conditions. The alloy showed significant sensitivity to temperature and strain rate, with dynamic recovery (DRV) and dynamic recrystallisation (DRX) dominating the softening behaviour depending on the conditions. A strain-compensated Arrhenius-type constitutive model was developed and validated, resulting in an apparent activation energy of approximately 234 kJ/mol. Zener–Hollomon parameter analysis confirmed a transition in deformation mechanisms. Although microstructural and diffraction data suggest possible contributions from nanoscale phase transformations, including ω-phase dissolution at high temperatures, these aspects remain to be fully elucidated. The model offers reliable predictions of flow behaviour and supports optimisation of thermomechanical processing routes for biomedical β-Ti alloys. Full article
(This article belongs to the Special Issue Hot Forming/Processing of Metals and Alloys)
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18 pages, 3229 KiB  
Article
AMPK-Targeting Effects of (−)-Epicatechin Gallate from Hibiscus sabdariffa Linne Leaves on Dual Modulation of Hepatic Lipid Accumulation and Glycogen Synthesis in an In Vitro Oleic Acid Model
by Hui-Hsuan Lin, Pei-Tzu Wu, Yu-Hsuan Liang, Ming-Shih Lee and Jing-Hsien Chen
Int. J. Mol. Sci. 2025, 26(15), 7612; https://doi.org/10.3390/ijms26157612 - 6 Aug 2025
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) begins with hepatic lipid accumulation and triggers insulin resistance. Hibiscus leaf extract exhibits antioxidant and anti-atherosclerotic activities, and is rich in (−)-epicatechin gallate (ECG). Despite ECG’s well-known pharmacological activities and its total antioxidant capacity being stronger than [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) begins with hepatic lipid accumulation and triggers insulin resistance. Hibiscus leaf extract exhibits antioxidant and anti-atherosclerotic activities, and is rich in (−)-epicatechin gallate (ECG). Despite ECG’s well-known pharmacological activities and its total antioxidant capacity being stronger than that of other catechins, its regulatory effects on MASLD have not been fully described previously. Therefore, this study attempted to evaluate the anti-MASLD potential of ECG isolated from Hibiscus leaves on abnormal lipid and glucose metabolism in hepatocytes. First, oleic acid (OA) was used as an experimental model to induce lipid dysmetabolism in human primary hepatocytes. Treatment with ECG can significantly (p < 0.05) reduce the OA-induced cellular lipid accumulation. Nile red staining revealed, compared to the OA group, the inhibition percentages of 29, 61, and 82% at the tested doses of ECG, respectively. The beneficial effects of ECG were associated with the downregulation of SREBPs/HMGCR and upregulation of PPARα/CPT1 through targeting AMPK. Also, ECG at 0.4 µM produced a significant (p < 0.01) decrease in oxidative stress by 83%, and a marked (p < 0.05) increase in glycogen synthesis by 145% on the OA-exposed hepatocytes with insulin signaling blockade. Mechanistic assays indicated lipid and glucose metabolic homeostasis of ECG might be mediated via regulation of lipogenesis, fatty acid β-oxidation, and insulin resistance, as confirmed by an AMPK inhibitor. These results suggest ECG is a dual modulator of lipid and carbohydrate dysmetabolism in hepatocytes. Full article
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33 pages, 891 KiB  
Article
Effectiveness of a Mind–Body Intervention at Improving Mental Health and Performance Among Career Firefighters
by Anthony C. Santos, Seth Long, Christopher P. Moreno and Dierdra Bycura
Int. J. Environ. Res. Public Health 2025, 22(8), 1227; https://doi.org/10.3390/ijerph22081227 - 6 Aug 2025
Abstract
Almost one in three firefighters develop mental health disorders at some point during their careers, a rate double that in the general population. Frequent exposures to potentially traumatic situations can contribute to symptoms of these disorders, two of the most common being depression [...] Read more.
