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Article

6 Citations

2,916 Views

18 Pages

Synthesis of Sterically Shielded Nitroxides Using the Reaction of Nitrones with Alkynylmagnesium Bromides

Sergey A. Dobrynin,
Mark M. Gulman,
Denis A. Morozov,
Irina F. Zhurko,
Andrey I. Taratayko,
Yulia S. Sotnikova,
Yurii I. Glazachev,
Yuri V. Gatilov and
Igor A. Kirilyuk

Molecules2022, 27(21), 7626;https://doi.org/10.3390/molecules27217626

7 November 2022

Sterically shielded nitroxides, which demonstrate high resistance to bioreduction, are the spin labels of choice for structural studies inside living cells using pulsed EPR and functional MRI and EPRI in vivo. To prepare new sterically shielded nitro...

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Article

3 Citations

2,003 Views

24 Pages

Synthesis and Properties of (1R(S),5R(S),7R(S),8R(S))-1,8-Bis(hydroxymethyl)-6-azadispiro[4.1.4.2]tridecane-6-oxyl: Reduction-Resistant Spin Labels with High Spin Relaxation Times

Yulia V. Khoroshunova,
Denis A. Morozov,
Danil A. Kuznetsov,
Tatyana V. Rybalova,
Yurii I. Glazachev,
Elena G. Bagryanskaya and
Igor A. Kirilyuk

Int. J. Mol. Sci.2023, 24(14), 11498;https://doi.org/10.3390/ijms241411498

15 July 2023

Site-directed spin labeling followed by investigation using Electron Paramagnetic Resonance spectroscopy is a rapidly expanding powerful biophysical technique to study structure, local dynamics and functions of biomolecules using pulsed EPR technique...

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Article

17 Citations

3,867 Views

18 Pages

A Simple Method of Synthesis of 3-Carboxy-2,2,5,5-Tetraethylpyrrolidine-1-oxyl and Preparation of Reduction-Resistant Spin Labels and Probes of Pyrrolidine Series

Sergey A. Dobrynin,
Mikhail S. Usatov,
Irina F. Zhurko,
Denis A. Morozov,
Yuliya F. Polienko,
Yurii I. Glazachev,
Dmitriy A. Parkhomenko,
Mikhail A. Tyumentsev,
Yuri V. Gatilov and
Igor A. Kirilyuk
+ 2 authors

Molecules2021, 26(19), 5761;https://doi.org/10.3390/molecules26195761

23 September 2021

Stable free radicals are widely used as molecular probes and labels in various biophysical and biomedical research applications of magnetic resonance spectroscopy and imaging. Among these radicals, sterically shielded nitroxides of pyrrolidine series...

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Review

62 Citations

13,662 Views

28 Pages

New Developments in Spin Labels for Pulsed Dipolar EPR

Alistair J. Fielding,
Maria Grazia Concilio,
Graham Heaven and
Michael A. Hollas

Molecules2014, 19(10), 16998-17025;https://doi.org/10.3390/molecules191016998

23 October 2014

Spin labelling is a chemical technique that enables the integration of a molecule containing an unpaired electron into another framework for study. Given the need to understand the structure, dynamics, and conformational changes of biomacromolecules,...

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Article

38 Citations

7,283 Views

13 Pages

Stability of ZIF-8 Nanoparticles in Most Common Cell Culture Media

Anna S. Spitsyna,
Artem S. Poryvaev,
Natalya E. Sannikova,
Anastasiya A. Yazikova,
Igor A. Kirilyuk,
Sergey A. Dobrynin,
Olga A. Chinak,
Matvey V. Fedin and
Olesya A. Krumkacheva

Molecules2022, 27(10), 3240;https://doi.org/10.3390/molecules27103240

18 May 2022

Zeolite imidazolate framework-8 (ZIF-8) is a promising platform for drug delivery, and information regarding the stability of ZIF-8 nanoparticles in cell culture media is essential for proper interpretation of in vitro experimental results. In this w...

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