Almost one in three firefighters develop mental health disorders at some point during their careers, a rate double that in the general population. Frequent exposures to potentially traumatic situations can contribute to symptoms of these disorders, two of the most common being depression and post-traumatic stress disorder (PTSD). While various psychological interventions have been implemented among this group, reports of their effectiveness include mixed results. To this end, the current study endeavored to test the effectiveness of a 12-week intervention combining occupationally-tailored high-intensity functional training (HIFT) and psychological resilience training (RES) in reducing depressive and post-traumatic stress symptoms (PTSSs), as well as increasing psychological resilience and mental wellbeing, in career firefighters. Thirty career firefighters completed four mental health measurements over 17 weeks while anthropometrics and physical performance (i.e., number of stations completed in 20 min during an eight-station simulated job-task circuit workout [T-CAC]) were measured pre- and post-intervention. Pre to post comparisons were made via repeated-measures t-tests. Significant mean differences were observed for T-CAC stations completed, PTSSs, and psychological resilience between pre- and post-intervention. In future interventions, researchers should actively engage firefighters, maximize integration with daily operations, and employ culturally-relevant practices to explore the links between physical and mental health. Full article
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22 pages, 9502 KiB  
Article
Phase-Field Modeling of Thermal Fracturing Mechanisms in Reservoir Rock Under High-Temperature Conditions
by Guo Tang, Dianbin Guo, Wei Zhong, Li Du, Xiang Mao and Man Li
Appl. Sci. 2025, 15(15), 8693; https://doi.org/10.3390/app15158693 (registering DOI) - 6 Aug 2025
Abstract
Thermal stimulation represents an effective method for enhancing reservoir permeability, thereby improving geothermal energy recovery in Enhanced Geothermal Systems (EGS). The phase-field method (PFM) has been widely adopted for its proven capability in modeling the fracture behavior of brittle solids. Consequently, a coupled [...] Read more.
Thermal stimulation represents an effective method for enhancing reservoir permeability, thereby improving geothermal energy recovery in Enhanced Geothermal Systems (EGS). The phase-field method (PFM) has been widely adopted for its proven capability in modeling the fracture behavior of brittle solids. Consequently, a coupled thermo-mechanical phase-field model (TM-PFM) was developed in COMSOL 6.2 Multiphysics to probe thermal fracturing mechanisms in reservoir rocks. The TM-PFM was validated against the analytical solutions for the temperature and stress fields under steady-state heat conduction in a thin-walled cylinder, three-point bending tests, and thermal shock tests. Subsequently, two distinct thermal fracturing modes in reservoir rock under high-temperature conditions were investigated: (i) fracture initiation driven by sharp temperature gradients during instantaneous thermal shocks, and (ii) crack propagation resulting from heterogeneous thermal expansion of constituent minerals. The proposed TM-PFM has been validated through systematic comparison between the simulation results and the corresponding experimental data, thereby demonstrating its capability to accurately simulate thermal fracturing. These findings provide mechanistic insights for optimizing geothermal energy extraction in EGS. Full article
(This article belongs to the Special Issue Advances in Failure Mechanism and Numerical Methods for Geomaterials)
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16 pages, 2440 KiB  
Article
Dog–Stranger Interactions Can Facilitate Canine Incursion into Wilderness: The Role of Food Provisioning and Sociability
by Natalia Rojas-Troncoso, Valeria Gómez-Silva, Annegret Grimm-Seyfarth and Elke Schüttler
Biology 2025, 14(8), 1006; https://doi.org/10.3390/biology14081006 - 6 Aug 2025
Abstract
Most research on domestic dog (Canis familiaris) behavior has focused on pets with restricted movement. However, free-ranging dogs exist in diverse cultural contexts globally, and their interactions with humans are less understood. Tourists can facilitate unrestricted dog movement into wilderness areas, [...] Read more.
Most research on domestic dog (Canis familiaris) behavior has focused on pets with restricted movement. However, free-ranging dogs exist in diverse cultural contexts globally, and their interactions with humans are less understood. Tourists can facilitate unrestricted dog movement into wilderness areas, where they may negatively impact wildlife. This study investigated which stimuli—namely, voice, touch, or food—along with inherent factors (age, sex, sociability) motivate free-ranging dogs to follow a human stranger. We measured the distance (up to 600 m) of 129 free-ranging owned and stray dogs from three villages in southern Chile as they followed an experimenter who presented them one of the above stimuli or none (control). To evaluate the effect of dog sociability (i.e., positive versus stress-related or passive behaviors), we performed a 30 s socialization test (standing near the dog without interacting) before presenting a 10 s stimulus twice. We also tracked whether the dog was in the company of other dogs. Each focus dog was video-recorded and tested up to three times over five days. Generalized linear mixed-effects models revealed that the food stimulus significantly influenced dogs’ motivation to follow a stranger, as well as a high proportion of sociable behaviors directed towards humans and the company of other dogs present during the experiment. Juveniles tended to follow a stranger more than adults or seniors, but no effects were found for the dog’s sex, whether an owner was present, the repetition of trials, the location where the study was performed, or for individuals as a random variable. This research highlights that sociability as an inherent factor shapes dog–stranger interactions in free-ranging dogs when food is given. In the context of wildlife conservation, we recommend that managers promote awareness among local communities and tourists to avoid feeding dogs, especially in the context of outdoor activities close to wilderness. Full article
(This article belongs to the Special Issue Biology, Ecology, Management and Conservation of Canidae)
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